Nanoemulsion and Nanogel Containing Cuminum cyminum L Essential Oil: Antioxidant, Anticancer, Antibacterial, and Antilarval Properties
Cuminum cyminum L. is a widespread medicinal plant with a broad spectrum of biological activity. In the present study, the chemical structure of its essential oil was examined utilizing GC-MS analysis (gas chromatography-mass spectrometry). Then, a nanoemulsion dosage form was prepared with a drople...
Published in: | Journal of Tropical Medicine |
---|---|
Main Authors: | , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Hindawi Limited
2023
|
Subjects: | |
Online Access: | https://doi.org/10.1155/2023/5075581 https://doaj.org/article/80555e6df630435e977a030ba6ca67e2 |
id |
ftdoajarticles:oai:doaj.org/article:80555e6df630435e977a030ba6ca67e2 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:80555e6df630435e977a030ba6ca67e2 2023-05-15T15:08:05+02:00 Nanoemulsion and Nanogel Containing Cuminum cyminum L Essential Oil: Antioxidant, Anticancer, Antibacterial, and Antilarval Properties Razie Ranjbar Elham Zarenezhad Abbas Abdollahi Marjan Nasrizadeh Samira Firooziyan Najmeh Namdar Mahmoud Osanloo 2023-01-01T00:00:00Z https://doi.org/10.1155/2023/5075581 https://doaj.org/article/80555e6df630435e977a030ba6ca67e2 EN eng Hindawi Limited http://dx.doi.org/10.1155/2023/5075581 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2023/5075581 https://doaj.org/article/80555e6df630435e977a030ba6ca67e2 Journal of Tropical Medicine, Vol 2023 (2023) Arctic medicine. Tropical medicine RC955-962 article 2023 ftdoajarticles https://doi.org/10.1155/2023/5075581 2023-02-26T01:41:25Z Cuminum cyminum L. is a widespread medicinal plant with a broad spectrum of biological activity. In the present study, the chemical structure of its essential oil was examined utilizing GC-MS analysis (gas chromatography-mass spectrometry). Then, a nanoemulsion dosage form was prepared with a droplet size and droplet size distribution (SPAN) of 121 ± 3 nm and 0.96. After that, the dosage form of the nanogel was prepared; the nanoemulsion was gelified by the addition of 3.0% carboxymethyl cellulose. In addition, the successful loading of the essential oil into the nanoemulsion and nanogel was approved by ATR-FTIR (attenuated total reflection Fourier transform infrared) analysis. The IC50 values (half maximum inhibitory concentration) of the nanoemulsion and nanogel against A-375 human melanoma cells were 369.6 (497–335) and 127.2 (77–210) μg/mL. In addition, they indicated some degrees of an antioxidant activity. Interestingly, after treatment of Pseudomonas aeruginosa with 5000 µg/mL nanogel, bacterial growth was completely (∼100%) inhibited. In addition, the growth of Staphylococcus aureus after treatment with the 5000 μg/ml nanoemulsion was decreased by 80%. In addition, nanoemulsion and nanogel LC50 values for Anopheles stephensi larvae were attained as 43.91 (31–62) and 123.9 (111–137) µg/mL. Given the natural ingredients and promising efficacy, these nanodrugs can be regarded for further research against other pathogens or mosquito larvae. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2023 1 11 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Razie Ranjbar Elham Zarenezhad Abbas Abdollahi Marjan Nasrizadeh Samira Firooziyan Najmeh Namdar Mahmoud Osanloo Nanoemulsion and Nanogel Containing Cuminum cyminum L Essential Oil: Antioxidant, Anticancer, Antibacterial, and Antilarval Properties |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Cuminum cyminum L. is a widespread medicinal plant with a broad spectrum of biological activity. In the present study, the chemical structure of its essential oil was examined utilizing GC-MS analysis (gas chromatography-mass spectrometry). Then, a nanoemulsion dosage form was prepared with a droplet size and droplet size distribution (SPAN) of 121 ± 3 nm and 0.96. After that, the dosage form of the nanogel was prepared; the nanoemulsion was gelified by the addition of 3.0% carboxymethyl cellulose. In addition, the successful loading of the essential oil into the nanoemulsion and nanogel was approved by ATR-FTIR (attenuated total reflection Fourier transform infrared) analysis. The IC50 values (half maximum inhibitory concentration) of the nanoemulsion and nanogel against A-375 human melanoma cells were 369.6 (497–335) and 127.2 (77–210) μg/mL. In addition, they indicated some degrees of an antioxidant activity. Interestingly, after treatment of Pseudomonas aeruginosa with 5000 µg/mL nanogel, bacterial growth was completely (∼100%) inhibited. In addition, the growth of Staphylococcus aureus after treatment with the 5000 μg/ml nanoemulsion was decreased by 80%. In addition, nanoemulsion and nanogel LC50 values for Anopheles stephensi larvae were attained as 43.91 (31–62) and 123.9 (111–137) µg/mL. Given the natural ingredients and promising efficacy, these nanodrugs can be regarded for further research against other pathogens or mosquito larvae. |
format |
Article in Journal/Newspaper |
author |
Razie Ranjbar Elham Zarenezhad Abbas Abdollahi Marjan Nasrizadeh Samira Firooziyan Najmeh Namdar Mahmoud Osanloo |
author_facet |
Razie Ranjbar Elham Zarenezhad Abbas Abdollahi Marjan Nasrizadeh Samira Firooziyan Najmeh Namdar Mahmoud Osanloo |
author_sort |
Razie Ranjbar |
title |
Nanoemulsion and Nanogel Containing Cuminum cyminum L Essential Oil: Antioxidant, Anticancer, Antibacterial, and Antilarval Properties |
title_short |
Nanoemulsion and Nanogel Containing Cuminum cyminum L Essential Oil: Antioxidant, Anticancer, Antibacterial, and Antilarval Properties |
title_full |
Nanoemulsion and Nanogel Containing Cuminum cyminum L Essential Oil: Antioxidant, Anticancer, Antibacterial, and Antilarval Properties |
title_fullStr |
Nanoemulsion and Nanogel Containing Cuminum cyminum L Essential Oil: Antioxidant, Anticancer, Antibacterial, and Antilarval Properties |
title_full_unstemmed |
Nanoemulsion and Nanogel Containing Cuminum cyminum L Essential Oil: Antioxidant, Anticancer, Antibacterial, and Antilarval Properties |
title_sort |
nanoemulsion and nanogel containing cuminum cyminum l essential oil: antioxidant, anticancer, antibacterial, and antilarval properties |
publisher |
Hindawi Limited |
publishDate |
2023 |
url |
https://doi.org/10.1155/2023/5075581 https://doaj.org/article/80555e6df630435e977a030ba6ca67e2 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2023 (2023) |
op_relation |
http://dx.doi.org/10.1155/2023/5075581 https://doaj.org/toc/1687-9694 1687-9694 doi:10.1155/2023/5075581 https://doaj.org/article/80555e6df630435e977a030ba6ca67e2 |
op_doi |
https://doi.org/10.1155/2023/5075581 |
container_title |
Journal of Tropical Medicine |
container_volume |
2023 |
container_start_page |
1 |
op_container_end_page |
11 |
_version_ |
1766339504781656064 |