Effect of Curcuma zedoaria crude extract against tumor progression and immunomodulation

• Published in: Journal of Venomous Animals and Toxins including Tropical Diseases
• Main Authors: FR Carvalho, RC Vassão, MA Nicoletti, DA Maria
• Format: Article in Journal/Newspaper
• Language: English
• Published: SciELO 2010
• Subjects: melanoma; tumor; hematology; Curcuma zedoaria; Arctic medicine. Tropical medicine; RC955-962; Toxicology. Poisons; RA1190-1270; Zoology; QL1-991; Arctic
• Online Access: https://doi.org/10.1590/S1678-91992010000200013; https://doaj.org/article/7b8a75c5b9da41ab81520fe1778ecbb7

The aim of the present work was to study the effect of the crude extract of Curcuma zedoaria on peripheral blood cells and tumor progression in C57Bl/6J mice injected with B16F10 murine melanoma cells. The intraperitoneal therapy showed a significant increase in total white and red blood cell counts, a decrease in peritoneal cell number and tumor volume reduction, whereas the oral administration revealed a noteworthy augmentation only in total leukocyte count. These results contribute to evaluate the importance of alternative treatments that employ phytotherapic compounds against tumor progression and its possible immunomodulation.