Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study
Objective: To develop and characterize multiple-unit-type oral floating microsphere of famotidine to prolong gastric residence time and to target stomach ulcer. Methods: The floating microspheres were prepared by modified solvent evaporation method. Eudragit S-100 was used as polymer. Microspheres w...
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:7afeaeb9b91549119be3b5434803f145 2023-05-15T15:08:19+02:00 Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study Rishikesh Gupta Sunil Kumar Prajapati Snigdha Pattnaik Peeyush Bhardwaj 2014-09-01T00:00:00Z https://doi.org/10.12980/APJTB.4.201414B73 https://doaj.org/article/7afeaeb9b91549119be3b5434803f145 EN eng Wolters Kluwer Medknow Publications http://www.sciencedirect.com/science/article/pii/S2221169115300964 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.201414B73 https://doaj.org/article/7afeaeb9b91549119be3b5434803f145 Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 9, Pp 729-735 (2014) Floating microspheres Famotidine Floating drug delivery Stomach targeting Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2014 ftdoajarticles https://doi.org/10.12980/APJTB.4.201414B73 2022-12-31T09:29:55Z Objective: To develop and characterize multiple-unit-type oral floating microsphere of famotidine to prolong gastric residence time and to target stomach ulcer. Methods: The floating microspheres were prepared by modified solvent evaporation method. Eudragit S-100 was used as polymer. Microspheres were characterized for the micromeritic properties, floating behavior, entrapment efficiency and scanning electron microscopy. The in-vitro release studies and floating behavior were studied in simulated gastric fluid at pH 1.2. Different drug release kinetics models were also applied for all the batches. Selected formulations were also subjected for X-ray radiographic study. Results: Floating microspheres were successfully prepared by modified solvent evaporation technique. Microspheres showed passable flow properties. The maximum yield of microspheres was up to (95.11±0.35)%. On the basis of optical microscopy particle size range was found to be ranging from (52.18±182.00) to (91.64±5.16) μm. Scanning electron microscopy showed their spherical size, perforated smooth surface and a cavity inside microspheres. Microspheres were capable to float up to 20 h in simulated gastric fluid. X-ray radiographic studies also proved its better retention in the stomach. Conclusions: On the basis of the results, such dosage forms may be a good candidate for stomach targeting and may be dispensed in hard gelatin capsules. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 4 9 729 735 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Floating microspheres Famotidine Floating drug delivery Stomach targeting Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
spellingShingle |
Floating microspheres Famotidine Floating drug delivery Stomach targeting Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Rishikesh Gupta Sunil Kumar Prajapati Snigdha Pattnaik Peeyush Bhardwaj Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study |
topic_facet |
Floating microspheres Famotidine Floating drug delivery Stomach targeting Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Objective: To develop and characterize multiple-unit-type oral floating microsphere of famotidine to prolong gastric residence time and to target stomach ulcer. Methods: The floating microspheres were prepared by modified solvent evaporation method. Eudragit S-100 was used as polymer. Microspheres were characterized for the micromeritic properties, floating behavior, entrapment efficiency and scanning electron microscopy. The in-vitro release studies and floating behavior were studied in simulated gastric fluid at pH 1.2. Different drug release kinetics models were also applied for all the batches. Selected formulations were also subjected for X-ray radiographic study. Results: Floating microspheres were successfully prepared by modified solvent evaporation technique. Microspheres showed passable flow properties. The maximum yield of microspheres was up to (95.11±0.35)%. On the basis of optical microscopy particle size range was found to be ranging from (52.18±182.00) to (91.64±5.16) μm. Scanning electron microscopy showed their spherical size, perforated smooth surface and a cavity inside microspheres. Microspheres were capable to float up to 20 h in simulated gastric fluid. X-ray radiographic studies also proved its better retention in the stomach. Conclusions: On the basis of the results, such dosage forms may be a good candidate for stomach targeting and may be dispensed in hard gelatin capsules. |
format |
Article in Journal/Newspaper |
author |
Rishikesh Gupta Sunil Kumar Prajapati Snigdha Pattnaik Peeyush Bhardwaj |
author_facet |
Rishikesh Gupta Sunil Kumar Prajapati Snigdha Pattnaik Peeyush Bhardwaj |
author_sort |
Rishikesh Gupta |
title |
Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study |
title_short |
Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study |
title_full |
Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study |
title_fullStr |
Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study |
title_full_unstemmed |
Formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study |
title_sort |
formulation and evaluation of novel stomach specific floating microspheres bearing famotidine for treatment of gastric ulcer and their radiographic study |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2014 |
url |
https://doi.org/10.12980/APJTB.4.201414B73 https://doaj.org/article/7afeaeb9b91549119be3b5434803f145 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 4, Iss 9, Pp 729-735 (2014) |
op_relation |
http://www.sciencedirect.com/science/article/pii/S2221169115300964 https://doaj.org/toc/2221-1691 2221-1691 doi:10.12980/APJTB.4.201414B73 https://doaj.org/article/7afeaeb9b91549119be3b5434803f145 |
op_doi |
https://doi.org/10.12980/APJTB.4.201414B73 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
4 |
container_issue |
9 |
container_start_page |
729 |
op_container_end_page |
735 |
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1766339705362710528 |