Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling
Recently, microorganisms and their metabolites in the Antarctic marine environment have attracted attention as useful sources for novel therapeutics, including anticancer drugs. Here, we investigated the effects of citromycin, isolated from the Antarctic marine-derived fungus, Sporothrix sp., on hum...
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ftdoajarticles:oai:doaj.org/article:7c3c3b6183604731bbaa59330461f1b1 2023-05-15T14:02:56+02:00 Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling He Yun Choi Ji-Hye Ahn Haeun Kwon Joung Han Yim Dongho Lee Jung-Hye Choi 2022-04-01T00:00:00Z https://doi.org/10.3390/md20050275 https://doaj.org/article/7c3c3b6183604731bbaa59330461f1b1 EN eng MDPI AG https://www.mdpi.com/1660-3397/20/5/275 https://doaj.org/toc/1660-3397 doi:10.3390/md20050275 1660-3397 https://doaj.org/article/7c3c3b6183604731bbaa59330461f1b1 Marine Drugs, Vol 20, Iss 275, p 275 (2022) citromycin Sporothrix sp ovarian cancer invasion MMP2 and MMP9 ERK1/2 pathway Biology (General) QH301-705.5 article 2022 ftdoajarticles https://doi.org/10.3390/md20050275 2022-12-30T20:01:01Z Recently, microorganisms and their metabolites in the Antarctic marine environment have attracted attention as useful sources for novel therapeutics, including anticancer drugs. Here, we investigated the effects of citromycin, isolated from the Antarctic marine-derived fungus, Sporothrix sp., on human ovarian cancer cells. Citromycin inhibited the migration and invasion of human ovarian cancer SKOV3 and A2780 cells, but had no cytotoxic activity against them. Additionally, it inhibited the expression of epithelial–mesenchymal transition (EMT) markers and the activation of matrix metalloproteinase (MMP)-2 and MMP9. Moreover, extracellular signal-regulated kinase (ERK)-1/2 signaling was inhibited after citromycin treatment, and the ectopic expression of ERK negated the anti-invasive activity of citromycin. Our findings suggest that citromycin inhibits the migration and invasion of human ovarian cancer cells by downregulating the expression levels of EMT markers and MMP-2/9 via inhibition of the ERK1/2 pathway. Article in Journal/Newspaper Antarc* Antarctic Directory of Open Access Journals: DOAJ Articles Antarctic The Antarctic Marine Drugs 20 5 275 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
citromycin Sporothrix sp ovarian cancer invasion MMP2 and MMP9 ERK1/2 pathway Biology (General) QH301-705.5 |
spellingShingle |
citromycin Sporothrix sp ovarian cancer invasion MMP2 and MMP9 ERK1/2 pathway Biology (General) QH301-705.5 He Yun Choi Ji-Hye Ahn Haeun Kwon Joung Han Yim Dongho Lee Jung-Hye Choi Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling |
topic_facet |
citromycin Sporothrix sp ovarian cancer invasion MMP2 and MMP9 ERK1/2 pathway Biology (General) QH301-705.5 |
description |
Recently, microorganisms and their metabolites in the Antarctic marine environment have attracted attention as useful sources for novel therapeutics, including anticancer drugs. Here, we investigated the effects of citromycin, isolated from the Antarctic marine-derived fungus, Sporothrix sp., on human ovarian cancer cells. Citromycin inhibited the migration and invasion of human ovarian cancer SKOV3 and A2780 cells, but had no cytotoxic activity against them. Additionally, it inhibited the expression of epithelial–mesenchymal transition (EMT) markers and the activation of matrix metalloproteinase (MMP)-2 and MMP9. Moreover, extracellular signal-regulated kinase (ERK)-1/2 signaling was inhibited after citromycin treatment, and the ectopic expression of ERK negated the anti-invasive activity of citromycin. Our findings suggest that citromycin inhibits the migration and invasion of human ovarian cancer cells by downregulating the expression levels of EMT markers and MMP-2/9 via inhibition of the ERK1/2 pathway. |
format |
Article in Journal/Newspaper |
author |
He Yun Choi Ji-Hye Ahn Haeun Kwon Joung Han Yim Dongho Lee Jung-Hye Choi |
author_facet |
He Yun Choi Ji-Hye Ahn Haeun Kwon Joung Han Yim Dongho Lee Jung-Hye Choi |
author_sort |
He Yun Choi |
title |
Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling |
title_short |
Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling |
title_full |
Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling |
title_fullStr |
Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling |
title_full_unstemmed |
Citromycin Isolated from the Antarctic Marine-Derived Fungi, Sporothrix sp., Inhibits Ovarian Cancer Cell Invasion via Suppression of ERK Signaling |
title_sort |
citromycin isolated from the antarctic marine-derived fungi, sporothrix sp., inhibits ovarian cancer cell invasion via suppression of erk signaling |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/md20050275 https://doaj.org/article/7c3c3b6183604731bbaa59330461f1b1 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_source |
Marine Drugs, Vol 20, Iss 275, p 275 (2022) |
op_relation |
https://www.mdpi.com/1660-3397/20/5/275 https://doaj.org/toc/1660-3397 doi:10.3390/md20050275 1660-3397 https://doaj.org/article/7c3c3b6183604731bbaa59330461f1b1 |
op_doi |
https://doi.org/10.3390/md20050275 |
container_title |
Marine Drugs |
container_volume |
20 |
container_issue |
5 |
container_start_page |
275 |
_version_ |
1766273390829633536 |