Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan
Abstract Background Early diagnosis and effective treatment with an appropriate drug form the main components of the World Health Organization's strategy to reduce malaria related mortality. The few available drugs might be safeguarded if combined with artesunate. The addition of artesunate to...
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ftdoajarticles:oai:doaj.org/article:7ab0d60d8b7f42afb12cb0fe3b797676 2023-05-15T15:08:59+02:00 Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan Ahmed Elderderi S Khamiss Ammar H Mohammed Mamoun M Abdelgadir Tarig Malik Elfatih M Elamin Sakina B Adam Ishag 2005-09-01T00:00:00Z https://doi.org/10.1186/1475-2875-4-41 https://doaj.org/article/7ab0d60d8b7f42afb12cb0fe3b797676 EN eng BMC http://www.malariajournal.com/content/4/1/41 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-4-41 1475-2875 https://doaj.org/article/7ab0d60d8b7f42afb12cb0fe3b797676 Malaria Journal, Vol 4, Iss 1, p 41 (2005) Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 article 2005 ftdoajarticles https://doi.org/10.1186/1475-2875-4-41 2022-12-31T11:46:37Z Abstract Background Early diagnosis and effective treatment with an appropriate drug form the main components of the World Health Organization's strategy to reduce malaria related mortality. The few available drugs might be safeguarded if combined with artesunate. The addition of artesunate to a standard antimalarial treatment substantially reduces treatment failure, recrudescence and gametocyte carriage. Methods During late 2004, the efficacy of artesunate (4 mg/kg. day, on days 0–2) plus sulfadoxine-pyrimethamine (25 mg/kg, on day 0) for the treatment of uncomplicated Plasmodium falciparum malaria was investigated in four sentinel areas in Sudan, with different malaria transmission (Damazin, Kassala, Kosti, and Malakal). Results Two hundreds and sixty-nine patients completed the 28-day follow-up. On day one, 60 (22.3%) patients were febrile and 15 (5.5%) patients were parasitaemic. On day three, all the patients were afebrile and aparasitaemic. While two patients (0.7%, Kassala) showed late Clinical and Parasitological Failures, the rest (99.3%) of the patients demonstrated Adequate Clinical and Parasitological Response. A gametocytaemia were detected during the follow-up in one patient (0.37%, Kassala). Adverse drug effects were detected in 32 (11.9%) patients Conclusion The study showed that AS plus SP is an effective, safe drug in the treatment of uncomplicated P. falciparum malaria in Sudan. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Malaria Journal 4 1 41 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
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Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 Ahmed Elderderi S Khamiss Ammar H Mohammed Mamoun M Abdelgadir Tarig Malik Elfatih M Elamin Sakina B Adam Ishag Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Infectious and parasitic diseases RC109-216 |
description |
Abstract Background Early diagnosis and effective treatment with an appropriate drug form the main components of the World Health Organization's strategy to reduce malaria related mortality. The few available drugs might be safeguarded if combined with artesunate. The addition of artesunate to a standard antimalarial treatment substantially reduces treatment failure, recrudescence and gametocyte carriage. Methods During late 2004, the efficacy of artesunate (4 mg/kg. day, on days 0–2) plus sulfadoxine-pyrimethamine (25 mg/kg, on day 0) for the treatment of uncomplicated Plasmodium falciparum malaria was investigated in four sentinel areas in Sudan, with different malaria transmission (Damazin, Kassala, Kosti, and Malakal). Results Two hundreds and sixty-nine patients completed the 28-day follow-up. On day one, 60 (22.3%) patients were febrile and 15 (5.5%) patients were parasitaemic. On day three, all the patients were afebrile and aparasitaemic. While two patients (0.7%, Kassala) showed late Clinical and Parasitological Failures, the rest (99.3%) of the patients demonstrated Adequate Clinical and Parasitological Response. A gametocytaemia were detected during the follow-up in one patient (0.37%, Kassala). Adverse drug effects were detected in 32 (11.9%) patients Conclusion The study showed that AS plus SP is an effective, safe drug in the treatment of uncomplicated P. falciparum malaria in Sudan. |
format |
Article in Journal/Newspaper |
author |
Ahmed Elderderi S Khamiss Ammar H Mohammed Mamoun M Abdelgadir Tarig Malik Elfatih M Elamin Sakina B Adam Ishag |
author_facet |
Ahmed Elderderi S Khamiss Ammar H Mohammed Mamoun M Abdelgadir Tarig Malik Elfatih M Elamin Sakina B Adam Ishag |
author_sort |
Ahmed Elderderi S |
title |
Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
title_short |
Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
title_full |
Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
title_fullStr |
Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
title_full_unstemmed |
Artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated Plasmodium falciparum malaria in Sudan |
title_sort |
artesunate plus sulfadoxine-pyrimethamine for treatment of uncomplicated plasmodium falciparum malaria in sudan |
publisher |
BMC |
publishDate |
2005 |
url |
https://doi.org/10.1186/1475-2875-4-41 https://doaj.org/article/7ab0d60d8b7f42afb12cb0fe3b797676 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Malaria Journal, Vol 4, Iss 1, p 41 (2005) |
op_relation |
http://www.malariajournal.com/content/4/1/41 https://doaj.org/toc/1475-2875 doi:10.1186/1475-2875-4-41 1475-2875 https://doaj.org/article/7ab0d60d8b7f42afb12cb0fe3b797676 |
op_doi |
https://doi.org/10.1186/1475-2875-4-41 |
container_title |
Malaria Journal |
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4 |
container_issue |
1 |
container_start_page |
41 |
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