Characteristics of Clostridium difficile infection in a high complexity hospital and report of the circulation of the NAP1/027 hypervirulent strain in Colombia
Introduction: Clostridium difficile is the main pathogen related to healthcare-associated diarrhea and it is the cause of 20 to 30% of diarrhea cases caused by antibiotics. In Colombia and Latin America, the knowledge about the epidemiological behavior of this infection is limited. Objective: To des...
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ftdoajarticles:oai:doaj.org/article:807ef538d16a4531b18558e80e241693 2023-05-15T15:11:57+02:00 Characteristics of Clostridium difficile infection in a high complexity hospital and report of the circulation of the NAP1/027 hypervirulent strain in Colombia Sandra Milena Gualtero Lina Alejandra Abril Nathalia Camelo Susi Daniela Sanchez Fabián Antonio Davila Gerson Arias Edwin Silva Ingrid Gissel Bustos Diego Fernando Josa Isabel Cristina Torres Luis Carlos Zambrano María José Pareja 2017-12-01T00:00:00Z https://doi.org/10.7705/biomedica.v37i4.3244 https://doaj.org/article/807ef538d16a4531b18558e80e241693 EN ES eng spa Instituto Nacional de Salud https://www.revistabiomedica.org/index.php/biomedica/article/view/3244 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v37i4.3244 https://doaj.org/article/807ef538d16a4531b18558e80e241693 Biomédica: revista del Instituto Nacional de Salud, Vol 37, Iss 4, Pp 466-472 (2017) Clostridium difficile bacterial infections anti-infective agents diarrhea enterocolitis pseudomembranous polymerase chain reaction Medicine R Arctic medicine. Tropical medicine RC955-962 article 2017 ftdoajarticles https://doi.org/10.7705/biomedica.v37i4.3244 2022-12-31T02:08:52Z Introduction: Clostridium difficile is the main pathogen related to healthcare-associated diarrhea and it is the cause of 20 to 30% of diarrhea cases caused by antibiotics. In Colombia and Latin America, the knowledge about the epidemiological behavior of this infection is limited. Objective: To describe the characteristics of a series of patients with C. difficile infection. Materials and methods: We performed a descriptive case series study of patients with C. difficile infection hospitalized in the Fundación Clínica Shaio from January, 2012, to November, 2015. Results: We analyzed 36 patients. The average age was 65 years. The risk factors associated with the infection were: previous use of antibiotics (94.4%), prior hospitalization in the last three months (66.7%) and use of proton pump inhibitors (50%). The most common comorbidities were chronic kidney disease (41.7%) and diabetes mellitus (30.6%). The most frequent symptoms were more than three loose stools per day (97.1%) and abdominal pain (42.9%). According to the severity of the disease, 44.4% of cases were classified as mild to moderate, 38.9% as severe, and 11.1% as complicated or severe. The detection of the toxin by PCR (GeneXpert) was the most common diagnostic procedure (63.8%). Global mortality during hospitalization was 8%. We identified four strains with serotype NAP1/027 and nine samples positive for binary toxin. Conclusion: Clostridium difficile infection should be suspected in patients with diarrhea and traditional risk factors associated with this disease. We report the circulation of the hypervirulent strain serotype NAP1/027 in Colombia, which should be countered with epidemiological surveillance and a prompt diagnosis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 37 4 466 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English Spanish |
topic |
Clostridium difficile bacterial infections anti-infective agents diarrhea enterocolitis pseudomembranous polymerase chain reaction Medicine R Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Clostridium difficile bacterial infections anti-infective agents diarrhea enterocolitis pseudomembranous polymerase chain reaction Medicine R Arctic medicine. Tropical medicine RC955-962 Sandra Milena Gualtero Lina Alejandra Abril Nathalia Camelo Susi Daniela Sanchez Fabián Antonio Davila Gerson Arias Edwin Silva Ingrid Gissel Bustos Diego Fernando Josa Isabel Cristina Torres Luis Carlos Zambrano María José Pareja Characteristics of Clostridium difficile infection in a high complexity hospital and report of the circulation of the NAP1/027 hypervirulent strain in Colombia |
