Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010
OBJECTIVE: To present a global update of drug-resistant tuberculosis (TB) and explore trends in 1994-2010. METHODS: Data on drug resistance among new and previously treated TB patients, as reported by countries to the World Health Organization, were analysed. Such data are collected through surveys...
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ftdoajarticles:oai:doaj.org/article:7f7b0f1656df46f0893db5e20d33f64b 2024-09-15T18:18:56+00:00 Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 Matteo Zignol Wayne van Gemert Dennis Falzon Charalambos Sismanidis Philippe Glaziou Katherine Floyd Mario Raviglione https://doi.org/10.1590/S0042-96862012000200011 https://doaj.org/article/7f7b0f1656df46f0893db5e20d33f64b EN eng The World Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862012000200011&lng=en&tlng=en https://doaj.org/toc/0042-9686 0042-9686 doi:10.1590/S0042-96862012000200011 https://doaj.org/article/7f7b0f1656df46f0893db5e20d33f64b Bulletin of the World Health Organization, Vol 90, Iss 2, Pp 111-119 Public aspects of medicine RA1-1270 article ftdoajarticles https://doi.org/10.1590/S0042-96862012000200011 2024-08-05T17:49:55Z OBJECTIVE: To present a global update of drug-resistant tuberculosis (TB) and explore trends in 1994-2010. METHODS: Data on drug resistance among new and previously treated TB patients, as reported by countries to the World Health Organization, were analysed. Such data are collected through surveys of a representative sample of TB patients or surveillance systems based on routine drug susceptibility testing. Associations between multidrug-resistant TB (MDR-TB) and human immunodeficiency virus (HIV) infection and sex were explored through logistic regression. FINDINGS: In 2007-2010, 80 countries and 8 territories reported surveillance data. MDR-TB among new and previously treated cases was highest in the Russian Federation (Murmansk oblast, 28.9%) and the Republic of Moldova (65.1%), respectively. In three former Soviet Union countries and South Africa, more than 10% of the cases of MDR-TB were extensively drug-resistant. Globally, in 1994 to 2010 multidrug resistance was observed in 3.4% (95% confidence interval, CI: 1.9-5.0) of all new TB cases and in 19.8% (95% CI: 14.4-25.1) of previously treated TB cases. No overall associations between MDR-TB and HIV infection (odds ratio, OR: 1.4; 95% CI: 0.7-3.0) or sex (OR: 1.1; 95% CI: 0.8-1.4) were found. Between 1994 and 2010, MDR-TB rates in the general population increased in Botswana, Peru, the Republic of Korea and declined in Estonia, Latvia and the United States of America. CONCLUSION: The highest global rates of MDR-TB ever reported were documented in 2009 and 2010. Trends in MDR-TB are still unclear in most settings. Better surveillance or survey data are required, especially from Africa and India. Article in Journal/Newspaper Murmansk Oblast Directory of Open Access Journals: DOAJ Articles |
institution |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Public aspects of medicine RA1-1270 |
spellingShingle |
Public aspects of medicine RA1-1270 Matteo Zignol Wayne van Gemert Dennis Falzon Charalambos Sismanidis Philippe Glaziou Katherine Floyd Mario Raviglione Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
topic_facet |
Public aspects of medicine RA1-1270 |
description |
OBJECTIVE: To present a global update of drug-resistant tuberculosis (TB) and explore trends in 1994-2010. METHODS: Data on drug resistance among new and previously treated TB patients, as reported by countries to the World Health Organization, were analysed. Such data are collected through surveys of a representative sample of TB patients or surveillance systems based on routine drug susceptibility testing. Associations between multidrug-resistant TB (MDR-TB) and human immunodeficiency virus (HIV) infection and sex were explored through logistic regression. FINDINGS: In 2007-2010, 80 countries and 8 territories reported surveillance data. MDR-TB among new and previously treated cases was highest in the Russian Federation (Murmansk oblast, 28.9%) and the Republic of Moldova (65.1%), respectively. In three former Soviet Union countries and South Africa, more than 10% of the cases of MDR-TB were extensively drug-resistant. Globally, in 1994 to 2010 multidrug resistance was observed in 3.4% (95% confidence interval, CI: 1.9-5.0) of all new TB cases and in 19.8% (95% CI: 14.4-25.1) of previously treated TB cases. No overall associations between MDR-TB and HIV infection (odds ratio, OR: 1.4; 95% CI: 0.7-3.0) or sex (OR: 1.1; 95% CI: 0.8-1.4) were found. Between 1994 and 2010, MDR-TB rates in the general population increased in Botswana, Peru, the Republic of Korea and declined in Estonia, Latvia and the United States of America. CONCLUSION: The highest global rates of MDR-TB ever reported were documented in 2009 and 2010. Trends in MDR-TB are still unclear in most settings. Better surveillance or survey data are required, especially from Africa and India. |
format |
Article in Journal/Newspaper |
author |
Matteo Zignol Wayne van Gemert Dennis Falzon Charalambos Sismanidis Philippe Glaziou Katherine Floyd Mario Raviglione |
author_facet |
Matteo Zignol Wayne van Gemert Dennis Falzon Charalambos Sismanidis Philippe Glaziou Katherine Floyd Mario Raviglione |
author_sort |
Matteo Zignol |
title |
Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
title_short |
Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
title_full |
Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
title_fullStr |
Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
title_full_unstemmed |
Surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
title_sort |
surveillance of anti-tuberculosis drug resistance in the world: an updated analysis, 2007-2010 |
publisher |
The World Health Organization |
url |
https://doi.org/10.1590/S0042-96862012000200011 https://doaj.org/article/7f7b0f1656df46f0893db5e20d33f64b |
genre |
Murmansk Oblast |
genre_facet |
Murmansk Oblast |
op_source |
Bulletin of the World Health Organization, Vol 90, Iss 2, Pp 111-119 |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0042-96862012000200011&lng=en&tlng=en https://doaj.org/toc/0042-9686 0042-9686 doi:10.1590/S0042-96862012000200011 https://doaj.org/article/7f7b0f1656df46f0893db5e20d33f64b |
op_doi |
https://doi.org/10.1590/S0042-96862012000200011 |
_version_ |
1810457017986318336 |