The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations
Abstract Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however, the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi...
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ftdoajarticles:oai:doaj.org/article:7ee50377ba194efab4eaf249ea8dcb83 2023-05-15T17:42:39+02:00 The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations Ville Karhunen Tom A. Bond Verena Zuber Tuula Hurtig Irma Moilanen Marjo-Riitta Järvelin Marina Evangelou Alina Rodriguez 2021-09-01T00:00:00Z https://doi.org/10.1038/s41398-021-01584-4 https://doaj.org/article/7ee50377ba194efab4eaf249ea8dcb83 EN eng Nature Publishing Group https://doi.org/10.1038/s41398-021-01584-4 https://doaj.org/toc/2158-3188 doi:10.1038/s41398-021-01584-4 2158-3188 https://doaj.org/article/7ee50377ba194efab4eaf249ea8dcb83 Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 article 2021 ftdoajarticles https://doi.org/10.1038/s41398-021-01584-4 2022-12-31T07:15:48Z Abstract Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however, the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi-directional MR on ADHD liability and six obesity-related traits using summary statistics from the largest available meta-analyses of genome-wide association studies. We also examined the shared genetic aetiology between ADHD symptoms (inattention and hyperactivity) and body mass index (BMI) by PRS association analysis using longitudinal data from Northern Finland Birth Cohort 1986 (NFBC1986, n = 2984). Lastly, we examined the impact of the prenatal environment by association analysis of maternal pre-pregnancy BMI and offspring ADHD symptoms, adjusted for PRS of both traits, in NFBC1986 dataset. Through MR analyses, we found evidence for bidirectional causality between ADHD liability and obesity-related traits. PRS association analyses showed evidence for genetic overlap between ADHD symptoms and BMI. We found no evidence for a difference between inattention and hyperactivity symptoms, suggesting that neither symptom subtype is driving the association. We found evidence for association between maternal pre-pregnancy BMI and offspring ADHD symptoms after adjusting for both BMI and ADHD PRS (association p-value = 0.027 for inattention, p = 0.008 for hyperactivity). These results are consistent with the hypothesis that the co-occurrence between ADHD and obesity has both genetic and prenatal environmental origins. Article in Journal/Newspaper Northern Finland Directory of Open Access Journals: DOAJ Articles Translational Psychiatry 11 1 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
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Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Ville Karhunen Tom A. Bond Verena Zuber Tuula Hurtig Irma Moilanen Marjo-Riitta Järvelin Marina Evangelou Alina Rodriguez The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations |
topic_facet |
Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 |
description |
Abstract Attention-deficit/hyperactivity disorder (ADHD) often co-occurs with obesity, however, the potential causality between the traits remains unclear. We examined both genetic and prenatal evidence for causality using Mendelian Randomisation (MR) and polygenic risk scores (PRS). We conducted bi-directional MR on ADHD liability and six obesity-related traits using summary statistics from the largest available meta-analyses of genome-wide association studies. We also examined the shared genetic aetiology between ADHD symptoms (inattention and hyperactivity) and body mass index (BMI) by PRS association analysis using longitudinal data from Northern Finland Birth Cohort 1986 (NFBC1986, n = 2984). Lastly, we examined the impact of the prenatal environment by association analysis of maternal pre-pregnancy BMI and offspring ADHD symptoms, adjusted for PRS of both traits, in NFBC1986 dataset. Through MR analyses, we found evidence for bidirectional causality between ADHD liability and obesity-related traits. PRS association analyses showed evidence for genetic overlap between ADHD symptoms and BMI. We found no evidence for a difference between inattention and hyperactivity symptoms, suggesting that neither symptom subtype is driving the association. We found evidence for association between maternal pre-pregnancy BMI and offspring ADHD symptoms after adjusting for both BMI and ADHD PRS (association p-value = 0.027 for inattention, p = 0.008 for hyperactivity). These results are consistent with the hypothesis that the co-occurrence between ADHD and obesity has both genetic and prenatal environmental origins. |
format |
Article in Journal/Newspaper |
author |
Ville Karhunen Tom A. Bond Verena Zuber Tuula Hurtig Irma Moilanen Marjo-Riitta Järvelin Marina Evangelou Alina Rodriguez |
author_facet |
Ville Karhunen Tom A. Bond Verena Zuber Tuula Hurtig Irma Moilanen Marjo-Riitta Järvelin Marina Evangelou Alina Rodriguez |
author_sort |
Ville Karhunen |
title |
The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations |
title_short |
The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations |
title_full |
The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations |
title_fullStr |
The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations |
title_full_unstemmed |
The link between attention deficit hyperactivity disorder (ADHD) symptoms and obesity-related traits: genetic and prenatal explanations |
title_sort |
link between attention deficit hyperactivity disorder (adhd) symptoms and obesity-related traits: genetic and prenatal explanations |
publisher |
Nature Publishing Group |
publishDate |
2021 |
url |
https://doi.org/10.1038/s41398-021-01584-4 https://doaj.org/article/7ee50377ba194efab4eaf249ea8dcb83 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_source |
Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021) |
op_relation |
https://doi.org/10.1038/s41398-021-01584-4 https://doaj.org/toc/2158-3188 doi:10.1038/s41398-021-01584-4 2158-3188 https://doaj.org/article/7ee50377ba194efab4eaf249ea8dcb83 |
op_doi |
https://doi.org/10.1038/s41398-021-01584-4 |
container_title |
Translational Psychiatry |
container_volume |
11 |
container_issue |
1 |
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1766144550160564224 |