No Association between Visfatin Gene Variants and Metabolic Traits in the Newfoundland Population
Objective Visfatin is a novel adipokine initially reported to exhibit insulin-mimetic effects that increase insulin sensitivity. Further studies indicate it may also be associated with obesity, serum lipids, and systemic inflammation. At the current time, the role of genetic variation in the visfati...
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ftdoajarticles:oai:doaj.org/article:7d3a1998789849bfadca62c693714726 2023-05-15T17:21:13+02:00 No Association between Visfatin Gene Variants and Metabolic Traits in the Newfoundland Population Jennifer L Shea JC Loredo-Osti Guang Sun 2010-01-01T00:00:00Z https://doi.org/10.4137/GEG.S5337 https://doaj.org/article/7d3a1998789849bfadca62c693714726 EN eng SAGE Publishing https://doi.org/10.4137/GEG.S5337 https://doaj.org/toc/1179-237X 1179-237X doi:10.4137/GEG.S5337 https://doaj.org/article/7d3a1998789849bfadca62c693714726 Genetics and Epigenetics, Vol 3 (2010) Genetics QH426-470 article 2010 ftdoajarticles https://doi.org/10.4137/GEG.S5337 2022-12-31T15:00:52Z Objective Visfatin is a novel adipokine initially reported to exhibit insulin-mimetic effects that increase insulin sensitivity. Further studies indicate it may also be associated with obesity, serum lipids, and systemic inflammation. At the current time, the role of genetic variation in the visfatin gene (NAMPT) on these parameters is not clear. In the present study, we examined the association between 10 SNPs in NAMPT and insulin resistance, obesity, serum lipids and hsCRP levels. Research design and methods A total of 1838 subjects (413 men, 1425 women) were recruited from the ongoing CODING Study. All subjects were from the genetically homogenous population of Newfoundland and Labrador, Canada. BMI, waist circumference, waist-to-hip ratio, and body fat percentage (determined using DXA) were measured for all subjects. Serum glucose, insulin, HOMA IR , HOMAβ, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and hsCRP were also determined after a 12-hour fast. Ten SNPs in NAMPT were genotyped using TaqMan validated or functionally tested SNP genotyping assays including rs7789066 (A > G 5′ flanking region), rs3801266 (A > G intron), rs6963243 (G > C intron), rs2058539 (A > C intron), rs6947766 (C > T intron), rs4730153 (G > A intron), rs10808150 (G > A intron), rs2098291 (C > T intron), rs10953502 (T > C intron), and rs10953501 (A > G 3′ UTR). Results We observed no significant associations between any of the variants sites and any parameter of insulin resistance, body composition, serum lipids or hsCRP under an additive model with age and gender included as covariates. This was also true when both dominant and recessive models were applied. Conclusions Our results do not support a significant role for variations in NAMPT with differences in the measured variables in the Newfoundland population. Article in Journal/Newspaper Newfoundland Directory of Open Access Journals: DOAJ Articles Canada Newfoundland Genetics & Epigenetics 3 GEG.S5337 |
institution |
Open Polar |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Genetics QH426-470 |
spellingShingle |
Genetics QH426-470 Jennifer L Shea JC Loredo-Osti Guang Sun No Association between Visfatin Gene Variants and Metabolic Traits in the Newfoundland Population |
topic_facet |
Genetics QH426-470 |
description |
Objective Visfatin is a novel adipokine initially reported to exhibit insulin-mimetic effects that increase insulin sensitivity. Further studies indicate it may also be associated with obesity, serum lipids, and systemic inflammation. At the current time, the role of genetic variation in the visfatin gene (NAMPT) on these parameters is not clear. In the present study, we examined the association between 10 SNPs in NAMPT and insulin resistance, obesity, serum lipids and hsCRP levels. Research design and methods A total of 1838 subjects (413 men, 1425 women) were recruited from the ongoing CODING Study. All subjects were from the genetically homogenous population of Newfoundland and Labrador, Canada. BMI, waist circumference, waist-to-hip ratio, and body fat percentage (determined using DXA) were measured for all subjects. Serum glucose, insulin, HOMA IR , HOMAβ, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides and hsCRP were also determined after a 12-hour fast. Ten SNPs in NAMPT were genotyped using TaqMan validated or functionally tested SNP genotyping assays including rs7789066 (A > G 5′ flanking region), rs3801266 (A > G intron), rs6963243 (G > C intron), rs2058539 (A > C intron), rs6947766 (C > T intron), rs4730153 (G > A intron), rs10808150 (G > A intron), rs2098291 (C > T intron), rs10953502 (T > C intron), and rs10953501 (A > G 3′ UTR). Results We observed no significant associations between any of the variants sites and any parameter of insulin resistance, body composition, serum lipids or hsCRP under an additive model with age and gender included as covariates. This was also true when both dominant and recessive models were applied. Conclusions Our results do not support a significant role for variations in NAMPT with differences in the measured variables in the Newfoundland population. |
format |
Article in Journal/Newspaper |
author |
Jennifer L Shea JC Loredo-Osti Guang Sun |
author_facet |
Jennifer L Shea JC Loredo-Osti Guang Sun |
author_sort |
Jennifer L Shea |
title |
No Association between Visfatin Gene Variants and Metabolic Traits in the Newfoundland Population |
title_short |
No Association between Visfatin Gene Variants and Metabolic Traits in the Newfoundland Population |
title_full |
No Association between Visfatin Gene Variants and Metabolic Traits in the Newfoundland Population |
title_fullStr |
No Association between Visfatin Gene Variants and Metabolic Traits in the Newfoundland Population |
title_full_unstemmed |
No Association between Visfatin Gene Variants and Metabolic Traits in the Newfoundland Population |
title_sort |
no association between visfatin gene variants and metabolic traits in the newfoundland population |
publisher |
SAGE Publishing |
publishDate |
2010 |
url |
https://doi.org/10.4137/GEG.S5337 https://doaj.org/article/7d3a1998789849bfadca62c693714726 |
geographic |
Canada Newfoundland |
geographic_facet |
Canada Newfoundland |
genre |
Newfoundland |
genre_facet |
Newfoundland |
op_source |
Genetics and Epigenetics, Vol 3 (2010) |
op_relation |
https://doi.org/10.4137/GEG.S5337 https://doaj.org/toc/1179-237X 1179-237X doi:10.4137/GEG.S5337 https://doaj.org/article/7d3a1998789849bfadca62c693714726 |
op_doi |
https://doi.org/10.4137/GEG.S5337 |
container_title |
Genetics & Epigenetics |
container_volume |
3 |
container_start_page |
GEG.S5337 |
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1766104714248716288 |