Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity
Abstract Background Malaria in pregnancy is characterised by the sequestration of Plasmodium falciparum -infected erythrocytes in placental intervillous spaces. Placental parasites express a specific phenotype, which allows them to cytoadhere to chondroitin sulfate A expressed by syncytiotrophoblast...
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ftdoajarticles:oai:doaj.org/article:7bf3e9fdf54546f3ac2b0da56a44084a 2023-05-15T15:13:32+02:00 Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity Cot Michel Moussa Marlène Shaw Ian K Maubert Bertrand Tami Germaine Fievet Nadine Holder Anthony A Chaouat Gérard Deloron Philippe 2002-11-01T00:00:00Z https://doi.org/10.1186/1475-2875-1-16 https://doaj.org/article/7bf3e9fdf54546f3ac2b0da56a44084a EN eng BMC http://www.malariajournal.com/content/1/1/16 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-1-16 1475-2875 https://doaj.org/article/7bf3e9fdf54546f3ac2b0da56a44084a Malaria Journal, Vol 1, Iss 1, p 16 (2002) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2002 ftdoajarticles https://doi.org/10.1186/1475-2875-1-16 2022-12-30T22:15:22Z Abstract Background Malaria in pregnancy is characterised by the sequestration of Plasmodium falciparum -infected erythrocytes in placental intervillous spaces. Placental parasites express a specific phenotype, which allows them to cytoadhere to chondroitin sulfate A expressed by syncytiotrophoblasts. Malaria infection during pregnancy allows the acquisition of antibodies against placental parasites, these antibodies are thought to be involved in protection during subsequent pregnancies. Methods To investigate the development of a cellular response to placental parasites during pregnancy, peripheral blood mononuclear cells were collected from women at the time of their confinement. The study was performed in Cameroon where malaria transmission is perennial. In vitro cell proliferation and cytokine production were measured in response to non-malarial activators (concanavalin A and PPD), a recombinant protein from P. falciparum MSP-1, and erythrocytes infected by two P. falciparum lines, RP5 and W2. Like placental parasites, the RP5 line, but not W2, adheres to chondroitin sulfate A and to syncytiotrophoblasts. Results The proliferative response to all antigens was lower for cells obtained at delivery than 3 months later. Most interestingly, the cellular response to the RP5 line of P. falciparum was closely related to parity. The prevalence rate and the levels of response gradually increased with the number of previous pregnancies. No such relationship was observed with W2 line, or MSP-1 antigen. Conclusions This suggests the occurrence of an immune response more specific for the RP5 line in women having had multiple pregnancies, and who are likely to develop immunity to pregnancy-associated parasites. Both humoral and cellular mechanisms may account for the lower susceptibility of multigravidae to malaria. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 1 1 16 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Cot Michel Moussa Marlène Shaw Ian K Maubert Bertrand Tami Germaine Fievet Nadine Holder Anthony A Chaouat Gérard Deloron Philippe Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Malaria in pregnancy is characterised by the sequestration of Plasmodium falciparum -infected erythrocytes in placental intervillous spaces. Placental parasites express a specific phenotype, which allows them to cytoadhere to chondroitin sulfate A expressed by syncytiotrophoblasts. Malaria infection during pregnancy allows the acquisition of antibodies against placental parasites, these antibodies are thought to be involved in protection during subsequent pregnancies. Methods To investigate the development of a cellular response to placental parasites during pregnancy, peripheral blood mononuclear cells were collected from women at the time of their confinement. The study was performed in Cameroon where malaria transmission is perennial. In vitro cell proliferation and cytokine production were measured in response to non-malarial activators (concanavalin A and PPD), a recombinant protein from P. falciparum MSP-1, and erythrocytes infected by two P. falciparum lines, RP5 and W2. Like placental parasites, the RP5 line, but not W2, adheres to chondroitin sulfate A and to syncytiotrophoblasts. Results The proliferative response to all antigens was lower for cells obtained at delivery than 3 months later. Most interestingly, the cellular response to the RP5 line of P. falciparum was closely related to parity. The prevalence rate and the levels of response gradually increased with the number of previous pregnancies. No such relationship was observed with W2 line, or MSP-1 antigen. Conclusions This suggests the occurrence of an immune response more specific for the RP5 line in women having had multiple pregnancies, and who are likely to develop immunity to pregnancy-associated parasites. Both humoral and cellular mechanisms may account for the lower susceptibility of multigravidae to malaria. |
format |
Article in Journal/Newspaper |
author |
Cot Michel Moussa Marlène Shaw Ian K Maubert Bertrand Tami Germaine Fievet Nadine Holder Anthony A Chaouat Gérard Deloron Philippe |
author_facet |
Cot Michel Moussa Marlène Shaw Ian K Maubert Bertrand Tami Germaine Fievet Nadine Holder Anthony A Chaouat Gérard Deloron Philippe |
author_sort |
Cot Michel |
title |
Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity |
title_short |
Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity |
title_full |
Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity |
title_fullStr |
Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity |
title_full_unstemmed |
Cellular immune response to Plasmodium falciparum after pregnancy is related to previous placental infection and parity |
title_sort |
cellular immune response to plasmodium falciparum after pregnancy is related to previous placental infection and parity |
publisher |
BMC |
publishDate |
2002 |
url |
https://doi.org/10.1186/1475-2875-1-16 https://doaj.org/article/7bf3e9fdf54546f3ac2b0da56a44084a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 1, Iss 1, p 16 (2002) |
op_relation |
http://www.malariajournal.com/content/1/1/16 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-1-16 1475-2875 https://doaj.org/article/7bf3e9fdf54546f3ac2b0da56a44084a |
op_doi |
https://doi.org/10.1186/1475-2875-1-16 |
container_title |
Malaria Journal |
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1 |
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1 |
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16 |
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