Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations.
Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blo...
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ftdoajarticles:oai:doaj.org/article:80c746b9610148808d6daa9846c74872 2023-05-15T15:08:34+02:00 Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. Annabelle de St Maurice Jessica Harmon Luke Nyakarahuka Stephen Balinandi Alex Tumusiime Jackson Kyondo Sophia Mulei Annemarion Namutebi Barbara Knust Trevor Shoemaker Stuart T Nichol Anita K McElroy Christina F Spiropoulou 2018-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006460 https://doaj.org/article/80c746b9610148808d6daa9846c74872 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5955566?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006460 https://doaj.org/article/80c746b9610148808d6daa9846c74872 PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006460 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006460 2022-12-31T08:57:13Z Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the affected patient. Severely affected patients can present with hemorrhagic manifestations of disease. In this study we identified three Ugandan men with RVFV disease that was accompanied by hemorrhagic manifestations. Serial blood samples from these men were analyzed for a series of biomarkers specific for various aspects of human pathophysiology including inflammation, endothelial function and coagulopathy. There were significant differences between biomarker levels in controls and cases both early during the illness and after clearance of viremia. Positive correlation of viral load with markers of inflammation (IP-10, CRP, Eotaxin, MCP-2 and Granzyme B), markers of fibrinolysis (tPA and D-dimer), and markers of endothelial function (sICAM-1) were all noted. However, and perhaps most interesting given the fact that these individuals exhibited hemorrhagic manifestations of disease, was the finding of a negative correlation between viral load and P-selectin, ADAMTS13, and fibrinogen all of which are associated with coagulation pathways occurring on the endothelial surface. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 5 e0006460 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Annabelle de St Maurice Jessica Harmon Luke Nyakarahuka Stephen Balinandi Alex Tumusiime Jackson Kyondo Sophia Mulei Annemarion Namutebi Barbara Knust Trevor Shoemaker Stuart T Nichol Anita K McElroy Christina F Spiropoulou Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Rift Valley fever virus is an arbovirus that affects both livestock and humans throughout Africa and in the Middle East. Despite its endemicity throughout Africa, it is a rare event to identify an infected individual during the acute phase of the disease and an even rarer event to collect serial blood samples from the affected patient. Severely affected patients can present with hemorrhagic manifestations of disease. In this study we identified three Ugandan men with RVFV disease that was accompanied by hemorrhagic manifestations. Serial blood samples from these men were analyzed for a series of biomarkers specific for various aspects of human pathophysiology including inflammation, endothelial function and coagulopathy. There were significant differences between biomarker levels in controls and cases both early during the illness and after clearance of viremia. Positive correlation of viral load with markers of inflammation (IP-10, CRP, Eotaxin, MCP-2 and Granzyme B), markers of fibrinolysis (tPA and D-dimer), and markers of endothelial function (sICAM-1) were all noted. However, and perhaps most interesting given the fact that these individuals exhibited hemorrhagic manifestations of disease, was the finding of a negative correlation between viral load and P-selectin, ADAMTS13, and fibrinogen all of which are associated with coagulation pathways occurring on the endothelial surface. |
format |
Article in Journal/Newspaper |
author |
Annabelle de St Maurice Jessica Harmon Luke Nyakarahuka Stephen Balinandi Alex Tumusiime Jackson Kyondo Sophia Mulei Annemarion Namutebi Barbara Knust Trevor Shoemaker Stuart T Nichol Anita K McElroy Christina F Spiropoulou |
author_facet |
Annabelle de St Maurice Jessica Harmon Luke Nyakarahuka Stephen Balinandi Alex Tumusiime Jackson Kyondo Sophia Mulei Annemarion Namutebi Barbara Knust Trevor Shoemaker Stuart T Nichol Anita K McElroy Christina F Spiropoulou |
author_sort |
Annabelle de St Maurice |
title |
Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. |
title_short |
Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. |
title_full |
Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. |
title_fullStr |
Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. |
title_full_unstemmed |
Rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. |
title_sort |
rift valley fever viral load correlates with the human inflammatory response and coagulation pathway abnormalities in humans with hemorrhagic manifestations. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006460 https://doaj.org/article/80c746b9610148808d6daa9846c74872 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 5, p e0006460 (2018) |
op_relation |
http://europepmc.org/articles/PMC5955566?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006460 https://doaj.org/article/80c746b9610148808d6daa9846c74872 |
op_doi |
https://doi.org/10.1371/journal.pntd.0006460 |
container_title |
PLOS Neglected Tropical Diseases |
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12 |
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5 |
container_start_page |
e0006460 |
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