The frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments
Objective: To determine the prevalence and antimicrobial resistance rates of nosocomial pathogens isolated from cancer patients and hospital environments. Methods: A descriptive cross-sectional study was conducted between December 2010 to May 2013 at Radiation and Isotopes Centre of Khartoum, Sudan....
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:7cd24be5537a4c6fbd5dc0bb1810a779 2023-05-15T15:11:56+02:00 The frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments Aymen Mudawe Nurain Naser Eldin Bilal Mutasim Elhadi Ibrahim 2015-12-01T00:00:00Z https://doi.org/10.1016/j.apjtb.2015.09.015 https://doaj.org/article/7cd24be5537a4c6fbd5dc0bb1810a779 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115002270 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.09.015 https://doaj.org/article/7cd24be5537a4c6fbd5dc0bb1810a779 Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 12, Pp 1055-1059 (2015) Nosocomial pathogens Cancer patients Hospital environments Resistance rates Sudan Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2015 ftdoajarticles https://doi.org/10.1016/j.apjtb.2015.09.015 2022-12-31T00:40:42Z Objective: To determine the prevalence and antimicrobial resistance rates of nosocomial pathogens isolated from cancer patients and hospital environments. Methods: A descriptive cross-sectional study was conducted between December 2010 to May 2013 at Radiation and Isotopes Centre of Khartoum, Sudan. A total of 1503 samples (505 clinical and 998 environmental) were examined. Isolates were identified, and their antimicrobial susceptibility was determined using standard laboratory procedures. Results: Out of 505 clinical samples, nosocomial pathogens were found as 48.1%. Among hospital environment samples, bacterial contaminants were detected in 29.7% of samples. The main microorganisms recovered from cancer patients were Proteus spp. (23.5%), Escherichia coli (22.2%), Pseudomonas aeruginosa (P. aeruginosa) (21.0%) and Staphylococcus aureus (20.2%). The most frequent isolates from hospital environments were Bacillus spp. (50.0%), Staphylococcus aureus (14.2%) and P. aeruginosa (11.5%). The proportions of resistance among Gram-negative pathogens from cancer patients were high for ampicillin, cefotaxime, ceftazidime and ceftriaxone. Moderate resistance rates were recorded to ciprofloxacin, such as 51.0% for P. aeruginosa, 21.7% for Klebsiella pneumoniae and 55.5% for Escherichia coli. Except Klebsiella, there were no significant differences (P ≥ 0.05) of resistance rates between Gram-negative isolates from cancer patients to those from the hospital environments. The proportions of extended-spectrum β-lactamase producing isolates from cancer patients were not differ significantly (P = 0.763) from those collected from the hospital environments (49.2%; 91/185 vs. 47%; 32/68). Conclusions: The prevalence of nosocomial infection among cancer patients was high (48.1%) with the increasing of antimicrobial resistance rates. Hospital environments are potential reservoirs for nosocomial infections, which calls for intervention program to reduce environmental transmission of pathogens. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 5 12 1055 1059 |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Nosocomial pathogens Cancer patients Hospital environments Resistance rates Sudan Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Nosocomial pathogens Cancer patients Hospital environments Resistance rates Sudan Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Aymen Mudawe Nurain Naser Eldin Bilal Mutasim Elhadi Ibrahim The frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments |
topic_facet |
Nosocomial pathogens Cancer patients Hospital environments Resistance rates Sudan Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To determine the prevalence and antimicrobial resistance rates of nosocomial pathogens isolated from cancer patients and hospital environments. Methods: A descriptive cross-sectional study was conducted between December 2010 to May 2013 at Radiation and Isotopes Centre of Khartoum, Sudan. A total of 1503 samples (505 clinical and 998 environmental) were examined. Isolates were identified, and their antimicrobial susceptibility was determined using standard laboratory procedures. Results: Out of 505 clinical samples, nosocomial pathogens were found as 48.1%. Among hospital environment samples, bacterial contaminants were detected in 29.7% of samples. The main microorganisms recovered from cancer patients were Proteus spp. (23.5%), Escherichia coli (22.2%), Pseudomonas aeruginosa (P. aeruginosa) (21.0%) and Staphylococcus aureus (20.2%). The most frequent isolates from hospital environments were Bacillus spp. (50.0%), Staphylococcus aureus (14.2%) and P. aeruginosa (11.5%). The proportions of resistance among Gram-negative pathogens from cancer patients were high for ampicillin, cefotaxime, ceftazidime and ceftriaxone. Moderate resistance rates were recorded to ciprofloxacin, such as 51.0% for P. aeruginosa, 21.7% for Klebsiella pneumoniae and 55.5% for Escherichia coli. Except Klebsiella, there were no significant differences (P ≥ 0.05) of resistance rates between Gram-negative isolates from cancer patients to those from the hospital environments. The proportions of extended-spectrum β-lactamase producing isolates from cancer patients were not differ significantly (P = 0.763) from those collected from the hospital environments (49.2%; 91/185 vs. 47%; 32/68). Conclusions: The prevalence of nosocomial infection among cancer patients was high (48.1%) with the increasing of antimicrobial resistance rates. Hospital environments are potential reservoirs for nosocomial infections, which calls for intervention program to reduce environmental transmission of pathogens. |
format |
Article in Journal/Newspaper |
author |
Aymen Mudawe Nurain Naser Eldin Bilal Mutasim Elhadi Ibrahim |
author_facet |
Aymen Mudawe Nurain Naser Eldin Bilal Mutasim Elhadi Ibrahim |
author_sort |
Aymen Mudawe Nurain |
title |
The frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments |
title_short |
The frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments |
title_full |
The frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments |
title_fullStr |
The frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments |
title_full_unstemmed |
The frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments |
title_sort |
frequency and antimicrobial resistance patterns of nosocomial pathogens recovered from cancer patients and hospital environments |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2015 |
url |
https://doi.org/10.1016/j.apjtb.2015.09.015 https://doaj.org/article/7cd24be5537a4c6fbd5dc0bb1810a779 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 5, Iss 12, Pp 1055-1059 (2015) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115002270 https://doaj.org/toc/2221-1691 2221-1691 doi:10.1016/j.apjtb.2015.09.015 https://doaj.org/article/7cd24be5537a4c6fbd5dc0bb1810a779 |
op_doi |
https://doi.org/10.1016/j.apjtb.2015.09.015 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
5 |
container_issue |
12 |
container_start_page |
1055 |
op_container_end_page |
1059 |
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1766342703952429056 |