Involvement of CD4⁺ Foxp3⁺ regulatory T cells in persistence of Leishmania donovani in the liver of alymphoplastic aly/aly mice.

• Published in: PLoS Neglected Tropical Diseases
• Main Authors: Saruda Tiwananthagorn, Kazuya Iwabuchi, Manabu Ato, Tatsuya Sakurai, Hirotomo Kato, Ken Katakura
• Format: Article in Journal/Newspaper
• Language: English
• Published: Public Library of Science (PLoS) 2012
• Subjects: Arctic medicine. Tropical medicine; RC955-962; Public aspects of medicine; RA1-1270; Arctic; Aly
• Online Access: https://doi.org/10.1371/journal.pntd.0001798; https://doaj.org/article/7ef5c2c303c843caaf29bf0829e99d03

Visceral leishmaniasis (VL) is a chronic and fatal disease in humans and dogs caused by the intracellular protozoan parasites, Leishmania donovani and L. infantum (L. chagasi). Relapse of disease is frequent in immunocompromised patients, in which the number of VL cases has been increasing recently....