Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog
Leishmaniasis has reemerged in recent years showing a wider geographic distribution and increased global incidence of human and canine disease than previously known. Dogs are the main domestic/peridomestic reservoir hosts of zoonotic visceral leishmaniasis caused by Leishmania infantum. Since the ev...
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ftdoajarticles:oai:doaj.org/article:7f6c0bf10b194878a3a28eeac770b702 2024-09-09T19:25:20+00:00 Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog Carla Maia Lenea Campino 2012-01-01T00:00:00Z https://doi.org/10.1155/2012/541571 https://doaj.org/article/7f6c0bf10b194878a3a28eeac770b702 EN eng Wiley http://dx.doi.org/10.1155/2012/541571 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/541571 https://doaj.org/article/7f6c0bf10b194878a3a28eeac770b702 Journal of Tropical Medicine, Vol 2012 (2012) Arctic medicine. Tropical medicine RC955-962 article 2012 ftdoajarticles https://doi.org/10.1155/2012/541571 2024-08-05T17:48:40Z Leishmaniasis has reemerged in recent years showing a wider geographic distribution and increased global incidence of human and canine disease than previously known. Dogs are the main domestic/peridomestic reservoir hosts of zoonotic visceral leishmaniasis caused by Leishmania infantum. Since the evolution of leishmaniasis and clinical appearance is a consequence of complex interactions between the parasite and host immune response, a profound knowledge about the immune profile developed in dog's infection is crucial for vaccine and immunomodulatory therapy design. The main goal of this paper is to compile the recent advances made on cytokine and phenotypic cell profiles in different tissues and organs of dogs infected with L. infantum. This paper also stressed that the knowledge of the immune responses developed, namely, in liver, lymph node, and spleen is very limited. All data emphasizes that more research on canine leishmaniasis is necessary for the development of new and efficacious tools to control zoonotic leishmaniasis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Tropical Medicine 2012 1 7 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Carla Maia Lenea Campino Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 |
description |
Leishmaniasis has reemerged in recent years showing a wider geographic distribution and increased global incidence of human and canine disease than previously known. Dogs are the main domestic/peridomestic reservoir hosts of zoonotic visceral leishmaniasis caused by Leishmania infantum. Since the evolution of leishmaniasis and clinical appearance is a consequence of complex interactions between the parasite and host immune response, a profound knowledge about the immune profile developed in dog's infection is crucial for vaccine and immunomodulatory therapy design. The main goal of this paper is to compile the recent advances made on cytokine and phenotypic cell profiles in different tissues and organs of dogs infected with L. infantum. This paper also stressed that the knowledge of the immune responses developed, namely, in liver, lymph node, and spleen is very limited. All data emphasizes that more research on canine leishmaniasis is necessary for the development of new and efficacious tools to control zoonotic leishmaniasis. |
format |
Article in Journal/Newspaper |
author |
Carla Maia Lenea Campino |
author_facet |
Carla Maia Lenea Campino |
author_sort |
Carla Maia |
title |
Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog |
title_short |
Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog |
title_full |
Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog |
title_fullStr |
Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog |
title_full_unstemmed |
Cytokine and Phenotypic Cell Profiles of Leishmania infantum Infection in the Dog |
title_sort |
cytokine and phenotypic cell profiles of leishmania infantum infection in the dog |
publisher |
Wiley |
publishDate |
2012 |
url |
https://doi.org/10.1155/2012/541571 https://doaj.org/article/7f6c0bf10b194878a3a28eeac770b702 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Tropical Medicine, Vol 2012 (2012) |
op_relation |
http://dx.doi.org/10.1155/2012/541571 https://doaj.org/toc/1687-9686 https://doaj.org/toc/1687-9694 1687-9686 1687-9694 doi:10.1155/2012/541571 https://doaj.org/article/7f6c0bf10b194878a3a28eeac770b702 |
op_doi |
https://doi.org/10.1155/2012/541571 |
container_title |
Journal of Tropical Medicine |
container_volume |
2012 |
container_start_page |
1 |
op_container_end_page |
7 |
_version_ |
1809895070458970112 |