Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality
ABSTRACT The Brazilian municipality of Rondonópolis, Mato Grosso State, represents an important visceral leishmaniasis (VL) endemic area. This study described epidemiological and clinical aspects of the occurrence, VL/HIV coinfection and lethality related to VL in Rondonópolis. Data from autochthono...
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ftdoajarticles:oai:doaj.org/article:7f05ae7205764057b80ecb20c722caae 2024-09-09T19:26:21+00:00 Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality João Gabriel Guimarães Luz Danilo Bueno Naves Amanda Gabriela de Carvalho Gilvani Alves Meira João Victor Leite Dias Cor Jesus Fernandes Fontes 2018-03-01T00:00:00Z https://doi.org/10.1590/s1678-9946201860012 https://doaj.org/article/7f05ae7205764057b80ecb20c722caae EN eng Universidade de São Paulo (USP) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652018005000205&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201860012 https://doaj.org/article/7f05ae7205764057b80ecb20c722caae Revista do Instituto de Medicina Tropical de São Paulo, Vol 60, Iss 0 (2018) Visceral leishmaniasis Epidemiology Lethality HIV Coinfection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2018 ftdoajarticles https://doi.org/10.1590/s1678-9946201860012 2024-08-05T17:49:31Z ABSTRACT The Brazilian municipality of Rondonópolis, Mato Grosso State, represents an important visceral leishmaniasis (VL) endemic area. This study described epidemiological and clinical aspects of the occurrence, VL/HIV coinfection and lethality related to VL in Rondonópolis. Data from autochthonous cases reported between 2011 and 2016 were obtained from official information systems. During this period, 81 autochthonous cases were reported, with decreasing incidence through 2016. Contrastingly, the lethality rate was 8.6% overall, but varied widely, reaching a peak (20%) in 2016. Almost 10% of patients had VL/HIVcoinfection. The occurrence of VL prevailed among men (56.8%), brown-skinned (49.4%), urban residents (92.6%), aged 0-4 years (33.3%). Housewives or retired (29.6%) were the most affected occupational groups. Lower age was the main difference among the total VL cases and those who were coinfected or died. Clinically, fever, weakness and splenomegaly were more frequent among all VL cases and VL/HIV coinfected individuals. Bacterial infections (p=0.001) and bleeding (p<0.001) were associated with death due to VL. Pentavalent antimonial and liposomal amphotericin B were the first choices for treatment among all VL cases (71.6%) and those who died (71.4%), respectively. VL/HIV patients were equally treated with both drugs. These findings may support control measures and demonstrate the need for further investigations. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Revista do Instituto de Medicina Tropical de São Paulo 60 0 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Visceral leishmaniasis Epidemiology Lethality HIV Coinfection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
spellingShingle |
Visceral leishmaniasis Epidemiology Lethality HIV Coinfection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 João Gabriel Guimarães Luz Danilo Bueno Naves Amanda Gabriela de Carvalho Gilvani Alves Meira João Victor Leite Dias Cor Jesus Fernandes Fontes Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality |
topic_facet |
Visceral leishmaniasis Epidemiology Lethality HIV Coinfection Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
ABSTRACT The Brazilian municipality of Rondonópolis, Mato Grosso State, represents an important visceral leishmaniasis (VL) endemic area. This study described epidemiological and clinical aspects of the occurrence, VL/HIV coinfection and lethality related to VL in Rondonópolis. Data from autochthonous cases reported between 2011 and 2016 were obtained from official information systems. During this period, 81 autochthonous cases were reported, with decreasing incidence through 2016. Contrastingly, the lethality rate was 8.6% overall, but varied widely, reaching a peak (20%) in 2016. Almost 10% of patients had VL/HIVcoinfection. The occurrence of VL prevailed among men (56.8%), brown-skinned (49.4%), urban residents (92.6%), aged 0-4 years (33.3%). Housewives or retired (29.6%) were the most affected occupational groups. Lower age was the main difference among the total VL cases and those who were coinfected or died. Clinically, fever, weakness and splenomegaly were more frequent among all VL cases and VL/HIV coinfected individuals. Bacterial infections (p=0.001) and bleeding (p<0.001) were associated with death due to VL. Pentavalent antimonial and liposomal amphotericin B were the first choices for treatment among all VL cases (71.6%) and those who died (71.4%), respectively. VL/HIV patients were equally treated with both drugs. These findings may support control measures and demonstrate the need for further investigations. |
format |
Article in Journal/Newspaper |
author |
João Gabriel Guimarães Luz Danilo Bueno Naves Amanda Gabriela de Carvalho Gilvani Alves Meira João Victor Leite Dias Cor Jesus Fernandes Fontes |
author_facet |
João Gabriel Guimarães Luz Danilo Bueno Naves Amanda Gabriela de Carvalho Gilvani Alves Meira João Victor Leite Dias Cor Jesus Fernandes Fontes |
author_sort |
João Gabriel Guimarães Luz |
title |
Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality |
title_short |
Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality |
title_full |
Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality |
title_fullStr |
Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality |
title_full_unstemmed |
Visceral leishmaniasis in a Brazilian endemic area: an overview of occurrence, HIV coinfection and lethality |
title_sort |
visceral leishmaniasis in a brazilian endemic area: an overview of occurrence, hiv coinfection and lethality |
publisher |
Universidade de São Paulo (USP) |
publishDate |
2018 |
url |
https://doi.org/10.1590/s1678-9946201860012 https://doaj.org/article/7f05ae7205764057b80ecb20c722caae |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista do Instituto de Medicina Tropical de São Paulo, Vol 60, Iss 0 (2018) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0036-46652018005000205&lng=en&tlng=en https://doaj.org/toc/1678-9946 1678-9946 doi:10.1590/s1678-9946201860012 https://doaj.org/article/7f05ae7205764057b80ecb20c722caae |
op_doi |
https://doi.org/10.1590/s1678-9946201860012 |
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Revista do Instituto de Medicina Tropical de São Paulo |
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60 |
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