Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice Neumonía eosinofílica inducida por aerosol de aceite diésel y piretroide en ratones
OBJECTIVE: To confirm the episode of eosinophilic pneumonitis that occurred in March 2001 in Manaus, Amazon, northern Brazil, as secondary to home aerosolization with 2% cypermethrin diluted in diesel compared with the more conventional 1% cypermethrin and soybean solution used in prophylaxis of den...
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ftdoajarticles:oai:doaj.org/article:7b9470bec8644ab08d8384f948d0b5fc 2023-05-15T15:18:26+02:00 Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice Neumonía eosinofílica inducida por aerosol de aceite diésel y piretroide en ratones Maria Lúcia B. Garcia Ubiratan P. Santos Adenir Perini Milena M. P. Acencio Fernanda D. T. Q. S. Lopes Heloisa M. S. Bueno Paulo H. N. Saldiva Milton A. Martins 2009-06-01T00:00:00Z https://doaj.org/article/7b9470bec8644ab08d8384f948d0b5fc EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892009000600008 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/7b9470bec8644ab08d8384f948d0b5fc Revista Panamericana de Salud Pública, Vol 25, Iss 6, Pp 518-523 (2009) Insecticidas dengue diesel neutrófilos neumonía eosinofílica Brasil Insecticide eosinophilic pneumonia Brazil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2009 ftdoajarticles 2022-12-31T14:06:35Z OBJECTIVE: To confirm the episode of eosinophilic pneumonitis that occurred in March 2001 in Manaus, Amazon, northern Brazil, as secondary to home aerosolization with 2% cypermethrin diluted in diesel compared with the more conventional 1% cypermethrin and soybean solution used in prophylaxis of dengue. METHODS: Four groups of Swiss mice were kept in polycarbonate cages aerosolized with one of the following solutions: diesel, diesel and cypermethrin, soy oil and cypermethrin, and saline. Three and 6 days after exposure, resistance and compliance of the respiratory system and white cell kinetics in peripheral blood and lung tissue were analyzed. RESULTS: The group exposed to diesel and cypermethrin showed higher respiratory system resistance (p < 0.001), lower compliance (p = 0.03), and increased eosinophils in blood (p = 0.03) and lung tissue (p = 0.005) compared with the other groups. There was an increase of neutrophils in the blood of all experimental groups on the third day after exposure (p < 0.001). CONCLUSIONS: We concluded that diesel associated with cypermethrin induced lung hyperresponsiveness in this experimental model and was associated with increased polymorphonuclear cells (eosinophils and neutrophils) in blood and lungs. This effect is strongest on the third day after exposure. These results are similar to the episode that occurred in Manaus in 2001 and suggest that diesel plus cypermethrin home aerosolization for arbovirosis prophylaxis should be revised. OBJETIVO: Confirmar el episodio de neumonía eosinofílica ocurrido en marzo de 2001 en Manaus, Amazonas, en el norte de Brasil, secundario al uso de aerosol de cipermetrina diluida al 2% en aceite diésel en las viviendas en comparación con la profilaxis más convencional contra el dengue, basada en cipermetrina al 1% con aceite de soya. MÉTODOS: Se mantuvieron cuatro grupos de ratones suizos en jaulas de policarbonato y se aplicó aerosol con una de las siguientes soluciones: aceite diésel, aceite diésel y cipermetrina, aceite de soya y ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic |
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Directory of Open Access Journals: DOAJ Articles |
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English Spanish Portuguese |
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Insecticidas dengue diesel neutrófilos neumonía eosinofílica Brasil Insecticide eosinophilic pneumonia Brazil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Insecticidas dengue diesel neutrófilos neumonía eosinofílica Brasil Insecticide eosinophilic pneumonia Brazil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Maria Lúcia B. Garcia Ubiratan P. Santos Adenir Perini Milena M. P. Acencio Fernanda D. T. Q. S. Lopes Heloisa M. S. Bueno Paulo H. N. Saldiva Milton A. Martins Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice Neumonía eosinofílica inducida por aerosol de aceite diésel y piretroide en ratones |
