Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa.
BACKGROUND: Schistosomiasis is a water-based disease that is believed to affect over 200 million people with an estimated 97% of the infections concentrated in Africa. However, these statistics are largely based on population re-adjusted data originally published by Utroska and colleagues more than...
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ftdoajarticles:oai:doaj.org/article:7a0abe0ca4f54279aa7f82340b50ff29 2023-05-15T15:15:51+02:00 Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa. Nadine Schur Eveline Hürlimann Amadou Garba Mamadou S Traoré Omar Ndir Raoult C Ratard Louis-Albert Tchuem Tchuenté Thomas K Kristensen Jürg Utzinger Penelope Vounatsou 2011-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0001194 https://doaj.org/article/7a0abe0ca4f54279aa7f82340b50ff29 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC3114755?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001194 https://doaj.org/article/7a0abe0ca4f54279aa7f82340b50ff29 PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1194 (2011) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2011 ftdoajarticles https://doi.org/10.1371/journal.pntd.0001194 2022-12-31T10:44:51Z BACKGROUND: Schistosomiasis is a water-based disease that is believed to affect over 200 million people with an estimated 97% of the infections concentrated in Africa. However, these statistics are largely based on population re-adjusted data originally published by Utroska and colleagues more than 20 years ago. Hence, these estimates are outdated due to large-scale preventive chemotherapy programs, improved sanitation, water resources development and management, among other reasons. For planning, coordination, and evaluation of control activities, it is essential to possess reliable schistosomiasis prevalence maps. METHODOLOGY: We analyzed survey data compiled on a newly established open-access global neglected tropical diseases database (i) to create smooth empirical prevalence maps for Schistosoma mansoni and S. haematobium for individuals aged ≤ 20 years in West Africa, including Cameroon, and (ii) to derive country-specific prevalence estimates. We used Bayesian geostatistical models based on environmental predictors to take into account potential clustering due to common spatially structured exposures. Prediction at unobserved locations was facilitated by joint kriging. PRINCIPAL FINDINGS: Our models revealed that 50.8 million individuals aged ≤ 20 years in West Africa are infected with either S. mansoni, or S. haematobium, or both species concurrently. The country prevalence estimates ranged between 0.5% (The Gambia) and 37.1% (Liberia) for S. mansoni, and between 17.6% (The Gambia) and 51.6% (Sierra Leone) for S. haematobium. We observed that the combined prevalence for both schistosome species is two-fold lower in Gambia than previously reported, while we found an almost two-fold higher estimate for Liberia (58.3%) than reported before (30.0%). Our predictions are likely to overestimate overall country prevalence, since modeling was based on children and adolescents up to the age of 20 years who are at highest risk of infection. CONCLUSION/SIGNIFICANCE: We present the first empirical estimates for S. ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLoS Neglected Tropical Diseases 5 6 e1194 |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Nadine Schur Eveline Hürlimann Amadou Garba Mamadou S Traoré Omar Ndir Raoult C Ratard Louis-Albert Tchuem Tchuenté Thomas K Kristensen Jürg Utzinger Penelope Vounatsou Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND: Schistosomiasis is a water-based disease that is believed to affect over 200 million people with an estimated 97% of the infections concentrated in Africa. However, these statistics are largely based on population re-adjusted data originally published by Utroska and colleagues more than 20 years ago. Hence, these estimates are outdated due to large-scale preventive chemotherapy programs, improved sanitation, water resources development and management, among other reasons. For planning, coordination, and evaluation of control activities, it is essential to possess reliable schistosomiasis prevalence maps. METHODOLOGY: We analyzed survey data compiled on a newly established open-access global neglected tropical diseases database (i) to create smooth empirical prevalence maps for Schistosoma mansoni and S. haematobium for individuals aged ≤ 20 years in West Africa, including Cameroon, and (ii) to derive country-specific prevalence estimates. We used Bayesian geostatistical models based on environmental predictors to take into account potential clustering due to common spatially structured exposures. Prediction at unobserved locations was facilitated by joint kriging. PRINCIPAL FINDINGS: Our models revealed that 50.8 million individuals aged ≤ 20 years in West Africa are infected with either S. mansoni, or S. haematobium, or both species concurrently. The country prevalence estimates ranged between 0.5% (The Gambia) and 37.1% (Liberia) for S. mansoni, and between 17.6% (The Gambia) and 51.6% (Sierra Leone) for S. haematobium. We observed that the combined prevalence for both schistosome species is two-fold lower in Gambia than previously reported, while we found an almost two-fold higher estimate for Liberia (58.3%) than reported before (30.0%). Our predictions are likely to overestimate overall country prevalence, since modeling was based on children and adolescents up to the age of 20 years who are at highest risk of infection. CONCLUSION/SIGNIFICANCE: We present the first empirical estimates for S. ... |
format |
Article in Journal/Newspaper |
author |
Nadine Schur Eveline Hürlimann Amadou Garba Mamadou S Traoré Omar Ndir Raoult C Ratard Louis-Albert Tchuem Tchuenté Thomas K Kristensen Jürg Utzinger Penelope Vounatsou |
author_facet |
Nadine Schur Eveline Hürlimann Amadou Garba Mamadou S Traoré Omar Ndir Raoult C Ratard Louis-Albert Tchuem Tchuenté Thomas K Kristensen Jürg Utzinger Penelope Vounatsou |
author_sort |
Nadine Schur |
title |
Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa. |
title_short |
Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa. |
title_full |
Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa. |
title_fullStr |
Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa. |
title_full_unstemmed |
Geostatistical model-based estimates of Schistosomiasis prevalence among individuals aged ≤ 20 years in West Africa. |
title_sort |
geostatistical model-based estimates of schistosomiasis prevalence among individuals aged ≤ 20 years in west africa. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2011 |
url |
https://doi.org/10.1371/journal.pntd.0001194 https://doaj.org/article/7a0abe0ca4f54279aa7f82340b50ff29 |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 5, Iss 6, p e1194 (2011) |
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http://europepmc.org/articles/PMC3114755?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0001194 https://doaj.org/article/7a0abe0ca4f54279aa7f82340b50ff29 |
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https://doi.org/10.1371/journal.pntd.0001194 |
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PLoS Neglected Tropical Diseases |
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e1194 |
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