First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features.
BACKGROUND:In June 2014, Suriname faced the first Chikungunya outbreak. Since international reports mostly focus on hospitalized patients, the least affected group, a study was conducted to describe clinical characteristics of mainly outpatients including children. In addition, the cumulative incide...
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ftdoajarticles:oai:doaj.org/article:7b12ba87e1c146b2bdebcd5ee9ea3d9d 2023-05-15T15:16:09+02:00 First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features. Farah T van Genderen Ingrid Krishnadath Rachel Sno Meritha G Grunberg Wilco Zijlmans Malti R Adhin 2016-04-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004625 https://doaj.org/article/7b12ba87e1c146b2bdebcd5ee9ea3d9d EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC4833344?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004625 https://doaj.org/article/7b12ba87e1c146b2bdebcd5ee9ea3d9d PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004625 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004625 2022-12-31T01:15:53Z BACKGROUND:In June 2014, Suriname faced the first Chikungunya outbreak. Since international reports mostly focus on hospitalized patients, the least affected group, a study was conducted to describe clinical characteristics of mainly outpatients including children. In addition, the cumulative incidence of this first epidemic was investigated. METHODOLOGY:During August and September 2014, clinically suspected Chikungunya cases were included in a prospective follow-up study. Blood specimens were collected and tested for viral RNA presence. Detailed clinical information was gathered through multiple telephone surveys until day 180. In addition, a three stage household-based cluster with a cross-sectional design was conducted in October, December 2014 and March 2015 to assess the cumulative incidence. PRINCIPAL FINDINGS:Sixty-eight percent of symptomatic patients tested positive for Chikungunya virus (CHIKV). Arthralgia and pain in the fingers were distinctive for viremic CHIKV infected patients. Viremic CHIKV infected children (≤12 years) characteristically displayed headache and vomiting, while arthralgia was less common at onset. The disease was cleared within seven days by 20% of the patients, while 22% of the viremic CHIKV infected patients, mostly women and elderly reported persistent arthralgia at day 180. The extrapolated cumulative CHIKV incidence in Paramaribo was 249 cases per 1000 persons, based on CHIKV self-reported cases in 53.1% of the households and 90.4% IgG detected in a subset of self-reported CHIKV+ persons. CHIKV peaked in the dry season and a drastic decrease in CHIKV patients coincided with a governmental campaign to reduce mosquito breeding sites. CONCLUSIONS/SIGNIFICANCE:This study revealed that persistent arthralgia was a concern, but occurred less frequently in an outpatient setting. The data support a less severe pathological outcome for Caribbean CHIKV infections. This study augments incidence data available for first outbreaks in the region and showed that actions undertaken at the ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 4 e0004625 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Farah T van Genderen Ingrid Krishnadath Rachel Sno Meritha G Grunberg Wilco Zijlmans Malti R Adhin First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:In June 2014, Suriname faced the first Chikungunya outbreak. Since international reports mostly focus on hospitalized patients, the least affected group, a study was conducted to describe clinical characteristics of mainly outpatients including children. In addition, the cumulative incidence of this first epidemic was investigated. METHODOLOGY:During August and September 2014, clinically suspected Chikungunya cases were included in a prospective follow-up study. Blood specimens were collected and tested for viral RNA presence. Detailed clinical information was gathered through multiple telephone surveys until day 180. In addition, a three stage household-based cluster with a cross-sectional design was conducted in October, December 2014 and March 2015 to assess the cumulative incidence. PRINCIPAL FINDINGS:Sixty-eight percent of symptomatic patients tested positive for Chikungunya virus (CHIKV). Arthralgia and pain in the fingers were distinctive for viremic CHIKV infected patients. Viremic CHIKV infected children (≤12 years) characteristically displayed headache and vomiting, while arthralgia was less common at onset. The disease was cleared within seven days by 20% of the patients, while 22% of the viremic CHIKV infected patients, mostly women and elderly reported persistent arthralgia at day 180. The extrapolated cumulative CHIKV incidence in Paramaribo was 249 cases per 1000 persons, based on CHIKV self-reported cases in 53.1% of the households and 90.4% IgG detected in a subset of self-reported CHIKV+ persons. CHIKV peaked in the dry season and a drastic decrease in CHIKV patients coincided with a governmental campaign to reduce mosquito breeding sites. CONCLUSIONS/SIGNIFICANCE:This study revealed that persistent arthralgia was a concern, but occurred less frequently in an outpatient setting. The data support a less severe pathological outcome for Caribbean CHIKV infections. This study augments incidence data available for first outbreaks in the region and showed that actions undertaken at the ... |
format |
Article in Journal/Newspaper |
author |
Farah T van Genderen Ingrid Krishnadath Rachel Sno Meritha G Grunberg Wilco Zijlmans Malti R Adhin |
author_facet |
Farah T van Genderen Ingrid Krishnadath Rachel Sno Meritha G Grunberg Wilco Zijlmans Malti R Adhin |
author_sort |
Farah T van Genderen |
title |
First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features. |
title_short |
First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features. |
title_full |
First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features. |
title_fullStr |
First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features. |
title_full_unstemmed |
First Chikungunya Outbreak in Suriname; Clinical and Epidemiological Features. |
title_sort |
first chikungunya outbreak in suriname; clinical and epidemiological features. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004625 https://doaj.org/article/7b12ba87e1c146b2bdebcd5ee9ea3d9d |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 4, p e0004625 (2016) |
op_relation |
http://europepmc.org/articles/PMC4833344?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004625 https://doaj.org/article/7b12ba87e1c146b2bdebcd5ee9ea3d9d |
op_doi |
https://doi.org/10.1371/journal.pntd.0004625 |
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PLOS Neglected Tropical Diseases |
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10 |
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4 |
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e0004625 |
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