A cluster-randomized controlled trial of handrubs for prevention of infectious diseases among children in Colombia Ensayo controlado aleatorizado por conglomerados sobre el uso de antisépticos para las manos para la prevención de enfermedades infecciosas en los niños en Colombia
OBJECTIVE: To evaluate the effectiveness of alcohol-based handrubs (ABH) in reducing acute diarrheal diseases (ADD) and acute respiratory infections (ARI) among children 1-5 years of age in childcare centers with limited tap water. METHODS: This was the first cluster-randomized controlled trial in a...
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Pan American Health Organization
2012
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ftdoajarticles:oai:doaj.org/article:7a1642aae79e4497987be6a8ffd5938e 2023-05-15T15:19:26+02:00 A cluster-randomized controlled trial of handrubs for prevention of infectious diseases among children in Colombia Ensayo controlado aleatorizado por conglomerados sobre el uso de antisépticos para las manos para la prevención de enfermedades infecciosas en los niños en Colombia Juan C. Correa Diana Pinto Lucas A. Salas Juan C. Camacho Martín Rondón Juliana Quintero 2012-06-01T00:00:00Z https://doaj.org/article/7a1642aae79e4497987be6a8ffd5938e EN ES PT eng spa por Pan American Health Organization http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892012000600005 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/7a1642aae79e4497987be6a8ffd5938e Revista Panamericana de Salud Pública, Vol 31, Iss 6, Pp 476-484 (2012) Lavado de manos antiinfecciosos locales enfermedades gastrointestinales infecciones del sistema respiratorio diarrea etanol preescolar países en desarrollo ensayos clínicos controlados aleatorios como asunto Colombia Handwashing anti-infective agents local gastrointestinal diseases respiratory tract infections diarrhea ethanol child preschool developing countries randomized controlled trials as topic Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2012 ftdoajarticles 2022-12-30T21:58:10Z OBJECTIVE: To evaluate the effectiveness of alcohol-based handrubs (ABH) in reducing acute diarrheal diseases (ADD) and acute respiratory infections (ARI) among children 1-5 years of age in childcare centers with limited tap water. METHODS: This was the first cluster-randomized controlled trial in a developing country. The study took place at 42 childcare centers with sporadic and limited water availability in six towns in Colombia. Participants were randomly assigned to use ABH as a complement to handwashing (intervention arm: 21 centers/794 children); or to continue existing handwashing practices (control arm: 21 centers/933 children). ADD and ARI cases were identified through teacher-reported signs and symptoms of illness. Adverse events were monitored. Hazard ratios (HR) were obtained using Cox proportional hazards multivariate regression shared frailty models. RESULTS: Child-days of surveillance totaled 336 038. Loss to follow up was 14.5%. For both ADD and ARI, there were no differences in hazard ratios during the first trimester of the study. In the second and third trimesters, significant reductions in the risk of ADD were found in the intervention compared to control arm (HR = 0.55, P < 0.001 and HR = 0.44, P < 0.001, respectively). There were also significant risk reductions for ARI in the second trimester (HR = 0.80, P < 0.05) and in the third trimester (HR = 0.69, P < 0.001). No adverse events occurred. CONCLUSIONS: ABH effectively prevent ADD and ARI, and are safe. Colombia's national public health policies for prevention of these diseases should include use of ABH, especially in settings where handwashing with soap and water is limited by water availability. OBJETIVO: Evaluar la eficacia del uso de antisépticos para las manos a base de alcohol en la disminución de las enfermedades diarreicas agudas y las infecciones respiratorias agudas en niños de 1 a 5 años de edad en los centros de atención infantil donde el lavado de las manos con agua y jabón no es factible. MÉTODOS. El presente ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Ari ENVELOPE(147.813,147.813,59.810,59.810) |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English Spanish Portuguese |
topic |
Lavado de manos antiinfecciosos locales enfermedades gastrointestinales infecciones del sistema respiratorio diarrea etanol preescolar países en desarrollo ensayos clínicos controlados aleatorios como asunto Colombia Handwashing anti-infective agents local gastrointestinal diseases respiratory tract infections diarrhea ethanol child preschool developing countries randomized controlled trials as topic Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Lavado de manos antiinfecciosos locales enfermedades gastrointestinales infecciones del sistema respiratorio diarrea etanol preescolar países en desarrollo ensayos clínicos controlados aleatorios como asunto Colombia Handwashing anti-infective agents local gastrointestinal diseases respiratory tract infections diarrhea ethanol child preschool developing countries randomized controlled trials as topic Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Juan C. Correa Diana Pinto Lucas A. Salas Juan C. Camacho Martín Rondón Juliana Quintero A cluster-randomized controlled trial of handrubs for prevention of infectious diseases among children in Colombia Ensayo controlado aleatorizado por conglomerados sobre el uso de antisépticos para las manos para la prevención de enfermedades infecciosas en los niños en Colombia |
