Childhood pneumococcal disease burden in Argentina Carga por enfermedad neumocócica en niños de Argentina
OBJECTIVES: To understand the disease burden of pneumococcal disease (PD), a major cause of childhood morbidity and mortality in Argentina, and to draw a baseline against which the need for and effectiveness of vaccination with pneumococcal conjugate vaccines might be measured. METHODS: A Markov mod...
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Pan American Health Organization
2009
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ftdoajarticles:oai:doaj.org/article:7be5533fddc24cd0a5247dc848244160 2023-05-15T15:18:27+02:00 Childhood pneumococcal disease burden in Argentina Carga por enfermedad neumocócica en niños de Argentina Federico Ariel Augustovski Sebastián García Martí Andrés Pichon-Riviere Roberto Debbag 2009-05-01T00:00:00Z https://doaj.org/article/7be5533fddc24cd0a5247dc848244160 EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892009000500007 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/7be5533fddc24cd0a5247dc848244160 Revista Panamericana de Salud Pública, Vol 25, Iss 5, Pp 423-430 (2009) Meningitis neumocócica infecciones neumocócicas vacunas neumocócicas análisis costo-beneficio Argentina Meningitis pneumococcal pneumococcal infections pneumococcal vaccines cost-benefit analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles 2022-12-31T15:23:17Z OBJECTIVES: To understand the disease burden of pneumococcal disease (PD), a major cause of childhood morbidity and mortality in Argentina, and to draw a baseline against which the need for and effectiveness of vaccination with pneumococcal conjugate vaccines might be measured. METHODS: A Markov model was constructed to estimate incidence and mortality rates of PD-meningitis (MEN), bacteremia/septicemia (BACT), pneumonia (PNEU), acute otitis media (AOM)-among a hypothetical, birth cohort of 750 000 Argentine infants born in 2006-2015. A systematic review of the literature was performed to select and incorporate input parameters. Life years and costs in 2006 US$ were expressed as both undiscounted and discounted. RESULTS: The number of PD episodes estimated to occur over a 10-year period in the hypothetical birth cohort were: MEN, 225; BACT, 2 841; PNEU, 2 628; and AOM, 2 066 719. Chronic sequelae of MEN could be expected to cause neurological damage in 43 children and severe hearing issues in 28. Results indicate that there would be 78 PD-related deaths in the cohort (29% due to MEN; 54%, BACT; and 17%, PNEU). The undiscounted life-expectancy for individuals in the birth cohort was estimated to be 72.4 years (29.0 years discounted). Mean, undiscounted, lifetime costs attributed to PD for each child of the cohort totaled US$ 167 (US$ 151 discounted), imposing a total, cohort cost-burden of more than US$ 126 million (US$ 113 million discounted). CONCLUSIONS: The study shows that PD imposes a significant health and economic burden on the Argentine population. This information is essential for assessing the potential health and economic impact of introducing pneumococcal conjugate vaccine into the national immunization schedule. OBJETIVOS: Analizar la carga que provoca la enfermedad neumocócica (EN), una importante causa de morbimortalidad infantil en Argentina y establecer una línea de base a partir de la cual se pueda medir la necesidad y la eficacia del uso de vacunas antineumocócicas conjugadas. MÉTODOS: Se ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Argentina Argentine |
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Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Meningitis neumocócica infecciones neumocócicas vacunas neumocócicas análisis costo-beneficio Argentina Meningitis pneumococcal pneumococcal infections pneumococcal vaccines cost-benefit analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Meningitis neumocócica infecciones neumocócicas vacunas neumocócicas análisis costo-beneficio Argentina Meningitis pneumococcal pneumococcal infections pneumococcal vaccines cost-benefit analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Federico Ariel Augustovski Sebastián García Martí Andrés Pichon-Riviere Roberto Debbag Childhood pneumococcal disease burden in Argentina Carga por enfermedad neumocócica en niños de Argentina |
topic_facet |
Meningitis neumocócica infecciones neumocócicas vacunas neumocócicas análisis costo-beneficio Argentina Meningitis pneumococcal pneumococcal infections pneumococcal vaccines cost-benefit analysis Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVES: To understand the disease burden of pneumococcal disease (PD), a major cause of childhood morbidity and mortality in Argentina, and to draw a baseline against which the need for and effectiveness of vaccination with pneumococcal conjugate vaccines might be measured. METHODS: A Markov model was constructed to estimate incidence and mortality rates of PD-meningitis (MEN), bacteremia/septicemia (BACT), pneumonia (PNEU), acute otitis media (AOM)-among a hypothetical, birth cohort of 750 000 Argentine infants born in 2006-2015. A systematic review of the literature was performed to select and incorporate input parameters. Life years and costs in 2006 US$ were expressed as both undiscounted and discounted. RESULTS: The number of PD episodes estimated to occur over a 10-year period in the hypothetical birth cohort were: MEN, 225; BACT, 2 841; PNEU, 2 628; and AOM, 2 066 719. Chronic sequelae of MEN could be expected to cause neurological damage in 43 children and severe hearing issues in 28. Results indicate that there would be 78 PD-related deaths in the cohort (29% due to MEN; 54%, BACT; and 17%, PNEU). The undiscounted life-expectancy for individuals in the birth cohort was estimated to be 72.4 years (29.0 years discounted). Mean, undiscounted, lifetime costs attributed to PD for each child of the cohort totaled US$ 167 (US$ 151 discounted), imposing a total, cohort cost-burden of more than US$ 126 million (US$ 113 million discounted). CONCLUSIONS: The study shows that PD imposes a significant health and economic burden on the Argentine population. This information is essential for assessing the potential health and economic impact of introducing pneumococcal conjugate vaccine into the national immunization schedule. OBJETIVOS: Analizar la carga que provoca la enfermedad neumocócica (EN), una importante causa de morbimortalidad infantil en Argentina y establecer una línea de base a partir de la cual se pueda medir la necesidad y la eficacia del uso de vacunas antineumocócicas conjugadas. MÉTODOS: Se ... |
format |
Article in Journal/Newspaper |
author |
Federico Ariel Augustovski Sebastián García Martí Andrés Pichon-Riviere Roberto Debbag |
author_facet |
Federico Ariel Augustovski Sebastián García Martí Andrés Pichon-Riviere Roberto Debbag |
author_sort |
Federico Ariel Augustovski |
title |
Childhood pneumococcal disease burden in Argentina Carga por enfermedad neumocócica en niños de Argentina |
title_short |
Childhood pneumococcal disease burden in Argentina Carga por enfermedad neumocócica en niños de Argentina |
title_full |
Childhood pneumococcal disease burden in Argentina Carga por enfermedad neumocócica en niños de Argentina |
title_fullStr |
Childhood pneumococcal disease burden in Argentina Carga por enfermedad neumocócica en niños de Argentina |
title_full_unstemmed |
Childhood pneumococcal disease burden in Argentina Carga por enfermedad neumocócica en niños de Argentina |
title_sort |
childhood pneumococcal disease burden in argentina carga por enfermedad neumocócica en niños de argentina |
publisher |
Pan American Health Organization |
publishDate |
2009 |
url |
https://doaj.org/article/7be5533fddc24cd0a5247dc848244160 |
geographic |
Arctic Argentina Argentine |
geographic_facet |
Arctic Argentina Argentine |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 25, Iss 5, Pp 423-430 (2009) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892009000500007 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/7be5533fddc24cd0a5247dc848244160 |
_version_ |
1766348653355597824 |