Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand.
Background/objectives Dengue fever is an important public health concern in most tropical and subtropical countries, and its prevention and control rest on vector surveillance and control. However, many aspects of dengue epidemiology remain unclear; in particular, the relationship between Aedes vect...
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ftdoajarticles:oai:doaj.org/article:7e0dab6495194217ad6cd3c7da951e6b 2023-05-15T15:15:45+02:00 Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand. Benedicte Fustec Thipruethai Phanitchat Mohammad Injamul Hoq Sirinart Aromseree Chamsai Pientong Kesorn Thaewnongiew Tipaya Ekalaksananan Michael J Bangs Vincent Corbel Neal Alexander Hans J Overgaard 2020-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008703 https://doaj.org/article/7e0dab6495194217ad6cd3c7da951e6b EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008703 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008703 https://doaj.org/article/7e0dab6495194217ad6cd3c7da951e6b PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008703 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008703 2022-12-31T05:07:34Z Background/objectives Dengue fever is an important public health concern in most tropical and subtropical countries, and its prevention and control rest on vector surveillance and control. However, many aspects of dengue epidemiology remain unclear; in particular, the relationship between Aedes vector abundance and dengue transmission risk. This study aims to identify entomological and immunological indices capable of discriminating between dengue case and control (non-case) houses, based on the assessment of candidate indices, as well as individual and household characteristics, as potential risk factors for acquiring dengue infection. Methods This prospective, hospital-based, case-control study was conducted in northeastern Thailand between June 2016 and August 2019. Immature and adult stage Aedes were collected at the houses of case and control patients, recruited from district hospitals, and at patients' neighboring houses. Blood samples were tested by RDT and PCR to detect dengue cases, and were processed with the Nterm-34 kDa salivary peptide to measure the human immune response to Aedes bites. Socioeconomic status, and other individual and household characteristics were analyzed as potential risk factors for dengue. Results Study findings showed complex relationships between entomological indices and dengue risk. The presence of DENV-infected Aedes at the patient house was associated with 4.2-fold higher odds of dengue. On the other hand, Aedes presence (irrespective of infectious status) in the patient's house was negatively associated with dengue. In addition, the human immune response to Aedes bites, was higher in control than in case patients and Aedes adult abundance and immature indices were higher in control than in case houses at the household and the neighboring level. Multivariable analysis showed that children aged 10-14 years old and those aged 15-25 years old had respectively 4.5-fold and 2.9-fold higher odds of dengue infection than those older than 25 years. Conclusion DENV infection in ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 10 e0008703 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Benedicte Fustec Thipruethai Phanitchat Mohammad Injamul Hoq Sirinart Aromseree Chamsai Pientong Kesorn Thaewnongiew Tipaya Ekalaksananan Michael J Bangs Vincent Corbel Neal Alexander Hans J Overgaard Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background/objectives Dengue fever is an important public health concern in most tropical and subtropical countries, and its prevention and control rest on vector surveillance and control. However, many aspects of dengue epidemiology remain unclear; in particular, the relationship between Aedes vector abundance and dengue transmission risk. This study aims to identify entomological and immunological indices capable of discriminating between dengue case and control (non-case) houses, based on the assessment of candidate indices, as well as individual and household characteristics, as potential risk factors for acquiring dengue infection. Methods This prospective, hospital-based, case-control study was conducted in northeastern Thailand between June 2016 and August 2019. Immature and adult stage Aedes were collected at the houses of case and control patients, recruited from district hospitals, and at patients' neighboring houses. Blood samples were tested by RDT and PCR to detect dengue cases, and were processed with the Nterm-34 kDa salivary peptide to measure the human immune response to Aedes bites. Socioeconomic status, and other individual and household characteristics were analyzed as potential risk factors for dengue. Results Study findings showed complex relationships between entomological indices and dengue risk. The presence of DENV-infected Aedes at the patient house was associated with 4.2-fold higher odds of dengue. On the other hand, Aedes presence (irrespective of infectious status) in the patient's house was negatively associated with dengue. In addition, the human immune response to Aedes bites, was higher in control than in case patients and Aedes adult abundance and immature indices were higher in control than in case houses at the household and the neighboring level. Multivariable analysis showed that children aged 10-14 years old and those aged 15-25 years old had respectively 4.5-fold and 2.9-fold higher odds of dengue infection than those older than 25 years. Conclusion DENV infection in ... |
format |
Article in Journal/Newspaper |
author |
Benedicte Fustec Thipruethai Phanitchat Mohammad Injamul Hoq Sirinart Aromseree Chamsai Pientong Kesorn Thaewnongiew Tipaya Ekalaksananan Michael J Bangs Vincent Corbel Neal Alexander Hans J Overgaard |
author_facet |
Benedicte Fustec Thipruethai Phanitchat Mohammad Injamul Hoq Sirinart Aromseree Chamsai Pientong Kesorn Thaewnongiew Tipaya Ekalaksananan Michael J Bangs Vincent Corbel Neal Alexander Hans J Overgaard |
author_sort |
Benedicte Fustec |
title |
Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand. |
title_short |
Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand. |
title_full |
Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand. |
title_fullStr |
Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand. |
title_full_unstemmed |
Complex relationships between Aedes vectors, socio-economics and dengue transmission-Lessons learned from a case-control study in northeastern Thailand. |
title_sort |
complex relationships between aedes vectors, socio-economics and dengue transmission-lessons learned from a case-control study in northeastern thailand. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008703 https://doaj.org/article/7e0dab6495194217ad6cd3c7da951e6b |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 14, Iss 10, p e0008703 (2020) |
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https://doi.org/10.1371/journal.pntd.0008703 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008703 https://doaj.org/article/7e0dab6495194217ad6cd3c7da951e6b |
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https://doi.org/10.1371/journal.pntd.0008703 |
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PLOS Neglected Tropical Diseases |
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e0008703 |
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