Effectiveness of fluralaner treatment regimens for the control of canine Chagas disease: A mathematical modeling study.
Background Canine Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and transmitted by insect triatomine vectors known as kissing bugs. The agent can cause cardiac damage and long-term heart disease and death in humans, dogs, and other mammals. In laboratory settings, treatment of...
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ftdoajarticles:oai:doaj.org/article:7bd62ec9c8e34631a601476d65f16a89 2023-05-15T15:15:08+02:00 Effectiveness of fluralaner treatment regimens for the control of canine Chagas disease: A mathematical modeling study. Edem Fiatsonu Rachel E Busselman Gabriel L Hamer Sarah A Hamer Martial L Ndeffo-Mbah 2023-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0011084 https://doaj.org/article/7bd62ec9c8e34631a601476d65f16a89 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0011084 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011084 https://doaj.org/article/7bd62ec9c8e34631a601476d65f16a89 PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0011084 (2023) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2023 ftdoajarticles https://doi.org/10.1371/journal.pntd.0011084 2023-03-05T01:33:15Z Background Canine Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and transmitted by insect triatomine vectors known as kissing bugs. The agent can cause cardiac damage and long-term heart disease and death in humans, dogs, and other mammals. In laboratory settings, treatment of dogs with systemic insecticides has been shown to be highly efficacious at killing triatomines that feed on treated dogs. Method We developed compartmental vector-host models of T. cruzi transmission between the triatomine and dog population accounting for the impact of seasonality and triatomine migration on disease transmission dynamics. We considered a single vector-host model without seasonality, and model with seasonality, and a spatially coupled model. We used the models to evaluate the effectiveness of the insecticide fluralaner with different durations of treatment regimens for reducing T. cruzi infection in different transmission settings. Results In low and medium transmission settings, our model showed a marginal difference between the 3-month and 6-month regimens for reducing T. cruzi infection among dogs. The difference increases in the presence of seasonality and triatomine migration from a sylvatic transmission setting. In high transmission settings, the 3-month regimen was substantially more effective in reducing T. cruzi infections in dogs than the other regimens. Our model showed that increased migration rate reduces fluralaner effectiveness in all treatment regimens, but the relative reduction in effectiveness is minimal during the first years of treatment. However, if an additional 10% or more of triatomines killed by dog treatment were eaten by dogs, treatment could increase T. cruzi infections in the dog population at least during the first year of treatment. Conclusion Our analysis shows that treating all peridomestic dogs every three to six months for at least five years could be an effective measure to reduce T. cruzi infections in dogs and triatomines in peridomestic transmission settings. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 17 1 e0011084 |
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Directory of Open Access Journals: DOAJ Articles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Edem Fiatsonu Rachel E Busselman Gabriel L Hamer Sarah A Hamer Martial L Ndeffo-Mbah Effectiveness of fluralaner treatment regimens for the control of canine Chagas disease: A mathematical modeling study. |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Canine Chagas disease is caused by the protozoan parasite Trypanosoma cruzi and transmitted by insect triatomine vectors known as kissing bugs. The agent can cause cardiac damage and long-term heart disease and death in humans, dogs, and other mammals. In laboratory settings, treatment of dogs with systemic insecticides has been shown to be highly efficacious at killing triatomines that feed on treated dogs. Method We developed compartmental vector-host models of T. cruzi transmission between the triatomine and dog population accounting for the impact of seasonality and triatomine migration on disease transmission dynamics. We considered a single vector-host model without seasonality, and model with seasonality, and a spatially coupled model. We used the models to evaluate the effectiveness of the insecticide fluralaner with different durations of treatment regimens for reducing T. cruzi infection in different transmission settings. Results In low and medium transmission settings, our model showed a marginal difference between the 3-month and 6-month regimens for reducing T. cruzi infection among dogs. The difference increases in the presence of seasonality and triatomine migration from a sylvatic transmission setting. In high transmission settings, the 3-month regimen was substantially more effective in reducing T. cruzi infections in dogs than the other regimens. Our model showed that increased migration rate reduces fluralaner effectiveness in all treatment regimens, but the relative reduction in effectiveness is minimal during the first years of treatment. However, if an additional 10% or more of triatomines killed by dog treatment were eaten by dogs, treatment could increase T. cruzi infections in the dog population at least during the first year of treatment. Conclusion Our analysis shows that treating all peridomestic dogs every three to six months for at least five years could be an effective measure to reduce T. cruzi infections in dogs and triatomines in peridomestic transmission settings. ... |
format |
Article in Journal/Newspaper |
author |
Edem Fiatsonu Rachel E Busselman Gabriel L Hamer Sarah A Hamer Martial L Ndeffo-Mbah |
author_facet |
Edem Fiatsonu Rachel E Busselman Gabriel L Hamer Sarah A Hamer Martial L Ndeffo-Mbah |
author_sort |
Edem Fiatsonu |
title |
Effectiveness of fluralaner treatment regimens for the control of canine Chagas disease: A mathematical modeling study. |
title_short |
Effectiveness of fluralaner treatment regimens for the control of canine Chagas disease: A mathematical modeling study. |
title_full |
Effectiveness of fluralaner treatment regimens for the control of canine Chagas disease: A mathematical modeling study. |
title_fullStr |
Effectiveness of fluralaner treatment regimens for the control of canine Chagas disease: A mathematical modeling study. |
title_full_unstemmed |
Effectiveness of fluralaner treatment regimens for the control of canine Chagas disease: A mathematical modeling study. |
title_sort |
effectiveness of fluralaner treatment regimens for the control of canine chagas disease: a mathematical modeling study. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2023 |
url |
https://doi.org/10.1371/journal.pntd.0011084 https://doaj.org/article/7bd62ec9c8e34631a601476d65f16a89 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 17, Iss 1, p e0011084 (2023) |
op_relation |
https://doi.org/10.1371/journal.pntd.0011084 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0011084 https://doaj.org/article/7bd62ec9c8e34631a601476d65f16a89 |
op_doi |
https://doi.org/10.1371/journal.pntd.0011084 |
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PLOS Neglected Tropical Diseases |
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17 |
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1 |
container_start_page |
e0011084 |
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1766345515669127168 |