Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease
Alzheimer disease (AD) as worldwide progressive neurodegenerative disease is prevalent disease among elderly population. Due to limitation in chemical drugs along with their adverse effects of these treatments, research for finding more effective natural drugs, is one of interesting subjects among t...
Published in: | Asian Pacific Journal of Tropical Biomedicine |
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Wolters Kluwer Medknow Publications
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ftdoajarticles:oai:doaj.org/article:79c5a8a5def84c5ca7cae9bc60f0fa3a 2023-05-15T15:07:30+02:00 Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease Mohaddese Mahboubi 2019-01-01T00:00:00Z https://doi.org/10.4103/2221-1691.250849 https://doaj.org/article/79c5a8a5def84c5ca7cae9bc60f0fa3a EN eng Wolters Kluwer Medknow Publications http://www.apjtb.org/article.asp?issn=2221-1691;year=2019;volume=9;issue=2;spage=47;epage=52;aulast=Mahboubi https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.250849 https://doaj.org/article/79c5a8a5def84c5ca7cae9bc60f0fa3a Asian Pacific Journal of Tropical Biomedicine, Vol 9, Iss 2, Pp 47-52 (2019) lemon balm melissa officinalis alzheimer acetylcholine rosmarinic acid Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 article 2019 ftdoajarticles https://doi.org/10.4103/2221-1691.250849 2022-12-31T16:34:19Z Alzheimer disease (AD) as worldwide progressive neurodegenerative disease is prevalent disease among elderly population. Due to limitation in chemical drugs along with their adverse effects of these treatments, research for finding more effective natural drugs, is one of interesting subjects among the scientists. Melissa officinalis (M. officinalis) has a long history of use in treatment of nervous system diseases. This review article evaluates the potency of M. officinalis in treatment of AD by review of experimental and clinical documents on the efficacy, safety and its mechanisms of action in management of AD. The information is extracted from electronic resources (PubMed, Wiley, Springer and Science Direct), English and Persian scientific books. In spite of different scientific and non-scientific reports on the use of M. officinalis and its main component of rosmarinic acid in neurodegenerative diseases, there is only one clinical trial on the efficacy of M. officinalis ethanol extract in management of AD. Different mechanisms of action for M. officinalis, including inhibitory effects against amyloid beta, reactive oxygen species, and acetylcholine esterase, are involved. Larger clinical trials are recommended to confirm the efficacy and safety of M. officinalis extracts in treatment of AD patients. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Asian Pacific Journal of Tropical Biomedicine 9 2 47 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
lemon balm melissa officinalis alzheimer acetylcholine rosmarinic acid Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
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lemon balm melissa officinalis alzheimer acetylcholine rosmarinic acid Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 Mohaddese Mahboubi Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease |
topic_facet |
lemon balm melissa officinalis alzheimer acetylcholine rosmarinic acid Arctic medicine. Tropical medicine RC955-962 Biology (General) QH301-705.5 |
description |
Alzheimer disease (AD) as worldwide progressive neurodegenerative disease is prevalent disease among elderly population. Due to limitation in chemical drugs along with their adverse effects of these treatments, research for finding more effective natural drugs, is one of interesting subjects among the scientists. Melissa officinalis (M. officinalis) has a long history of use in treatment of nervous system diseases. This review article evaluates the potency of M. officinalis in treatment of AD by review of experimental and clinical documents on the efficacy, safety and its mechanisms of action in management of AD. The information is extracted from electronic resources (PubMed, Wiley, Springer and Science Direct), English and Persian scientific books. In spite of different scientific and non-scientific reports on the use of M. officinalis and its main component of rosmarinic acid in neurodegenerative diseases, there is only one clinical trial on the efficacy of M. officinalis ethanol extract in management of AD. Different mechanisms of action for M. officinalis, including inhibitory effects against amyloid beta, reactive oxygen species, and acetylcholine esterase, are involved. Larger clinical trials are recommended to confirm the efficacy and safety of M. officinalis extracts in treatment of AD patients. |
format |
Article in Journal/Newspaper |
author |
Mohaddese Mahboubi |
author_facet |
Mohaddese Mahboubi |
author_sort |
Mohaddese Mahboubi |
title |
Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease |
title_short |
Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease |
title_full |
Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease |
title_fullStr |
Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease |
title_full_unstemmed |
Melissa officinalis and rosmarinic acid in management of memory functions and Alzheimer disease |
title_sort |
melissa officinalis and rosmarinic acid in management of memory functions and alzheimer disease |
publisher |
Wolters Kluwer Medknow Publications |
publishDate |
2019 |
url |
https://doi.org/10.4103/2221-1691.250849 https://doaj.org/article/79c5a8a5def84c5ca7cae9bc60f0fa3a |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Asian Pacific Journal of Tropical Biomedicine, Vol 9, Iss 2, Pp 47-52 (2019) |
op_relation |
http://www.apjtb.org/article.asp?issn=2221-1691;year=2019;volume=9;issue=2;spage=47;epage=52;aulast=Mahboubi https://doaj.org/toc/2221-1691 2221-1691 doi:10.4103/2221-1691.250849 https://doaj.org/article/79c5a8a5def84c5ca7cae9bc60f0fa3a |
op_doi |
https://doi.org/10.4103/2221-1691.250849 |
container_title |
Asian Pacific Journal of Tropical Biomedicine |
container_volume |
9 |
container_issue |
2 |
container_start_page |
47 |
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