Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon.
BACKGROUND: Buruli ulcer is an infectious disease involving the skin, caused by Mycobacterium ulcerans. Its exact transmission mechanism remains unknown. Several arguments indicate a possible role for insects in its transmission. A previous case-control study in the Nyong valley region in central Ca...
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ftdoajarticles:oai:doaj.org/article:7e97287705cf4c1eb0c44eb72b4c0a48 2023-05-15T15:13:08+02:00 Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon. Jordi Landier Pascal Boisier Félix Fotso Piam Blanbin Noumen-Djeunga Joseph Simé Fidèle Gaetan Wantong Laurent Marsollier Arnaud Fontanet Sara Eyangoh 2011-11-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001392 https://doaj.org/article/7e97287705cf4c1eb0c44eb72b4c0a48 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3210760?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0001392 https://doaj.org/article/7e97287705cf4c1eb0c44eb72b4c0a48 PLoS Neglected Tropical Diseases, Vol 5, Iss 11, p e1392 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001392 2022-12-31T07:23:27Z BACKGROUND: Buruli ulcer is an infectious disease involving the skin, caused by Mycobacterium ulcerans. Its exact transmission mechanism remains unknown. Several arguments indicate a possible role for insects in its transmission. A previous case-control study in the Nyong valley region in central Cameroon showed an unexpected association between bed net use and protection against Buruli ulcer. We investigated whether this association persisted in a newly discovered endemic Buruli ulcer focus in Bankim, northwestern Cameroon. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a case-control study on 77 Buruli ulcer cases and 153 age-, gender- and village-matched controls. Participants were interviewed about their activities and habits. Multivariate conditional logistic regression analysis identified systematic use of a bed net (Odds-Ratio (OR) = 0.4, 95% Confidence Interval [95%CI] = [0.2-0.9], p-value (p) = 0.04), cleansing wounds with soap (OR [95%CI] = 0.1 [0.03-0.3], p<0.0001) and growing cassava (OR [95%CI] = 0.3 [0.2-0.7], p = 0.005) as independent protective factors. Independent risk factors were bathing in the Mbam River (OR [95%CI] = 6.9 [1.4-35], p = 0.02) and reporting scratch lesions after insect bites (OR [95%CI] = 2.7 [1.4-5.4], p = 0.004). The proportion of cases that could be prevented by systematic bed net use was 32%, and by adequate wound care was 34%. CONCLUSIONS/SIGNIFICANCE: Our study confirms that two previously identified factors, adequate wound care and bed net use, significantly decreased the risk of Buruli ulcer. These associations withstand generalization to different geographic, climatic and epidemiologic settings. Involvement of insects in the household environment, and the relationship between wound hygiene and M. ulcerans infection should now be investigated. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 11 e1392 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Jordi Landier Pascal Boisier Félix Fotso Piam Blanbin Noumen-Djeunga Joseph Simé Fidèle Gaetan Wantong Laurent Marsollier Arnaud Fontanet Sara Eyangoh Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Buruli ulcer is an infectious disease involving the skin, caused by Mycobacterium ulcerans. Its exact transmission mechanism remains unknown. Several arguments indicate a possible role for insects in its transmission. A previous case-control study in the Nyong valley region in central Cameroon showed an unexpected association between bed net use and protection against Buruli ulcer. We investigated whether this association persisted in a newly discovered endemic Buruli ulcer focus in Bankim, northwestern Cameroon. METHODOLOGY/PRINCIPAL FINDINGS: We conducted a case-control study on 77 Buruli ulcer cases and 153 age-, gender- and village-matched controls. Participants were interviewed about their activities and habits. Multivariate conditional logistic regression analysis identified systematic use of a bed net (Odds-Ratio (OR) = 0.4, 95% Confidence Interval [95%CI] = [0.2-0.9], p-value (p) = 0.04), cleansing wounds with soap (OR [95%CI] = 0.1 [0.03-0.3], p<0.0001) and growing cassava (OR [95%CI] = 0.3 [0.2-0.7], p = 0.005) as independent protective factors. Independent risk factors were bathing in the Mbam River (OR [95%CI] = 6.9 [1.4-35], p = 0.02) and reporting scratch lesions after insect bites (OR [95%CI] = 2.7 [1.4-5.4], p = 0.004). The proportion of cases that could be prevented by systematic bed net use was 32%, and by adequate wound care was 34%. CONCLUSIONS/SIGNIFICANCE: Our study confirms that two previously identified factors, adequate wound care and bed net use, significantly decreased the risk of Buruli ulcer. These associations withstand generalization to different geographic, climatic and epidemiologic settings. Involvement of insects in the household environment, and the relationship between wound hygiene and M. ulcerans infection should now be investigated. |
format |
Article in Journal/Newspaper |
author |
Jordi Landier Pascal Boisier Félix Fotso Piam Blanbin Noumen-Djeunga Joseph Simé Fidèle Gaetan Wantong Laurent Marsollier Arnaud Fontanet Sara Eyangoh |
author_facet |
Jordi Landier Pascal Boisier Félix Fotso Piam Blanbin Noumen-Djeunga Joseph Simé Fidèle Gaetan Wantong Laurent Marsollier Arnaud Fontanet Sara Eyangoh |
author_sort |
Jordi Landier |
title |
Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon. |
title_short |
Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon. |
title_full |
Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon. |
title_fullStr |
Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon. |
title_full_unstemmed |
Adequate wound care and use of bed nets as protective factors against Buruli Ulcer: results from a case control study in Cameroon. |
title_sort |
adequate wound care and use of bed nets as protective factors against buruli ulcer: results from a case control study in cameroon. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001392 https://doaj.org/article/7e97287705cf4c1eb0c44eb72b4c0a48 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 11, p e1392 (2011) |
op_relation |
http://europepmc.org/articles/PMC3210760?pdf=render https://doaj.org/toc/1935-2735 1935-2735 doi:10.1371/journal.pntd.0001392 https://doaj.org/article/7e97287705cf4c1eb0c44eb72b4c0a48 |
op_doi |
https://doi.org/10.1371/journal.pntd.0001392 |
container_title |
PLoS Neglected Tropical Diseases |
container_volume |
5 |
container_issue |
11 |
container_start_page |
e1392 |
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1766343723845681152 |