The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations.
Since the 2015 to 2016 outbreak in America, Zika virus (ZIKV) infected almost 900,000 patients. This international public health emergency was mainly associated with a significant increase in the number of newborns with congenital microcephaly and abnormal neurologic development, known as congenital...
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Online Access: | https://doi.org/10.1371/journal.pntd.0009575 https://doaj.org/article/7fbe4d0fdbd149c3ad5b304c834310e7 |
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ftdoajarticles:oai:doaj.org/article:7fbe4d0fdbd149c3ad5b304c834310e7 2023-05-15T15:09:39+02:00 The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations. Igor Salerno Filgueiras Amanda Torrentes de Carvalho Daniela Prado Cunha Dennyson Leandro Mathias da Fonseca Nadia El Khawanky Paula Paccielli Freire Gustavo Cabral-Miranda Lena F Schimke Niels Olsen Saraiva Camara Hans D Ochs Jean Pierre Schatzmann Peron Otávio Cabral-Marques Zilton Farias Meira de Vasconcelos 2021-08-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009575 https://doaj.org/article/7fbe4d0fdbd149c3ad5b304c834310e7 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009575 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009575 https://doaj.org/article/7fbe4d0fdbd149c3ad5b304c834310e7 PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009575 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009575 2022-12-31T08:00:15Z Since the 2015 to 2016 outbreak in America, Zika virus (ZIKV) infected almost 900,000 patients. This international public health emergency was mainly associated with a significant increase in the number of newborns with congenital microcephaly and abnormal neurologic development, known as congenital Zika syndrome (CZS). Furthermore, Guillain-Barré syndrome (GBS), a neuroimmune disorder of adults, has also been associated with ZIKV infection. Currently, the number of ZIKV-infected patients has decreased, and most of the cases recently reported present as a mild and self-limiting febrile illness. However, based on its natural history of a typical example of reemerging pathogen and the lack of specific therapeutic options against ZIKV infection, new outbreaks can occur worldwide, demanding the attention of researchers and government authorities. Here, we discuss the clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations. Several studies have confirmed the tropism of ZIKV for neural progenitor stem cells by demonstrating the presence of ZIKV in the central nervous system (CNS) during fetal development, eliciting a deleterious inflammatory response that compromises neurogenesis and brain formation. Of note, while the neuropathology of CZS can be due to a direct viral neuropathic effect, adults may develop neuroimmune manifestations such as GBS due to poorly understood mechanisms. Antiganglioside autoantibodies have been detected in multiple patients with ZIKV infection-associated GBS, suggesting a molecular mimicry. However, further additional immunopathological mechanisms remain to be uncovered, paving the way for new therapeutic strategies. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Barré ENVELOPE(-68.550,-68.550,-67.500,-67.500) PLOS Neglected Tropical Diseases 15 8 e0009575 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Igor Salerno Filgueiras Amanda Torrentes de Carvalho Daniela Prado Cunha Dennyson Leandro Mathias da Fonseca Nadia El Khawanky Paula Paccielli Freire Gustavo Cabral-Miranda Lena F Schimke Niels Olsen Saraiva Camara Hans D Ochs Jean Pierre Schatzmann Peron Otávio Cabral-Marques Zilton Farias Meira de Vasconcelos The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Since the 2015 to 2016 outbreak in America, Zika virus (ZIKV) infected almost 900,000 patients. This international public health emergency was mainly associated with a significant increase in the number of newborns with congenital microcephaly and abnormal neurologic development, known as congenital Zika syndrome (CZS). Furthermore, Guillain-Barré syndrome (GBS), a neuroimmune disorder of adults, has also been associated with ZIKV infection. Currently, the number of ZIKV-infected patients has decreased, and most of the cases recently reported present as a mild and self-limiting febrile illness. However, based on its natural history of a typical example of reemerging pathogen and the lack of specific therapeutic options against ZIKV infection, new outbreaks can occur worldwide, demanding the attention of researchers and government authorities. Here, we discuss the clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations. Several studies have confirmed the tropism of ZIKV for neural progenitor stem cells by demonstrating the presence of ZIKV in the central nervous system (CNS) during fetal development, eliciting a deleterious inflammatory response that compromises neurogenesis and brain formation. Of note, while the neuropathology of CZS can be due to a direct viral neuropathic effect, adults may develop neuroimmune manifestations such as GBS due to poorly understood mechanisms. Antiganglioside autoantibodies have been detected in multiple patients with ZIKV infection-associated GBS, suggesting a molecular mimicry. However, further additional immunopathological mechanisms remain to be uncovered, paving the way for new therapeutic strategies. |
format |
Article in Journal/Newspaper |
author |
Igor Salerno Filgueiras Amanda Torrentes de Carvalho Daniela Prado Cunha Dennyson Leandro Mathias da Fonseca Nadia El Khawanky Paula Paccielli Freire Gustavo Cabral-Miranda Lena F Schimke Niels Olsen Saraiva Camara Hans D Ochs Jean Pierre Schatzmann Peron Otávio Cabral-Marques Zilton Farias Meira de Vasconcelos |
author_facet |
Igor Salerno Filgueiras Amanda Torrentes de Carvalho Daniela Prado Cunha Dennyson Leandro Mathias da Fonseca Nadia El Khawanky Paula Paccielli Freire Gustavo Cabral-Miranda Lena F Schimke Niels Olsen Saraiva Camara Hans D Ochs Jean Pierre Schatzmann Peron Otávio Cabral-Marques Zilton Farias Meira de Vasconcelos |
author_sort |
Igor Salerno Filgueiras |
title |
The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations. |
title_short |
The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations. |
title_full |
The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations. |
title_fullStr |
The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations. |
title_full_unstemmed |
The clinical spectrum and immunopathological mechanisms underlying ZIKV-induced neurological manifestations. |
title_sort |
clinical spectrum and immunopathological mechanisms underlying zikv-induced neurological manifestations. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009575 https://doaj.org/article/7fbe4d0fdbd149c3ad5b304c834310e7 |
long_lat |
ENVELOPE(-68.550,-68.550,-67.500,-67.500) |
geographic |
Arctic Barré |
geographic_facet |
Arctic Barré |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 8, p e0009575 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009575 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009575 https://doaj.org/article/7fbe4d0fdbd149c3ad5b304c834310e7 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009575 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
8 |
container_start_page |
e0009575 |
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1766340804019748864 |