Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico.
Background Hospitalization of patients during outbreaks of chikungunya virus has been reported to be uncommon (0.5-8.7%), but more frequent among infants and the elderly. CHIKV was first detected in Puerto Rico in May 2014. We enrolled patients with acute febrile illness (AFI) presenting to two hosp...
Published in: | PLOS Neglected Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:7ac8689aeb8a4d3abaca2c8788522144 2023-05-15T15:15:29+02:00 Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. Christopher H Hsu Fabiola Cruz-Lopez Danulka Vargas Torres Janice Perez-Padilla Olga D Lorenzi Aidsa Rivera J Erin Staples Esteban Lugo Jorge Munoz-Jordan Marc Fischer Carlos Garcia Gubern Brenda Rivera Garcia Luisa Alvarado Tyler M Sharp 2019-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007084 https://doaj.org/article/7ac8689aeb8a4d3abaca2c8788522144 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007084 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007084 https://doaj.org/article/7ac8689aeb8a4d3abaca2c8788522144 PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007084 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007084 2022-12-31T05:52:39Z Background Hospitalization of patients during outbreaks of chikungunya virus has been reported to be uncommon (0.5-8.7%), but more frequent among infants and the elderly. CHIKV was first detected in Puerto Rico in May 2014. We enrolled patients with acute febrile illness (AFI) presenting to two hospital emergency departments in Puerto Rico and tested them for CHIKV infection to describe the frequency of detection of CHIKV-infected patients, identify risk factors for hospitalization, and describe patients with severe manifestations. Methodology/principal findings Serum specimens were collected from patients with AFI and tested by rRT-PCR. During May-December 2014, a total of 3,035 patients were enrolled, and 1,469 (48.4%) had CHIKV infection. A total of 157 (10.7%) CHIKV-infected patients were hospitalized, six (0.4%) were admitted to the intensive care unit, and two died (0.1%). Common symptoms among all CHIKV-infected patients were arthralgia (82.6%), lethargy (80.6%), and myalgia (80.5%). Compared to patients aged 1-69 years (7.3%), infant (67.2%) and elderly (17.3%) patients were nine and two times more likely to be hospitalized, respectively (relative risk [RR] and 95% confidence interval [CI] = 9.16 [7.05-11.90] and 2.36 [1.54-3.62]). Multiple symptoms of AFI were associated with decreased risk of hospitalization, including arthralgia (RR = 0.31 [0.23-0.41]) and myalgia (RR = 0.29 [0.22-0.39]). Respiratory symptoms were associated with increased risk of hospitalization, including rhinorrhea (RR = 1.68 [1.24-2.27) and cough (RR = 1.77 [1.31-2.39]). Manifestations present among <5% of patients but associated with patient hospitalization included cyanosis (RR = 2.20 [1.17-4.12) and seizures (RR = 3.23 [1.80-5.81). Discussion Among this cohort of CHIKV-infected patients, hospitalization was uncommon, admission to the ICU was infrequent, and death was rare. Risk of hospitalization was higher in patients with symptoms of respiratory illness and other manifestations that may not have been the result of CHIKV ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 1 e0007084 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Christopher H Hsu Fabiola Cruz-Lopez Danulka Vargas Torres Janice Perez-Padilla Olga D Lorenzi Aidsa Rivera J Erin Staples Esteban Lugo Jorge Munoz-Jordan Marc Fischer Carlos Garcia Gubern Brenda Rivera Garcia Luisa Alvarado Tyler M Sharp Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Hospitalization of patients during outbreaks of chikungunya virus has been reported to be uncommon (0.5-8.7%), but more frequent among infants and the elderly. CHIKV was first detected in Puerto Rico in May 2014. We enrolled patients with acute febrile illness (AFI) presenting to two hospital emergency departments in Puerto Rico and tested them for CHIKV infection to describe the frequency of detection of CHIKV-infected patients, identify risk factors for hospitalization, and describe patients with severe manifestations. Methodology/principal findings Serum specimens were collected from patients with AFI and tested by rRT-PCR. During May-December 2014, a total of 3,035 patients were enrolled, and 1,469 (48.4%) had CHIKV infection. A total of 157 (10.7%) CHIKV-infected patients were hospitalized, six (0.4%) were admitted to the intensive care unit, and two died (0.1%). Common symptoms among all CHIKV-infected patients were arthralgia (82.6%), lethargy (80.6%), and myalgia (80.5%). Compared to patients aged 1-69 years (7.3%), infant (67.2%) and elderly (17.3%) patients were nine and two times more likely to be hospitalized, respectively (relative risk [RR] and 95% confidence interval [CI] = 9.16 [7.05-11.90] and 2.36 [1.54-3.62]). Multiple symptoms of AFI were associated with decreased risk of hospitalization, including arthralgia (RR = 0.31 [0.23-0.41]) and myalgia (RR = 0.29 [0.22-0.39]). Respiratory symptoms were associated with increased risk of hospitalization, including rhinorrhea (RR = 1.68 [1.24-2.27) and cough (RR = 1.77 [1.31-2.39]). Manifestations present among <5% of patients but associated with patient hospitalization included cyanosis (RR = 2.20 [1.17-4.12) and seizures (RR = 3.23 [1.80-5.81). Discussion Among this cohort of CHIKV-infected patients, hospitalization was uncommon, admission to the ICU was infrequent, and death was rare. Risk of hospitalization was higher in patients with symptoms of respiratory illness and other manifestations that may not have been the result of CHIKV ... |
format |
Article in Journal/Newspaper |
author |
Christopher H Hsu Fabiola Cruz-Lopez Danulka Vargas Torres Janice Perez-Padilla Olga D Lorenzi Aidsa Rivera J Erin Staples Esteban Lugo Jorge Munoz-Jordan Marc Fischer Carlos Garcia Gubern Brenda Rivera Garcia Luisa Alvarado Tyler M Sharp |
author_facet |
Christopher H Hsu Fabiola Cruz-Lopez Danulka Vargas Torres Janice Perez-Padilla Olga D Lorenzi Aidsa Rivera J Erin Staples Esteban Lugo Jorge Munoz-Jordan Marc Fischer Carlos Garcia Gubern Brenda Rivera Garcia Luisa Alvarado Tyler M Sharp |
author_sort |
Christopher H Hsu |
title |
Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. |
title_short |
Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. |
title_full |
Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. |
title_fullStr |
Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. |
title_full_unstemmed |
Risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in Puerto Rico. |
title_sort |
risk factors for hospitalization of patients with chikungunya virus infection at sentinel hospitals in puerto rico. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007084 https://doaj.org/article/7ac8689aeb8a4d3abaca2c8788522144 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 1, p e0007084 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007084 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007084 https://doaj.org/article/7ac8689aeb8a4d3abaca2c8788522144 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007084 |
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PLOS Neglected Tropical Diseases |
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13 |
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e0007084 |
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