Clinical outcomes in patients with diabetes and stress hyperglycemia that developed SARS-CoV-2 infection
Introduction. Diabetes and stress hyperglycemia have been related with poorer clinical outcomes in patients infected by SARS-CoV-2 and at risk for severe disease. Objective. To evaluate clinical outcomes in three groups of patients (with diabetes, without diabetes and with stress hyperglycemia) with...
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ftdoajarticles:oai:doaj.org/article:7fa8fafa0f1545609e8020f7894995a0 2024-09-09T19:27:30+00:00 Clinical outcomes in patients with diabetes and stress hyperglycemia that developed SARS-CoV-2 infection Karen M. Fériz-Bonelo María B. Iriarte-Durán Oscar Giraldo Luis G. Parra -Lara Veline Martínez María A. Urbano Guillermo Guzmán 2024-05-01T00:00:00Z https://doi.org/10.7705/biomedica.7095 https://doaj.org/article/7fa8fafa0f1545609e8020f7894995a0 EN ES eng spa Instituto Nacional de Salud https://revistabiomedica.org/index.php/biomedica/article/view/7095 https://doaj.org/toc/0120-4157 https://doaj.org/toc/2590-7379 0120-4157 2590-7379 doi:10.7705/biomedica.7095 https://doaj.org/article/7fa8fafa0f1545609e8020f7894995a0 Biomédica: revista del Instituto Nacional de Salud, Vol 44, Iss Sp. 1, Pp 73-88 (2024) sars-cov-2 covid-19 diabetes mellitus hyperglycemia intensive care units mortality Medicine R Arctic medicine. Tropical medicine RC955-962 article 2024 ftdoajarticles https://doi.org/10.7705/biomedica.7095 2024-08-05T17:48:48Z Introduction. Diabetes and stress hyperglycemia have been related with poorer clinical outcomes in patients infected by SARS-CoV-2 and at risk for severe disease. Objective. To evaluate clinical outcomes in three groups of patients (with diabetes, without diabetes and with stress hyperglycemia) with SARS-CoV-2 infection. Materials and methods. A retrospective cohort study was conducted in Cali (Colombia). We included patients 18 years old or older with a diagnosis of SARS-CoV-2 infection, managed in the emergency room, hospitalization, or intensive care unit between March 2020 and December 2021. Immunocompromised patients and pregnant women were excluded. Patients were classified into three groups: without diabetes, with diabetes, and with stress hyperglycemia. A comparison between the groups was performed. Results. A total of 945 patients were included (59.6% without diabetes, 27% with diabetes, and 13.4% with stress hyperglycemia). Fifty-five-point three percent required intensive care unit management, with a higher need in patients with stress hyperglycemia (89.8%) and diabetes (67.1%), with no difference between these groups (p = 0.249). We identified a higher probability of death in the group with stress hyperglycemia versus the one without diabetes (adjusted OR = 8.12; 95% CI: 5.12-12.88; p < 0.01). Frequency of acute respiratory distress syndrome, need for invasive mechanical ventilation, use of vasopressors and inotropes, need for de novo renal replacement therapy, and mortality was higher in patients with metabolic alterations (diabetes and stress hyperglycemia). Conclusions. Diabetes and stress hyperglycemia were associated with worse clinical outcomes and mortality in patients with COVID-19. These patients should be identified early and considered them high risk at the COVID-19 diagnosis to mitigate adverse outcomes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Biomédica 44 Sp. 1 73 88 |
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English Spanish |
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sars-cov-2 covid-19 diabetes mellitus hyperglycemia intensive care units mortality Medicine R Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
sars-cov-2 covid-19 diabetes mellitus hyperglycemia intensive care units mortality Medicine R Arctic medicine. Tropical medicine RC955-962 Karen M. Fériz-Bonelo María B. Iriarte-Durán Oscar Giraldo Luis G. Parra -Lara Veline Martínez María A. Urbano Guillermo Guzmán Clinical outcomes in patients with diabetes and stress hyperglycemia that developed SARS-CoV-2 infection |
