Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens
The immune response in leishmaniasis may result in a polarization of the T lymphocyte subpopulation, altering cell phenotype and resulting in immune protection or disease exacerbation. Leishmania may persist in the body either during asymptomatic infections or after treatment, which represents high...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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Online Access: | https://doi.org/10.1590/S1678-91992009000300004 https://doaj.org/article/7a7c451a9df6487db89ec91d90551971 |
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ftdoajarticles:oai:doaj.org/article:7a7c451a9df6487db89ec91d90551971 2023-05-15T15:06:21+02:00 Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens JL Hoffmann JG Machado FC Gaio LA Dias-Melicio H Langoni 2009-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992009000300004 https://doaj.org/article/7a7c451a9df6487db89ec91d90551971 EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300004 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000300004 1678-9199 https://doaj.org/article/7a7c451a9df6487db89ec91d90551971 Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 3, Pp 391-410 (2009) Leishmania chagasI immunosuppression cell-mediated response parasite burden experimental infection Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2009 ftdoajarticles https://doi.org/10.1590/S1678-91992009000300004 2022-12-31T16:26:38Z The immune response in leishmaniasis may result in a polarization of the T lymphocyte subpopulation, altering cell phenotype and resulting in immune protection or disease exacerbation. Leishmania may persist in the body either during asymptomatic infections or after treatment, which represents high risk under immunosuppression. The objective of this study was to evaluate the effect of infection with immunosuppression by dexamethasone associated with pentoxifylline on animal weight, spleen weight, spleen and hepatic parasitic load and immunopathology, as well as the IFN-γ and IL-10 production in spleen cell culture of Balb/c mice infected with Leishmania chagasi. The infection did not cause body weight gain in animals, but both the weight and size of the spleen were increased. The immunosuppression using dexamethasone associated with pentoxifylline affected body weight gain and spleen weight and size in both infected and non-infected animals. The immunosuppression did not significantly alter the course of the splenic or hepatic parasite burden. Dexamethasone and pentoxifylline significantly affected cytokine production, but did not influence the Th1/Th2 ratio in infected animals. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 15 3 391 410 |
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Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Leishmania chagasI immunosuppression cell-mediated response parasite burden experimental infection Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
Leishmania chagasI immunosuppression cell-mediated response parasite burden experimental infection Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 JL Hoffmann JG Machado FC Gaio LA Dias-Melicio H Langoni Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens |
topic_facet |
Leishmania chagasI immunosuppression cell-mediated response parasite burden experimental infection Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The immune response in leishmaniasis may result in a polarization of the T lymphocyte subpopulation, altering cell phenotype and resulting in immune protection or disease exacerbation. Leishmania may persist in the body either during asymptomatic infections or after treatment, which represents high risk under immunosuppression. The objective of this study was to evaluate the effect of infection with immunosuppression by dexamethasone associated with pentoxifylline on animal weight, spleen weight, spleen and hepatic parasitic load and immunopathology, as well as the IFN-γ and IL-10 production in spleen cell culture of Balb/c mice infected with Leishmania chagasi. The infection did not cause body weight gain in animals, but both the weight and size of the spleen were increased. The immunosuppression using dexamethasone associated with pentoxifylline affected body weight gain and spleen weight and size in both infected and non-infected animals. The immunosuppression did not significantly alter the course of the splenic or hepatic parasite burden. Dexamethasone and pentoxifylline significantly affected cytokine production, but did not influence the Th1/Th2 ratio in infected animals. |
format |
Article in Journal/Newspaper |
author |
JL Hoffmann JG Machado FC Gaio LA Dias-Melicio H Langoni |
author_facet |
JL Hoffmann JG Machado FC Gaio LA Dias-Melicio H Langoni |
author_sort |
JL Hoffmann |
title |
Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens |
title_short |
Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens |
title_full |
Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens |
title_fullStr |
Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens |
title_full_unstemmed |
Experimental infection with Leishmania chagasi in immunosuppressed Balb/c mice: cytokines and parasite burdens |
title_sort |
experimental infection with leishmania chagasi in immunosuppressed balb/c mice: cytokines and parasite burdens |
publisher |
SciELO |
publishDate |
2009 |
url |
https://doi.org/10.1590/S1678-91992009000300004 https://doaj.org/article/7a7c451a9df6487db89ec91d90551971 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 15, Iss 3, Pp 391-410 (2009) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992009000300004 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992009000300004 1678-9199 https://doaj.org/article/7a7c451a9df6487db89ec91d90551971 |
op_doi |
https://doi.org/10.1590/S1678-91992009000300004 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
15 |
container_issue |
3 |
container_start_page |
391 |
op_container_end_page |
410 |
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1766337974164783104 |