topic_facet |
Clostridium difficile bacterial infections anti-infective agents diarrhea enterocolitis pseudomembranous polymerase chain reaction Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction: Clostridium difficile is the main pathogen related to healthcare-associated diarrhea and it is the cause of 20 to 30% of diarrhea cases caused by antibiotics. In Colombia and Latin America, the knowledge about the epidemiological behavior of this infection is limited. Objective: To describe the characteristics of a series of patients with C. difficile infection. Materials and methods: We performed a descriptive case series study of patients with C. difficile infection hospitalized in the Fundación Clínica Shaio from January, 2012, to November, 2015. Results: We analyzed 36 patients. The average age was 65 years. The risk factors associated with the infection were: previous use of antibiotics (94.4%), prior hospitalization in the last three months (66.7%) and use of proton pump inhibitors (50%). The most common comorbidities were chronic kidney disease (41.7%) and diabetes mellitus (30.6%). The most frequent symptoms were more than three loose stools per day (97.1%) and abdominal pain (42.9%). According to the severity of the disease, 44.4% of cases were classified as mild to moderate, 38.9% as severe, and 11.1% as complicated or severe. The detection of the toxin by PCR (GeneXpert) was the most common diagnostic procedure (63.8%). Global mortality during hospitalization was 8%. We identified four strains with serotype NAP1/027 and nine samples positive for binary toxin. Conclusion: Clostridium difficile infection should be suspected in patients with diarrhea and traditional risk factors associated with this disease. We report the circulation of the hypervirulent strain serotype NAP1/027 in Colombia, which should be countered with epidemiological surveillance and a prompt diagnosis. |
format |
Article in Journal/Newspaper |
author |
Sandra Milena Gualtero Lina Alejandra Abril Nathalia Camelo Susi Daniela Sanchez Fabián Antonio Davila Gerson Arias Edwin Silva Ingrid Gissel Bustos Diego Fernando Josa Isabel Cristina Torres Luis Carlos Zambrano María José Pareja |
author_facet |
Sandra Milena Gualtero Lina Alejandra Abril Nathalia Camelo Susi Daniela Sanchez Fabián Antonio Davila Gerson Arias Edwin Silva Ingrid Gissel Bustos Diego Fernando Josa Isabel Cristina Torres Luis Carlos Zambrano María José Pareja |
author_sort |
Sandra Milena Gualtero |
title |
Characteristics of Clostridium difficile infection in a high complexity hospital and report of the circulation of the NAP1/027 hypervirulent strain in Colombia |
title_short |
Characteristics of Clostridium difficile infection in a high complexity hospital and report of the circulation of the NAP1/027 hypervirulent strain in Colombia |
title_full |
Characteristics of Clostridium difficile infection in a high complexity hospital and report of the circulation of the NAP1/027 hypervirulent strain in Colombia |
title_fullStr |
Characteristics of Clostridium difficile infection in a high complexity hospital and report of the circulation of the NAP1/027 hypervirulent strain in Colombia |
title_full_unstemmed |
Characteristics of Clostridium difficile infection in a high complexity hospital and report of the circulation of the NAP1/027 hypervirulent strain in Colombia |
title_sort |
characteristics of clostridium difficile infection in a high complexity hospital and report of the circulation of the nap1/027 hypervirulent strain in colombia |
publisher |
Instituto Nacional de Salud |
publishDate |
2017 |
url |
https://doi.org/10.7705/biomedica.v37i4.3244 https://doaj.org/article/807ef538d16a4531b18558e80e241693 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 37, Iss 4, Pp 466-472 (2017) |
op_relation |
https://www.revistabiomedica.org/index.php/biomedica/article/view/3244 https://doaj.org/toc/0120-4157 0120-4157 doi:10.7705/biomedica.v37i4.3244 https://doaj.org/article/807ef538d16a4531b18558e80e241693 |
op_doi |
https://doi.org/10.7705/biomedica.v37i4.3244 |
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Biomédica |
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37 |
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4 |
container_start_page |
466 |
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1766342718147002368 |