Towards elimination of visceral leishmaniasis in the Indian subcontinent-Translating research to practice to public health.
The decade following the Regional Strategic Framework for Visceral Leishmaniasis (VL) elimination in 2005 has shown compelling progress in the reduction of VL burden in the Indian subcontinent. The Special Programme for Research and Training in Tropical Diseases (TDR), hosted by the World Health Org...
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ftdoajarticles:oai:doaj.org/article:7bc6a4a54e1047379c34e241c74784ce 2023-05-15T15:13:47+02:00 Towards elimination of visceral leishmaniasis in the Indian subcontinent-Translating research to practice to public health. Siddhivinayak Hirve Axel Kroeger Greg Matlashewski Dinesh Mondal Megha Raj Banjara Pradeep Das Ahmed Be-Nazir Byron Arana Piero Olliaro 2017-10-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005889 https://doaj.org/article/7bc6a4a54e1047379c34e241c74784ce EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5638223?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005889 https://doaj.org/article/7bc6a4a54e1047379c34e241c74784ce PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0005889 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005889 2022-12-31T08:44:43Z The decade following the Regional Strategic Framework for Visceral Leishmaniasis (VL) elimination in 2005 has shown compelling progress in the reduction of VL burden in the Indian subcontinent. The Special Programme for Research and Training in Tropical Diseases (TDR), hosted by the World Health Organization (WHO) and other stakeholders, has coordinated and financed research for the development of new innovative tools and strategies to support the regional VL elimination initiative. This paper describes the process of the TDR's engagement and contribution to this initiative.Multiple databases were searched to identify 152 scientific papers and reports with WHO funding or authorship affiliation around the following 3 framework strategies: detection of new cases, morbidity reduction, and prevention of infection. TDR has played a critical role in the evaluation and subsequent use of the 39-aminoacid-recombinant kinesin antigen (rK39) rapid diagnostic test (RDT) as a confirmatory test for VL in the national program. TDR has supported the clinical research and development of miltefosine and single-dose liposomal amphotericin B as a first-line treatment against VL. TDR has engaged with in-country researchers, national programme managers, and partners to generate evidence-based interventions for early detection and treatment of VL patients. TDR evaluated the quality, community acceptance, and cost effectiveness of indoor residual spraying, insecticide-treated bed nets, insecticide-impregnated durable wall linings, insecticidal paint, and environmental management as tools for integrated vector management in reducing sandfly density.TDR's engagement with country policy makers, scientists, and clinicians in the development of effective diagnosis, treatment, case detection, and vector control represents an important example of TDR's stewardship toward the elimination of VL in the Indian subcontinent. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Indian PLOS Neglected Tropical Diseases 11 10 e0005889 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Siddhivinayak Hirve Axel Kroeger Greg Matlashewski Dinesh Mondal Megha Raj Banjara Pradeep Das Ahmed Be-Nazir Byron Arana Piero Olliaro Towards elimination of visceral leishmaniasis in the Indian subcontinent-Translating research to practice to public health. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The decade following the Regional Strategic Framework for Visceral Leishmaniasis (VL) elimination in 2005 has shown compelling progress in the reduction of VL burden in the Indian subcontinent. The Special Programme for Research and Training in Tropical Diseases (TDR), hosted by the World Health Organization (WHO) and other stakeholders, has coordinated and financed research for the development of new innovative tools and strategies to support the regional VL elimination initiative. This paper describes the process of the TDR's engagement and contribution to this initiative.Multiple databases were searched to identify 152 scientific papers and reports with WHO funding or authorship affiliation around the following 3 framework strategies: detection of new cases, morbidity reduction, and prevention of infection. TDR has played a critical role in the evaluation and subsequent use of the 39-aminoacid-recombinant kinesin antigen (rK39) rapid diagnostic test (RDT) as a confirmatory test for VL in the national program. TDR has supported the clinical research and development of miltefosine and single-dose liposomal amphotericin B as a first-line treatment against VL. TDR has engaged with in-country researchers, national programme managers, and partners to generate evidence-based interventions for early detection and treatment of VL patients. TDR evaluated the quality, community acceptance, and cost effectiveness of indoor residual spraying, insecticide-treated bed nets, insecticide-impregnated durable wall linings, insecticidal paint, and environmental management as tools for integrated vector management in reducing sandfly density.TDR's engagement with country policy makers, scientists, and clinicians in the development of effective diagnosis, treatment, case detection, and vector control represents an important example of TDR's stewardship toward the elimination of VL in the Indian subcontinent. |
format |
Article in Journal/Newspaper |
author |
Siddhivinayak Hirve Axel Kroeger Greg Matlashewski Dinesh Mondal Megha Raj Banjara Pradeep Das Ahmed Be-Nazir Byron Arana Piero Olliaro |
author_facet |
Siddhivinayak Hirve Axel Kroeger Greg Matlashewski Dinesh Mondal Megha Raj Banjara Pradeep Das Ahmed Be-Nazir Byron Arana Piero Olliaro |
author_sort |
Siddhivinayak Hirve |
title |
Towards elimination of visceral leishmaniasis in the Indian subcontinent-Translating research to practice to public health. |
title_short |
Towards elimination of visceral leishmaniasis in the Indian subcontinent-Translating research to practice to public health. |
title_full |
Towards elimination of visceral leishmaniasis in the Indian subcontinent-Translating research to practice to public health. |
title_fullStr |
Towards elimination of visceral leishmaniasis in the Indian subcontinent-Translating research to practice to public health. |
title_full_unstemmed |
Towards elimination of visceral leishmaniasis in the Indian subcontinent-Translating research to practice to public health. |
title_sort |
towards elimination of visceral leishmaniasis in the indian subcontinent-translating research to practice to public health. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005889 https://doaj.org/article/7bc6a4a54e1047379c34e241c74784ce |
geographic |
Arctic Indian |
geographic_facet |
Arctic Indian |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 10, p e0005889 (2017) |
op_relation |
http://europepmc.org/articles/PMC5638223?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005889 https://doaj.org/article/7bc6a4a54e1047379c34e241c74784ce |
op_doi |
https://doi.org/10.1371/journal.pntd.0005889 |
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PLOS Neglected Tropical Diseases |
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11 |
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10 |
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e0005889 |
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