topic_facet |
Insecticidas dengue diesel neutrófilos neumonía eosinofílica Brasil Insecticide eosinophilic pneumonia Brazil Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVE: To confirm the episode of eosinophilic pneumonitis that occurred in March 2001 in Manaus, Amazon, northern Brazil, as secondary to home aerosolization with 2% cypermethrin diluted in diesel compared with the more conventional 1% cypermethrin and soybean solution used in prophylaxis of dengue. METHODS: Four groups of Swiss mice were kept in polycarbonate cages aerosolized with one of the following solutions: diesel, diesel and cypermethrin, soy oil and cypermethrin, and saline. Three and 6 days after exposure, resistance and compliance of the respiratory system and white cell kinetics in peripheral blood and lung tissue were analyzed. RESULTS: The group exposed to diesel and cypermethrin showed higher respiratory system resistance (p < 0.001), lower compliance (p = 0.03), and increased eosinophils in blood (p = 0.03) and lung tissue (p = 0.005) compared with the other groups. There was an increase of neutrophils in the blood of all experimental groups on the third day after exposure (p < 0.001). CONCLUSIONS: We concluded that diesel associated with cypermethrin induced lung hyperresponsiveness in this experimental model and was associated with increased polymorphonuclear cells (eosinophils and neutrophils) in blood and lungs. This effect is strongest on the third day after exposure. These results are similar to the episode that occurred in Manaus in 2001 and suggest that diesel plus cypermethrin home aerosolization for arbovirosis prophylaxis should be revised. OBJETIVO: Confirmar el episodio de neumonía eosinofílica ocurrido en marzo de 2001 en Manaus, Amazonas, en el norte de Brasil, secundario al uso de aerosol de cipermetrina diluida al 2% en aceite diésel en las viviendas en comparación con la profilaxis más convencional contra el dengue, basada en cipermetrina al 1% con aceite de soya. MÉTODOS: Se mantuvieron cuatro grupos de ratones suizos en jaulas de policarbonato y se aplicó aerosol con una de las siguientes soluciones: aceite diésel, aceite diésel y cipermetrina, aceite de soya y ... |
format |
Article in Journal/Newspaper |
author |
Maria Lúcia B. Garcia Ubiratan P. Santos Adenir Perini Milena M. P. Acencio Fernanda D. T. Q. S. Lopes Heloisa M. S. Bueno Paulo H. N. Saldiva Milton A. Martins |
author_facet |
Maria Lúcia B. Garcia Ubiratan P. Santos Adenir Perini Milena M. P. Acencio Fernanda D. T. Q. S. Lopes Heloisa M. S. Bueno Paulo H. N. Saldiva Milton A. Martins |
author_sort |
Maria Lúcia B. Garcia |
title |
Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice Neumonía eosinofílica inducida por aerosol de aceite diésel y piretroide en ratones |
title_short |
Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice Neumonía eosinofílica inducida por aerosol de aceite diésel y piretroide en ratones |
title_full |
Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice Neumonía eosinofílica inducida por aerosol de aceite diésel y piretroide en ratones |
title_fullStr |
Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice Neumonía eosinofílica inducida por aerosol de aceite diésel y piretroide en ratones |
title_full_unstemmed |
Eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice Neumonía eosinofílica inducida por aerosol de aceite diésel y piretroide en ratones |
title_sort |
eosinophilic pneumonitis induced by aerosol-administered diesel oil and pyrethrum to mice neumonía eosinofílica inducida por aerosol de aceite diésel y piretroide en ratones |
publisher |
Pan American Health Organization |
publishDate |
2009 |
url |
https://doaj.org/article/7b9470bec8644ab08d8384f948d0b5fc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 25, Iss 6, Pp 518-523 (2009) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892009000600008 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/7b9470bec8644ab08d8384f948d0b5fc |
_version_ |
1766348626984960000 |