Etiology of diarrhea in older children, adolescents and adults: a systematic review.
BACKGROUND: Diarrhea is an important cause of morbidity and mortality in all regions of the world and among all ages, yet little is known about the fraction of diarrhea episodes and deaths due to each pathogen. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic literature review to identify a...
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ftdoajarticles:oai:doaj.org/article:804d47aa0b494af5bbee880efc6dbef1 2023-05-15T15:06:13+02:00 Etiology of diarrhea in older children, adolescents and adults: a systematic review. Christa L Fischer Walker David Sack Robert E Black 2010-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0000768 https://doaj.org/article/804d47aa0b494af5bbee880efc6dbef1 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC2914743?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000768 https://doaj.org/article/804d47aa0b494af5bbee880efc6dbef1 PLoS Neglected Tropical Diseases, Vol 4, Iss 8, p e768 (2010) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2010 ftdoajarticles https://doi.org/10.1371/journal.pntd.0000768 2022-12-31T11:48:03Z BACKGROUND: Diarrhea is an important cause of morbidity and mortality in all regions of the world and among all ages, yet little is known about the fraction of diarrhea episodes and deaths due to each pathogen. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic literature review to identify all papers reporting the proportion of diarrhea episodes with positive laboratory tests for at least one pathogen in inpatient, outpatient and community settings that met our inclusion and exclusion criteria. We identified a total of 25,701 papers with possible etiology data and after final screening included 22 papers that met all inclusion and exclusion criteria. Enterotoxigenic Escherichia coli and V. cholerae O1/O139 were the leading causes of hospitalizations. In outpatient settings, Salmonella spp., Shigella spp., and E. histolytica were the most frequently isolated pathogens. CONCLUSIONS/SIGNIFICANCE: This is the first systematic review which has considered the relative importance of multiple diarrhea pathogens. The few studies identified suggest that there is a great need for additional prospective studies around the world in these age groups to better understand the burden of disease and the variation by region. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 4 8 e768 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Christa L Fischer Walker David Sack Robert E Black Etiology of diarrhea in older children, adolescents and adults: a systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Diarrhea is an important cause of morbidity and mortality in all regions of the world and among all ages, yet little is known about the fraction of diarrhea episodes and deaths due to each pathogen. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a systematic literature review to identify all papers reporting the proportion of diarrhea episodes with positive laboratory tests for at least one pathogen in inpatient, outpatient and community settings that met our inclusion and exclusion criteria. We identified a total of 25,701 papers with possible etiology data and after final screening included 22 papers that met all inclusion and exclusion criteria. Enterotoxigenic Escherichia coli and V. cholerae O1/O139 were the leading causes of hospitalizations. In outpatient settings, Salmonella spp., Shigella spp., and E. histolytica were the most frequently isolated pathogens. CONCLUSIONS/SIGNIFICANCE: This is the first systematic review which has considered the relative importance of multiple diarrhea pathogens. The few studies identified suggest that there is a great need for additional prospective studies around the world in these age groups to better understand the burden of disease and the variation by region. |
format |
Article in Journal/Newspaper |
author |
Christa L Fischer Walker David Sack Robert E Black |
author_facet |
Christa L Fischer Walker David Sack Robert E Black |
author_sort |
Christa L Fischer Walker |
title |
Etiology of diarrhea in older children, adolescents and adults: a systematic review. |
title_short |
Etiology of diarrhea in older children, adolescents and adults: a systematic review. |
title_full |
Etiology of diarrhea in older children, adolescents and adults: a systematic review. |
title_fullStr |
Etiology of diarrhea in older children, adolescents and adults: a systematic review. |
title_full_unstemmed |
Etiology of diarrhea in older children, adolescents and adults: a systematic review. |
title_sort |
etiology of diarrhea in older children, adolescents and adults: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2010 |
url |
https://doi.org/10.1371/journal.pntd.0000768 https://doaj.org/article/804d47aa0b494af5bbee880efc6dbef1 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 4, Iss 8, p e768 (2010) |
op_relation |
http://europepmc.org/articles/PMC2914743?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0000768 https://doaj.org/article/804d47aa0b494af5bbee880efc6dbef1 |
op_doi |
https://doi.org/10.1371/journal.pntd.0000768 |
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PLoS Neglected Tropical Diseases |
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8 |
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e768 |
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