Simulation of the cost-effectiveness of malaria vaccines
Abstract Background A wide range of possible malaria vaccines is being considered and there is a need to identify which vaccines should be prioritized for clinical development. An important element of the information needed for this prioritization is a prediction of the cost-effectiveness of potenti...
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ftdoajarticles:oai:doaj.org/article:8016a33bcefd46b785ae400729fb2c37 2023-05-15T15:14:46+02:00 Simulation of the cost-effectiveness of malaria vaccines Tediosi Fabrizio Maire Nicolas Penny Melissa Studer Alain Smith Thomas A 2009-06-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-127 https://doaj.org/article/8016a33bcefd46b785ae400729fb2c37 EN eng BMC http://www.malariajournal.com/content/8/1/127 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-127 1475-2875 https://doaj.org/article/8016a33bcefd46b785ae400729fb2c37 Malaria Journal, Vol 8, Iss 1, p 127 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-127 2022-12-31T13:51:52Z Abstract Background A wide range of possible malaria vaccines is being considered and there is a need to identify which vaccines should be prioritized for clinical development. An important element of the information needed for this prioritization is a prediction of the cost-effectiveness of potential vaccines in the transmission settings in which they are likely to be deployed. This analysis needs to consider a range of delivery modalities to ensure that clinical development plans can be aligned with the most appropriate deployment strategies. Methods The simulations are based on a previously published individual-based stochastic model for the natural history and epidemiology of Plasmodium falciparum malaria. Three different vaccine types: pre-erythrocytic vaccines (PEV), blood stage vaccines (BSV), mosquito-stage transmission-blocking vaccines (MSTBV), and combinations of these, are considered each delivered via a range of delivery modalities (Expanded Programme of Immunization – EPI-, EPI with booster, and mass vaccination combined with EPI). The cost-effectiveness ratios presented are calculated for four health outcomes, for assumed vaccine prices of US$ 2 or US$ 10 per dose, projected over a 10-year period. Results The simulations suggest that PEV will be more cost-effective in low transmission settings, while BSV at higher transmission settings. Combinations of BSV and PEV are more efficient than PEV, especially in moderate to high transmission settings, while compared to BSV they are more cost-effective in moderate to low transmission settings. Combinations of MSTBV and PEV or PEV and BSV improve the effectiveness and the cost-effectiveness compared to PEV and BSV alone only when applied with EPI and mass vaccinations. Adding booster doses to the EPI is unlikely to be a cost-effective alternative to delivering vaccines via the EPI for any vaccine, while mass vaccination improves effectiveness, especially in low transmission settings, and is often a more efficient alternative to the EPI. However, the costs ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 127 |
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Directory of Open Access Journals: DOAJ Articles |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Tediosi Fabrizio Maire Nicolas Penny Melissa Studer Alain Smith Thomas A Simulation of the cost-effectiveness of malaria vaccines |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background A wide range of possible malaria vaccines is being considered and there is a need to identify which vaccines should be prioritized for clinical development. An important element of the information needed for this prioritization is a prediction of the cost-effectiveness of potential vaccines in the transmission settings in which they are likely to be deployed. This analysis needs to consider a range of delivery modalities to ensure that clinical development plans can be aligned with the most appropriate deployment strategies. Methods The simulations are based on a previously published individual-based stochastic model for the natural history and epidemiology of Plasmodium falciparum malaria. Three different vaccine types: pre-erythrocytic vaccines (PEV), blood stage vaccines (BSV), mosquito-stage transmission-blocking vaccines (MSTBV), and combinations of these, are considered each delivered via a range of delivery modalities (Expanded Programme of Immunization – EPI-, EPI with booster, and mass vaccination combined with EPI). The cost-effectiveness ratios presented are calculated for four health outcomes, for assumed vaccine prices of US$ 2 or US$ 10 per dose, projected over a 10-year period. Results The simulations suggest that PEV will be more cost-effective in low transmission settings, while BSV at higher transmission settings. Combinations of BSV and PEV are more efficient than PEV, especially in moderate to high transmission settings, while compared to BSV they are more cost-effective in moderate to low transmission settings. Combinations of MSTBV and PEV or PEV and BSV improve the effectiveness and the cost-effectiveness compared to PEV and BSV alone only when applied with EPI and mass vaccinations. Adding booster doses to the EPI is unlikely to be a cost-effective alternative to delivering vaccines via the EPI for any vaccine, while mass vaccination improves effectiveness, especially in low transmission settings, and is often a more efficient alternative to the EPI. However, the costs ... |
format |
Article in Journal/Newspaper |
author |
Tediosi Fabrizio Maire Nicolas Penny Melissa Studer Alain Smith Thomas A |
author_facet |
Tediosi Fabrizio Maire Nicolas Penny Melissa Studer Alain Smith Thomas A |
author_sort |
Tediosi Fabrizio |
title |
Simulation of the cost-effectiveness of malaria vaccines |
title_short |
Simulation of the cost-effectiveness of malaria vaccines |
title_full |
Simulation of the cost-effectiveness of malaria vaccines |
title_fullStr |
Simulation of the cost-effectiveness of malaria vaccines |
title_full_unstemmed |
Simulation of the cost-effectiveness of malaria vaccines |
title_sort |
simulation of the cost-effectiveness of malaria vaccines |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-127 https://doaj.org/article/8016a33bcefd46b785ae400729fb2c37 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 127 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/127 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-127 1475-2875 https://doaj.org/article/8016a33bcefd46b785ae400729fb2c37 |
op_doi |
https://doi.org/10.1186/1475-2875-8-127 |
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Malaria Journal |
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8 |
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127 |
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1766345186494906368 |