An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster
Summary: BCR/TCR-based adaptive immune systems arise in the jawed vertebrates, and B cell receptors (BCRs) play an important role in the clonal selection of B cells and their differentiation into antibody-secreting plasma cells. The existence of BCR-like molecule and the activation mechanism of the...
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ftdoajarticles:oai:doaj.org/article:7c7a5a85680e4c0fade67f29b86c727e 2023-05-15T15:58:37+02:00 An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster Jiejie Sun Lingling Wang Chuanyan Yang Linsheng Song 2020-02-01T00:00:00Z https://doi.org/10.1016/j.isci.2020.100834 https://doaj.org/article/7c7a5a85680e4c0fade67f29b86c727e EN eng Elsevier http://www.sciencedirect.com/science/article/pii/S2589004220300171 https://doaj.org/toc/2589-0042 2589-0042 doi:10.1016/j.isci.2020.100834 https://doaj.org/article/7c7a5a85680e4c0fade67f29b86c727e iScience, Vol 23, Iss 2, Pp - (2020) Science Q article 2020 ftdoajarticles https://doi.org/10.1016/j.isci.2020.100834 2022-12-31T12:26:52Z Summary: BCR/TCR-based adaptive immune systems arise in the jawed vertebrates, and B cell receptors (BCRs) play an important role in the clonal selection of B cells and their differentiation into antibody-secreting plasma cells. The existence of BCR-like molecule and the activation mechanism of the downstream response are still not clear in invertebrates. In this study, an ancient BCR-like molecule (designated as CgIgR) with an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic tail was identified from the Pacific oyster Crassostrea gigas to investigate its involvement in immune response. CgIgR could bind different bacteria through five extracellular Ig domains and formed dimers. The activated CgIgR recruited CgSyk to promote CgERK phosphorylation. The CgIgR-mediated signaling promoted the production of immunoglobulin domain-containing proteins (CgICP-2 and CgLRRIG-1) through inducing CgH3K4me2. The produced CgICPs eventually facilitated hemocytes to phagocytize and eliminate V. splendidus. This study proposed that there was an ancient BCR-like molecule and BCR-like signaling in molluscs. : Biological Sciences; Immunology; Cell Biology Subject Areas: Biological Sciences, Immunology, Cell Biology Article in Journal/Newspaper Crassostrea gigas Pacific oyster Directory of Open Access Journals: DOAJ Articles Pacific iScience 23 2 100834 |
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Science Q Jiejie Sun Lingling Wang Chuanyan Yang Linsheng Song An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster |
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Summary: BCR/TCR-based adaptive immune systems arise in the jawed vertebrates, and B cell receptors (BCRs) play an important role in the clonal selection of B cells and their differentiation into antibody-secreting plasma cells. The existence of BCR-like molecule and the activation mechanism of the downstream response are still not clear in invertebrates. In this study, an ancient BCR-like molecule (designated as CgIgR) with an immunoreceptor tyrosine-based activation motif (ITAM) in its cytoplasmic tail was identified from the Pacific oyster Crassostrea gigas to investigate its involvement in immune response. CgIgR could bind different bacteria through five extracellular Ig domains and formed dimers. The activated CgIgR recruited CgSyk to promote CgERK phosphorylation. The CgIgR-mediated signaling promoted the production of immunoglobulin domain-containing proteins (CgICP-2 and CgLRRIG-1) through inducing CgH3K4me2. The produced CgICPs eventually facilitated hemocytes to phagocytize and eliminate V. splendidus. This study proposed that there was an ancient BCR-like molecule and BCR-like signaling in molluscs. : Biological Sciences; Immunology; Cell Biology Subject Areas: Biological Sciences, Immunology, Cell Biology |
format |
Article in Journal/Newspaper |
author |
Jiejie Sun Lingling Wang Chuanyan Yang Linsheng Song |
author_facet |
Jiejie Sun Lingling Wang Chuanyan Yang Linsheng Song |
author_sort |
Jiejie Sun |
title |
An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster |
title_short |
An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster |
title_full |
An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster |
title_fullStr |
An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster |
title_full_unstemmed |
An Ancient BCR-like Signaling Promotes ICP Production and Hemocyte Phagocytosis in Oyster |
title_sort |
ancient bcr-like signaling promotes icp production and hemocyte phagocytosis in oyster |
publisher |
Elsevier |
publishDate |
2020 |
url |
https://doi.org/10.1016/j.isci.2020.100834 https://doaj.org/article/7c7a5a85680e4c0fade67f29b86c727e |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_source |
iScience, Vol 23, Iss 2, Pp - (2020) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2589004220300171 https://doaj.org/toc/2589-0042 2589-0042 doi:10.1016/j.isci.2020.100834 https://doaj.org/article/7c7a5a85680e4c0fade67f29b86c727e |
op_doi |
https://doi.org/10.1016/j.isci.2020.100834 |
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iScience |
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23 |
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2 |
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100834 |
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