Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites
Abstract Background Human populations exposed to low malaria transmission present particular severe risks of malaria morbidity and mortality. In addition, in a context of low-level exposure to Anopheles vector, conventional entomological methods used for sampling Anopheles populations are insufficie...
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Online Access: | https://doi.org/10.1186/1475-2875-8-198 https://doaj.org/article/80a6e49c7a3d4572b1b3b9a4cf0e89e9 |
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ftdoajarticles:oai:doaj.org/article:80a6e49c7a3d4572b1b3b9a4cf0e89e9 2023-05-15T15:17:31+02:00 Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites Simondon François Cisse Badara Sokhna Cheikh Rossignol Marie Boulanger Denis Sow Cheikh Ba Fatou Cornelie Sylvie Poinsignon Anne Remoue Franck 2009-08-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-198 https://doaj.org/article/80a6e49c7a3d4572b1b3b9a4cf0e89e9 EN eng BMC http://www.malariajournal.com/content/8/1/198 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-198 1475-2875 https://doaj.org/article/80a6e49c7a3d4572b1b3b9a4cf0e89e9 Malaria Journal, Vol 8, Iss 1, p 198 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-198 2022-12-31T08:43:55Z Abstract Background Human populations exposed to low malaria transmission present particular severe risks of malaria morbidity and mortality. In addition, in a context of low-level exposure to Anopheles vector, conventional entomological methods used for sampling Anopheles populations are insufficiently sensitive and probably under-estimate the real risk of malaria transmission. The evaluation of antibody (Ab) responses to arthropod salivary proteins constitutes a novel tool for estimating exposure level to insect bites. In the case of malaria, a recent study has shown that human IgG responses to the gSG6-P1 peptide represented a specific biomarker of exposure to Anopheles gambiae bites. The objective of this study was to investigate if this biomarker can be used to estimate low-level exposure of individuals to Anopheles vector. Methods The IgG Ab level to gSG6-P1 was evaluated at the peak and at the end of the An. gambiae exposure season in children living in Senegalese villages, where the Anophele s density was estimated to be very low by classical entomological trapping but where malaria transmission occurred during the studied season. Results Specific IgG responses to gSG6-P1 were observed in children exposed to very low-level of Anopheles bites. In addition, a significant increase in the specific IgG Ab level was observed during the Anopheles exposure season whereas classical entomological data have reported very few or no Anopheles during the studied period. Furthermore, this biomarker may also be applicable to evaluate the heterogeneity of individual exposure. Conclusion The results strengthen the hypothesis that the evaluation of IgG responses to gSG6-P1 during the season of exposure could reflect the real human contact with anthropophilic Anopheles and suggest that this biomarker of low exposure could be used at the individual level. This promising immuno-epidemiological marker could represent a useful tool to assess the risk to very low exposure to malaria vectors as observed in seasonal, urban, ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Simondon François Cisse Badara Sokhna Cheikh Rossignol Marie Boulanger Denis Sow Cheikh Ba Fatou Cornelie Sylvie Poinsignon Anne Remoue Franck Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Human populations exposed to low malaria transmission present particular severe risks of malaria morbidity and mortality. In addition, in a context of low-level exposure to Anopheles vector, conventional entomological methods used for sampling Anopheles populations are insufficiently sensitive and probably under-estimate the real risk of malaria transmission. The evaluation of antibody (Ab) responses to arthropod salivary proteins constitutes a novel tool for estimating exposure level to insect bites. In the case of malaria, a recent study has shown that human IgG responses to the gSG6-P1 peptide represented a specific biomarker of exposure to Anopheles gambiae bites. The objective of this study was to investigate if this biomarker can be used to estimate low-level exposure of individuals to Anopheles vector. Methods The IgG Ab level to gSG6-P1 was evaluated at the peak and at the end of the An. gambiae exposure season in children living in Senegalese villages, where the Anophele s density was estimated to be very low by classical entomological trapping but where malaria transmission occurred during the studied season. Results Specific IgG responses to gSG6-P1 were observed in children exposed to very low-level of Anopheles bites. In addition, a significant increase in the specific IgG Ab level was observed during the Anopheles exposure season whereas classical entomological data have reported very few or no Anopheles during the studied period. Furthermore, this biomarker may also be applicable to evaluate the heterogeneity of individual exposure. Conclusion The results strengthen the hypothesis that the evaluation of IgG responses to gSG6-P1 during the season of exposure could reflect the real human contact with anthropophilic Anopheles and suggest that this biomarker of low exposure could be used at the individual level. This promising immuno-epidemiological marker could represent a useful tool to assess the risk to very low exposure to malaria vectors as observed in seasonal, urban, ... |
format |
Article in Journal/Newspaper |
author |
Simondon François Cisse Badara Sokhna Cheikh Rossignol Marie Boulanger Denis Sow Cheikh Ba Fatou Cornelie Sylvie Poinsignon Anne Remoue Franck |
author_facet |
Simondon François Cisse Badara Sokhna Cheikh Rossignol Marie Boulanger Denis Sow Cheikh Ba Fatou Cornelie Sylvie Poinsignon Anne Remoue Franck |
author_sort |
Simondon François |
title |
Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites |
title_short |
Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites |
title_full |
Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites |
title_fullStr |
Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites |
title_full_unstemmed |
Human IgG response to a salivary peptide, gSG6-P1, as a new immuno-epidemiological tool for evaluating low-level exposure to Anopheles bites |
title_sort |
human igg response to a salivary peptide, gsg6-p1, as a new immuno-epidemiological tool for evaluating low-level exposure to anopheles bites |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-198 https://doaj.org/article/80a6e49c7a3d4572b1b3b9a4cf0e89e9 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 198 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/198 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-198 1475-2875 https://doaj.org/article/80a6e49c7a3d4572b1b3b9a4cf0e89e9 |
op_doi |
https://doi.org/10.1186/1475-2875-8-198 |
container_title |
Malaria Journal |
container_volume |
8 |
container_issue |
1 |
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1766347752191557632 |