Assessing the burden of pregnancy-associated malaria under changing transmission settings
Abstract Background The clinical presentation of pregnancy-associated malaria, or PAM, depends crucially on the particular epidemiological settings. This can potentially lead to an underestimation of its overall burden on the female population, especially in regions prone to epidemic outbreaks and w...
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ftdoajarticles:oai:doaj.org/article:7d2f622e1a5846f697b905c335a0bc99 2023-05-15T15:06:34+02:00 Assessing the burden of pregnancy-associated malaria under changing transmission settings Gupta Sunetra Bamford Paul Bouma Menno J Recker Mario Dobson Andy P 2009-10-01T00:00:00Z https://doi.org/10.1186/1475-2875-8-245 https://doaj.org/article/7d2f622e1a5846f697b905c335a0bc99 EN eng BMC http://www.malariajournal.com/content/8/1/245 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-245 1475-2875 https://doaj.org/article/7d2f622e1a5846f697b905c335a0bc99 Malaria Journal, Vol 8, Iss 1, p 245 (2009) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2009 ftdoajarticles https://doi.org/10.1186/1475-2875-8-245 2022-12-31T00:39:05Z Abstract Background The clinical presentation of pregnancy-associated malaria, or PAM, depends crucially on the particular epidemiological settings. This can potentially lead to an underestimation of its overall burden on the female population, especially in regions prone to epidemic outbreaks and where malaria transmission is generally low. Methods Here, by re-examining historical data, it is demonstrated how excess female mortality can be used to evaluate the burden of PAM. A simple mathematical model is then developed to highlight the contrasting signatures of PAM within the endemicity spectrum and to show how PAM is influenced by the intensity and stability of transmission. Results Both the data and the model show that maternal malaria has a huge impact on the female population. This is particularly pronounced in low-transmission settings during epidemic outbreaks where excess female mortality/morbidity can by far exceed that of a similar endemic setting. Conclusion The results presented here call for active intervention measures not only in highly endemic regions but also, or in particular, in areas where malaria transmission is low and seasonal. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 8 1 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Gupta Sunetra Bamford Paul Bouma Menno J Recker Mario Dobson Andy P Assessing the burden of pregnancy-associated malaria under changing transmission settings |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background The clinical presentation of pregnancy-associated malaria, or PAM, depends crucially on the particular epidemiological settings. This can potentially lead to an underestimation of its overall burden on the female population, especially in regions prone to epidemic outbreaks and where malaria transmission is generally low. Methods Here, by re-examining historical data, it is demonstrated how excess female mortality can be used to evaluate the burden of PAM. A simple mathematical model is then developed to highlight the contrasting signatures of PAM within the endemicity spectrum and to show how PAM is influenced by the intensity and stability of transmission. Results Both the data and the model show that maternal malaria has a huge impact on the female population. This is particularly pronounced in low-transmission settings during epidemic outbreaks where excess female mortality/morbidity can by far exceed that of a similar endemic setting. Conclusion The results presented here call for active intervention measures not only in highly endemic regions but also, or in particular, in areas where malaria transmission is low and seasonal. |
format |
Article in Journal/Newspaper |
author |
Gupta Sunetra Bamford Paul Bouma Menno J Recker Mario Dobson Andy P |
author_facet |
Gupta Sunetra Bamford Paul Bouma Menno J Recker Mario Dobson Andy P |
author_sort |
Gupta Sunetra |
title |
Assessing the burden of pregnancy-associated malaria under changing transmission settings |
title_short |
Assessing the burden of pregnancy-associated malaria under changing transmission settings |
title_full |
Assessing the burden of pregnancy-associated malaria under changing transmission settings |
title_fullStr |
Assessing the burden of pregnancy-associated malaria under changing transmission settings |
title_full_unstemmed |
Assessing the burden of pregnancy-associated malaria under changing transmission settings |
title_sort |
assessing the burden of pregnancy-associated malaria under changing transmission settings |
publisher |
BMC |
publishDate |
2009 |
url |
https://doi.org/10.1186/1475-2875-8-245 https://doaj.org/article/7d2f622e1a5846f697b905c335a0bc99 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 8, Iss 1, p 245 (2009) |
op_relation |
http://www.malariajournal.com/content/8/1/245 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-8-245 1475-2875 https://doaj.org/article/7d2f622e1a5846f697b905c335a0bc99 |
op_doi |
https://doi.org/10.1186/1475-2875-8-245 |
container_title |
Malaria Journal |
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8 |
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1 |
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1766338155611422720 |