Public health determinants of child malaria mortality: a surveillance study within Siaya County, Western Kenya
Abstract Background Malaria deaths among children have been declining worldwide during the last two decades. Despite preventive, epidemiologic and therapy-development work, mortality rate decline has stagnated in western Kenya resulting in persistently high child malaria morbidity and mortality. The...
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ftdoajarticles:oai:doaj.org/article:7c727a7ad9e1426588c4fa918b60baa1 2023-05-15T15:18:41+02:00 Public health determinants of child malaria mortality: a surveillance study within Siaya County, Western Kenya Thomas Hollowell Maquins Odhiambo Sewe Joacim Rocklöv David Obor Frank Odhiambo Clas Ahlm 2023-02-01T00:00:00Z https://doi.org/10.1186/s12936-023-04502-9 https://doaj.org/article/7c727a7ad9e1426588c4fa918b60baa1 EN eng BMC https://doi.org/10.1186/s12936-023-04502-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04502-9 1475-2875 https://doaj.org/article/7c727a7ad9e1426588c4fa918b60baa1 Malaria Journal, Vol 22, Iss 1, Pp 1-12 (2023) Malaria Public health Children Epidemiological monitoring Demographic surveillance Child mortality Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2023 ftdoajarticles https://doi.org/10.1186/s12936-023-04502-9 2023-03-26T01:33:52Z Abstract Background Malaria deaths among children have been declining worldwide during the last two decades. Despite preventive, epidemiologic and therapy-development work, mortality rate decline has stagnated in western Kenya resulting in persistently high child malaria morbidity and mortality. The aim of this study was to identify public health determinants influencing the high burden of malaria deaths among children in this region. Methods A total of 221,929 children, 111,488 females and 110,441 males, under the age of 5 years were enrolled in the Kenya Medical Research Institute/Center for Disease Control Health and Demographic Surveillance System (KEMRI/CDC HDSS) study area in Siaya County during the period 2003–2013. Cause of death was determined by use of verbal autopsy. Age-specific mortality rates were computed, and cox proportional hazard regression was used to model time to malaria death controlling for the socio-demographic factors. A variety of demographic, social and epidemiologic factors were examined. Results In total 8,696 (3.9%) children died during the study period. Malaria was the most prevalent cause of death and constituted 33.2% of all causes of death, followed by acute respiratory infections (26.7%) and HIV/AIDS related deaths (18.6%). There was a marked decrease in overall mortality rate from 2003 to 2013, except for a spike in the rates in 2008. The hazard of death differed between age groups with the youngest having the highest hazard of death HR 6.07 (95% CI 5.10–7.22). Overall, the risk attenuated with age and mortality risks were limited beyond 4 years of age. Longer distance to healthcare HR of 1.44 (95% CI 1.29–1.60), l ow maternal education HR 3.91 (95% CI 1.86–8.22), and low socioeconomic status HR 1.44 (95% CI 1.26–1.64) were all significantly associated with increased hazard of malaria death among children. Conclusions While child mortality due to malaria in the study area in Western Kenya, has been decreasing, a final step toward significant risk reduction is yet to be ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 22 1 |
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ftdoajarticles |
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English |
topic |
Malaria Public health Children Epidemiological monitoring Demographic surveillance Child mortality Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Malaria Public health Children Epidemiological monitoring Demographic surveillance Child mortality Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Thomas Hollowell Maquins Odhiambo Sewe Joacim Rocklöv David Obor Frank Odhiambo Clas Ahlm Public health determinants of child malaria mortality: a surveillance study within Siaya County, Western Kenya |
topic_facet |
Malaria Public health Children Epidemiological monitoring Demographic surveillance Child mortality Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria deaths among children have been declining worldwide during the last two decades. Despite preventive, epidemiologic and therapy-development work, mortality rate decline has stagnated in western Kenya resulting in persistently high child malaria morbidity and mortality. The aim of this study was to identify public health determinants influencing the high burden of malaria deaths among children in this region. Methods A total of 221,929 children, 111,488 females and 110,441 males, under the age of 5 years were enrolled in the Kenya Medical Research Institute/Center for Disease Control Health and Demographic Surveillance System (KEMRI/CDC HDSS) study area in Siaya County during the period 2003–2013. Cause of death was determined by use of verbal autopsy. Age-specific mortality rates were computed, and cox proportional hazard regression was used to model time to malaria death controlling for the socio-demographic factors. A variety of demographic, social and epidemiologic factors were examined. Results In total 8,696 (3.9%) children died during the study period. Malaria was the most prevalent cause of death and constituted 33.2% of all causes of death, followed by acute respiratory infections (26.7%) and HIV/AIDS related deaths (18.6%). There was a marked decrease in overall mortality rate from 2003 to 2013, except for a spike in the rates in 2008. The hazard of death differed between age groups with the youngest having the highest hazard of death HR 6.07 (95% CI 5.10–7.22). Overall, the risk attenuated with age and mortality risks were limited beyond 4 years of age. Longer distance to healthcare HR of 1.44 (95% CI 1.29–1.60), l ow maternal education HR 3.91 (95% CI 1.86–8.22), and low socioeconomic status HR 1.44 (95% CI 1.26–1.64) were all significantly associated with increased hazard of malaria death among children. Conclusions While child mortality due to malaria in the study area in Western Kenya, has been decreasing, a final step toward significant risk reduction is yet to be ... |
format |
Article in Journal/Newspaper |
author |
Thomas Hollowell Maquins Odhiambo Sewe Joacim Rocklöv David Obor Frank Odhiambo Clas Ahlm |
author_facet |
Thomas Hollowell Maquins Odhiambo Sewe Joacim Rocklöv David Obor Frank Odhiambo Clas Ahlm |
author_sort |
Thomas Hollowell |
title |
Public health determinants of child malaria mortality: a surveillance study within Siaya County, Western Kenya |
title_short |
Public health determinants of child malaria mortality: a surveillance study within Siaya County, Western Kenya |
title_full |
Public health determinants of child malaria mortality: a surveillance study within Siaya County, Western Kenya |
title_fullStr |
Public health determinants of child malaria mortality: a surveillance study within Siaya County, Western Kenya |
title_full_unstemmed |
Public health determinants of child malaria mortality: a surveillance study within Siaya County, Western Kenya |
title_sort |
public health determinants of child malaria mortality: a surveillance study within siaya county, western kenya |
publisher |
BMC |
publishDate |
2023 |
url |
https://doi.org/10.1186/s12936-023-04502-9 https://doaj.org/article/7c727a7ad9e1426588c4fa918b60baa1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 22, Iss 1, Pp 1-12 (2023) |
op_relation |
https://doi.org/10.1186/s12936-023-04502-9 https://doaj.org/toc/1475-2875 doi:10.1186/s12936-023-04502-9 1475-2875 https://doaj.org/article/7c727a7ad9e1426588c4fa918b60baa1 |
op_doi |
https://doi.org/10.1186/s12936-023-04502-9 |
container_title |
Malaria Journal |
container_volume |
22 |
container_issue |
1 |
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1766348867849158656 |