topic_facet |
Lavado de manos antiinfecciosos locales enfermedades gastrointestinales infecciones del sistema respiratorio diarrea etanol preescolar países en desarrollo ensayos clínicos controlados aleatorios como asunto Colombia Handwashing anti-infective agents local gastrointestinal diseases respiratory tract infections diarrhea ethanol child preschool developing countries randomized controlled trials as topic Medicine R Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
OBJECTIVE: To evaluate the effectiveness of alcohol-based handrubs (ABH) in reducing acute diarrheal diseases (ADD) and acute respiratory infections (ARI) among children 1-5 years of age in childcare centers with limited tap water. METHODS: This was the first cluster-randomized controlled trial in a developing country. The study took place at 42 childcare centers with sporadic and limited water availability in six towns in Colombia. Participants were randomly assigned to use ABH as a complement to handwashing (intervention arm: 21 centers/794 children); or to continue existing handwashing practices (control arm: 21 centers/933 children). ADD and ARI cases were identified through teacher-reported signs and symptoms of illness. Adverse events were monitored. Hazard ratios (HR) were obtained using Cox proportional hazards multivariate regression shared frailty models. RESULTS: Child-days of surveillance totaled 336 038. Loss to follow up was 14.5%. For both ADD and ARI, there were no differences in hazard ratios during the first trimester of the study. In the second and third trimesters, significant reductions in the risk of ADD were found in the intervention compared to control arm (HR = 0.55, P < 0.001 and HR = 0.44, P < 0.001, respectively). There were also significant risk reductions for ARI in the second trimester (HR = 0.80, P < 0.05) and in the third trimester (HR = 0.69, P < 0.001). No adverse events occurred. CONCLUSIONS: ABH effectively prevent ADD and ARI, and are safe. Colombia's national public health policies for prevention of these diseases should include use of ABH, especially in settings where handwashing with soap and water is limited by water availability. OBJETIVO: Evaluar la eficacia del uso de antisépticos para las manos a base de alcohol en la disminución de las enfermedades diarreicas agudas y las infecciones respiratorias agudas en niños de 1 a 5 años de edad en los centros de atención infantil donde el lavado de las manos con agua y jabón no es factible. MÉTODOS. El presente ... |
format |
Article in Journal/Newspaper |
author |
Juan C. Correa Diana Pinto Lucas A. Salas Juan C. Camacho Martín Rondón Juliana Quintero |
author_facet |
Juan C. Correa Diana Pinto Lucas A. Salas Juan C. Camacho Martín Rondón Juliana Quintero |
author_sort |
Juan C. Correa |
title |
A cluster-randomized controlled trial of handrubs for prevention of infectious diseases among children in Colombia Ensayo controlado aleatorizado por conglomerados sobre el uso de antisépticos para las manos para la prevención de enfermedades infecciosas en los niños en Colombia |
title_short |
A cluster-randomized controlled trial of handrubs for prevention of infectious diseases among children in Colombia Ensayo controlado aleatorizado por conglomerados sobre el uso de antisépticos para las manos para la prevención de enfermedades infecciosas en los niños en Colombia |
title_full |
A cluster-randomized controlled trial of handrubs for prevention of infectious diseases among children in Colombia Ensayo controlado aleatorizado por conglomerados sobre el uso de antisépticos para las manos para la prevención de enfermedades infecciosas en los niños en Colombia |
title_fullStr |
A cluster-randomized controlled trial of handrubs for prevention of infectious diseases among children in Colombia Ensayo controlado aleatorizado por conglomerados sobre el uso de antisépticos para las manos para la prevención de enfermedades infecciosas en los niños en Colombia |
title_full_unstemmed |
A cluster-randomized controlled trial of handrubs for prevention of infectious diseases among children in Colombia Ensayo controlado aleatorizado por conglomerados sobre el uso de antisépticos para las manos para la prevención de enfermedades infecciosas en los niños en Colombia |
title_sort |
cluster-randomized controlled trial of handrubs for prevention of infectious diseases among children in colombia ensayo controlado aleatorizado por conglomerados sobre el uso de antisépticos para las manos para la prevención de enfermedades infecciosas en los niños en colombia |
publisher |
Pan American Health Organization |
publishDate |
2012 |
url |
https://doaj.org/article/7a1642aae79e4497987be6a8ffd5938e |
long_lat |
ENVELOPE(147.813,147.813,59.810,59.810) |
geographic |
Arctic Ari |
geographic_facet |
Arctic Ari |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista Panamericana de Salud Pública, Vol 31, Iss 6, Pp 476-484 (2012) |
op_relation |
http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S1020-49892012000600005 https://doaj.org/toc/1020-4989 https://doaj.org/toc/1680-5348 1020-4989 1680-5348 https://doaj.org/article/7a1642aae79e4497987be6a8ffd5938e |
_version_ |
1766349626828390400 |