Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya
Abstract Background Malaria is the commonest cause of childhood morbidity in Western Kenya with varied heamatological consequences. The t study sought to elucidate the haemotological changes in children infected with malaria and their impact on improved diagnosis and therapy of childhood malaria. Me...
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ftdoajarticles:oai:doaj.org/article:7cb9b70c463e49c0ac6cfcba4dc2e4ca 2023-05-15T15:09:23+02:00 Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya Hongo Gordon Gaddy Charla Walsh Douglas Maina Robert N Waitumbi John Otieno Lucas Jones David Ogutu Bernhards R 2010-12-01T00:00:00Z https://doi.org/10.1186/1475-2875-9-S3-S4 https://doaj.org/article/7cb9b70c463e49c0ac6cfcba4dc2e4ca EN eng BMC https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-S3-S4 1475-2875 https://doaj.org/article/7cb9b70c463e49c0ac6cfcba4dc2e4ca Malaria Journal, Vol 9, Iss Suppl 3, p S4 (2010) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2010 ftdoajarticles https://doi.org/10.1186/1475-2875-9-S3-S4 2022-12-31T12:56:31Z Abstract Background Malaria is the commonest cause of childhood morbidity in Western Kenya with varied heamatological consequences. The t study sought to elucidate the haemotological changes in children infected with malaria and their impact on improved diagnosis and therapy of childhood malaria. Methods Haematological parameters in 961 children, including 523 malaria-infected and 438 non-malaria infected, living in Kisumu West District, an area of malaria holoendemic transmission in Western Kenya were evaluated. Results The following parameters were significantly lower in malaria-infected children; platelets, lymphocytes, eosinophils, red blood cell count and haemoglobin (Hb), while absolute monocyte and neutrophil counts, and mean platelet volume (MPV) were higher in comparison to non-malaria infected children. Children with platelet counts of <150,000/uL were 13.8 times (odds ratio) more likely to have malaria. Thrombocytopaenia was present in 49% of malaria-infected children and was associated with high parasitaemia levels, lower age, low Hb levels, increased MPV and platelet aggregate flag. Platelet aggregates were more frequent in malaria-infected children (25% vs. 4%, p<0.0001) and associated with thrombocytopaenia rather than malaria status. Conclusion Children infected with Plasmodium falciparum malaria exhibited important changes in some haematological parameters with low platelet count and haemoglobin concentration being the two most important predictors of malaria infection in children in our study area. When used in combination with other clinical and microscopy, these parameters could improve malaria diagnosis in sub-patent cases. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 9 Suppl 3 S4 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Hongo Gordon Gaddy Charla Walsh Douglas Maina Robert N Waitumbi John Otieno Lucas Jones David Ogutu Bernhards R Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria is the commonest cause of childhood morbidity in Western Kenya with varied heamatological consequences. The t study sought to elucidate the haemotological changes in children infected with malaria and their impact on improved diagnosis and therapy of childhood malaria. Methods Haematological parameters in 961 children, including 523 malaria-infected and 438 non-malaria infected, living in Kisumu West District, an area of malaria holoendemic transmission in Western Kenya were evaluated. Results The following parameters were significantly lower in malaria-infected children; platelets, lymphocytes, eosinophils, red blood cell count and haemoglobin (Hb), while absolute monocyte and neutrophil counts, and mean platelet volume (MPV) were higher in comparison to non-malaria infected children. Children with platelet counts of <150,000/uL were 13.8 times (odds ratio) more likely to have malaria. Thrombocytopaenia was present in 49% of malaria-infected children and was associated with high parasitaemia levels, lower age, low Hb levels, increased MPV and platelet aggregate flag. Platelet aggregates were more frequent in malaria-infected children (25% vs. 4%, p<0.0001) and associated with thrombocytopaenia rather than malaria status. Conclusion Children infected with Plasmodium falciparum malaria exhibited important changes in some haematological parameters with low platelet count and haemoglobin concentration being the two most important predictors of malaria infection in children in our study area. When used in combination with other clinical and microscopy, these parameters could improve malaria diagnosis in sub-patent cases. |
format |
Article in Journal/Newspaper |
author |
Hongo Gordon Gaddy Charla Walsh Douglas Maina Robert N Waitumbi John Otieno Lucas Jones David Ogutu Bernhards R |
author_facet |
Hongo Gordon Gaddy Charla Walsh Douglas Maina Robert N Waitumbi John Otieno Lucas Jones David Ogutu Bernhards R |
author_sort |
Hongo Gordon |
title |
Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya |
title_short |
Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya |
title_full |
Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya |
title_fullStr |
Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya |
title_full_unstemmed |
Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya |
title_sort |
impact of plasmodium falciparum infection on haematological parameters in children living in western kenya |
publisher |
BMC |
publishDate |
2010 |
url |
https://doi.org/10.1186/1475-2875-9-S3-S4 https://doaj.org/article/7cb9b70c463e49c0ac6cfcba4dc2e4ca |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 9, Iss Suppl 3, p S4 (2010) |
op_relation |
https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-9-S3-S4 1475-2875 https://doaj.org/article/7cb9b70c463e49c0ac6cfcba4dc2e4ca |
op_doi |
https://doi.org/10.1186/1475-2875-9-S3-S4 |
container_title |
Malaria Journal |
container_volume |
9 |
container_issue |
Suppl 3 |
container_start_page |
S4 |
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1766340590417477632 |