topic_facet |
sars-cov-2 covid-19 diabetes mellitus hyperglycemia intensive care units mortality Medicine R Arctic medicine. Tropical medicine RC955-962 |
description |
Introduction. Diabetes and stress hyperglycemia have been related with poorer clinical outcomes in patients infected by SARS-CoV-2 and at risk for severe disease. Objective. To evaluate clinical outcomes in three groups of patients (with diabetes, without diabetes and with stress hyperglycemia) with SARS-CoV-2 infection. Materials and methods. A retrospective cohort study was conducted in Cali (Colombia). We included patients 18 years old or older with a diagnosis of SARS-CoV-2 infection, managed in the emergency room, hospitalization, or intensive care unit between March 2020 and December 2021. Immunocompromised patients and pregnant women were excluded. Patients were classified into three groups: without diabetes, with diabetes, and with stress hyperglycemia. A comparison between the groups was performed. Results. A total of 945 patients were included (59.6% without diabetes, 27% with diabetes, and 13.4% with stress hyperglycemia). Fifty-five-point three percent required intensive care unit management, with a higher need in patients with stress hyperglycemia (89.8%) and diabetes (67.1%), with no difference between these groups (p = 0.249). We identified a higher probability of death in the group with stress hyperglycemia versus the one without diabetes (adjusted OR = 8.12; 95% CI: 5.12-12.88; p < 0.01). Frequency of acute respiratory distress syndrome, need for invasive mechanical ventilation, use of vasopressors and inotropes, need for de novo renal replacement therapy, and mortality was higher in patients with metabolic alterations (diabetes and stress hyperglycemia). Conclusions. Diabetes and stress hyperglycemia were associated with worse clinical outcomes and mortality in patients with COVID-19. These patients should be identified early and considered them high risk at the COVID-19 diagnosis to mitigate adverse outcomes. |
format |
Article in Journal/Newspaper |
author |
Karen M. Fériz-Bonelo María B. Iriarte-Durán Oscar Giraldo Luis G. Parra -Lara Veline Martínez María A. Urbano Guillermo Guzmán |
author_facet |
Karen M. Fériz-Bonelo María B. Iriarte-Durán Oscar Giraldo Luis G. Parra -Lara Veline Martínez María A. Urbano Guillermo Guzmán |
author_sort |
Karen M. Fériz-Bonelo |
title |
Clinical outcomes in patients with diabetes and stress hyperglycemia that developed SARS-CoV-2 infection |
title_short |
Clinical outcomes in patients with diabetes and stress hyperglycemia that developed SARS-CoV-2 infection |
title_full |
Clinical outcomes in patients with diabetes and stress hyperglycemia that developed SARS-CoV-2 infection |
title_fullStr |
Clinical outcomes in patients with diabetes and stress hyperglycemia that developed SARS-CoV-2 infection |
title_full_unstemmed |
Clinical outcomes in patients with diabetes and stress hyperglycemia that developed SARS-CoV-2 infection |
title_sort |
clinical outcomes in patients with diabetes and stress hyperglycemia that developed sars-cov-2 infection |
publisher |
Instituto Nacional de Salud |
publishDate |
2024 |
url |
https://doi.org/10.7705/biomedica.7095 https://doaj.org/article/7fa8fafa0f1545609e8020f7894995a0 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Biomédica: revista del Instituto Nacional de Salud, Vol 44, Iss Sp. 1, Pp 73-88 (2024) |
op_relation |
https://revistabiomedica.org/index.php/biomedica/article/view/7095 https://doaj.org/toc/0120-4157 https://doaj.org/toc/2590-7379 0120-4157 2590-7379 doi:10.7705/biomedica.7095 https://doaj.org/article/7fa8fafa0f1545609e8020f7894995a0 |
op_doi |
https://doi.org/10.7705/biomedica.7095 |
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Biomédica |
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44 |
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Sp. 1 |
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73 |
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88 |
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