Protein-species quantitative venomics: looking through a crystal ball
Abstract In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of t...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1186/s40409-017-0116-9 https://doaj.org/article/7d1c043f647b42c9aeef5d749bd73928 |
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ftdoajarticles:oai:doaj.org/article:7d1c043f647b42c9aeef5d749bd73928 2023-05-15T15:05:09+02:00 Protein-species quantitative venomics: looking through a crystal ball Juan J. Calvete Daniel Petras Francisco Calderón-Celis Bruno Lomonte Jorge Ruiz Encinar Alfredo Sanz-Medel 2017-04-01T00:00:00Z https://doi.org/10.1186/s40409-017-0116-9 https://doaj.org/article/7d1c043f647b42c9aeef5d749bd73928 EN eng SciELO http://link.springer.com/article/10.1186/s40409-017-0116-9 https://doaj.org/toc/1678-9199 doi:10.1186/s40409-017-0116-9 1678-9199 https://doaj.org/article/7d1c043f647b42c9aeef5d749bd73928 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 23, Iss 1, Pp 1-9 (2017) Snake venomics Top-down proteomics Top-down venomics Protein species-resolved venomics Absolute quantification Inductively coupled plasma mass spectrometry Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2017 ftdoajarticles https://doi.org/10.1186/s40409-017-0116-9 2022-12-31T15:58:29Z Abstract In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used here to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal of Proteomics “Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts” published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a venom. This short essay reflects the authors’ view of the immediate future in this direction for the proteomic analysis of venoms, particularly of snakes. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 23 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Snake venomics Top-down proteomics Top-down venomics Protein species-resolved venomics Absolute quantification Inductively coupled plasma mass spectrometry Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Snake venomics Top-down proteomics Top-down venomics Protein species-resolved venomics Absolute quantification Inductively coupled plasma mass spectrometry Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 Juan J. Calvete Daniel Petras Francisco Calderón-Celis Bruno Lomonte Jorge Ruiz Encinar Alfredo Sanz-Medel Protein-species quantitative venomics: looking through a crystal ball |
topic_facet |
Snake venomics Top-down proteomics Top-down venomics Protein species-resolved venomics Absolute quantification Inductively coupled plasma mass spectrometry Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
Abstract In this paper we discuss recent significant developments in the field of venom research, specifically the emergence of top-down proteomic applications that allow achieving compositional resolution at the level of the protein species present in the venom, and the absolute quantification of the venom proteins (the term “protein species” is used here to refer to all the different molecular forms in which a protein can be found. Please consult the special issue of Jornal of Proteomics “Towards deciphering proteomes via the proteoform, protein speciation, moonlighting and protein code concepts” published in 2016, vol. 134, pages 1-202). Challenges remain to be solved in order to achieve a compact and automated platform with which to routinely carry out comprehensive quantitative analysis of all toxins present in a venom. This short essay reflects the authors’ view of the immediate future in this direction for the proteomic analysis of venoms, particularly of snakes. |
format |
Article in Journal/Newspaper |
author |
Juan J. Calvete Daniel Petras Francisco Calderón-Celis Bruno Lomonte Jorge Ruiz Encinar Alfredo Sanz-Medel |
author_facet |
Juan J. Calvete Daniel Petras Francisco Calderón-Celis Bruno Lomonte Jorge Ruiz Encinar Alfredo Sanz-Medel |
author_sort |
Juan J. Calvete |
title |
Protein-species quantitative venomics: looking through a crystal ball |
title_short |
Protein-species quantitative venomics: looking through a crystal ball |
title_full |
Protein-species quantitative venomics: looking through a crystal ball |
title_fullStr |
Protein-species quantitative venomics: looking through a crystal ball |
title_full_unstemmed |
Protein-species quantitative venomics: looking through a crystal ball |
title_sort |
protein-species quantitative venomics: looking through a crystal ball |
publisher |
SciELO |
publishDate |
2017 |
url |
https://doi.org/10.1186/s40409-017-0116-9 https://doaj.org/article/7d1c043f647b42c9aeef5d749bd73928 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 23, Iss 1, Pp 1-9 (2017) |
op_relation |
http://link.springer.com/article/10.1186/s40409-017-0116-9 https://doaj.org/toc/1678-9199 doi:10.1186/s40409-017-0116-9 1678-9199 https://doaj.org/article/7d1c043f647b42c9aeef5d749bd73928 |
op_doi |
https://doi.org/10.1186/s40409-017-0116-9 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
23 |
container_issue |
1 |
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1766336897532035072 |