Environmental enteric dysfunction pathways and child stunting: A systematic review.
Environmental enteric dysfunction (EED) is commonly defined as an acquired subclinical disorder of the small intestine, characterized by villous atrophy and crypt hyperplasia. EED has been proposed to underlie stunted growth among children in developing countries. A collection of biomarkers, organiz...
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ftdoajarticles:oai:doaj.org/article:7976463db31c4482ba83497860bbd2fe 2023-05-15T15:10:47+02:00 Environmental enteric dysfunction pathways and child stunting: A systematic review. Kaitlyn M Harper Maxine Mutasa Andrew J Prendergast Jean Humphrey Amee R Manges 2018-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0006205 https://doaj.org/article/7976463db31c4482ba83497860bbd2fe EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5792022?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006205 https://doaj.org/article/7976463db31c4482ba83497860bbd2fe PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006205 (2018) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2018 ftdoajarticles https://doi.org/10.1371/journal.pntd.0006205 2023-01-08T01:27:15Z Environmental enteric dysfunction (EED) is commonly defined as an acquired subclinical disorder of the small intestine, characterized by villous atrophy and crypt hyperplasia. EED has been proposed to underlie stunted growth among children in developing countries. A collection of biomarkers, organized into distinct domains, has been used to measure different aspects of EED. Here, we examine whether these hypothesized relationships, among EED domains and between each domain and stunting, are supported by data from recent studies.A systematic literature search was conducted using PubMed, MEDLINE, EMBASE, Web of Science, and CINAHL between January 1, 2010 and April 20, 2017. Information on study objective, design, population, location, biomarkers, and results were recorded, as well as qualitative and quantitative definitions of EED. Biomarkers were organized into five EED domains, and the number of studies that support or do not support relationships among domains and between each domain with stunting were summarized.There was little evidence to support the pathway from intestinal permeability to microbial translocation and from microbial translocation to stunting, but stronger support existed for the link between intestinal inflammation and systemic inflammation and for intestinal inflammation and stunting. There was conflicting evidence for the pathways from intestinal damage to intestinal permeability and intestinal damage to stunting.These results suggest that certain EED biomarkers may require reconsideration, particularly those most difficult to measure, such as microbial translocation and intestinal permeability. We discuss several issues with currently used biomarkers and recommend further analysis of pathogen-induced changes to the intestinal microbiota as a pathway leading to stunting. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 12 1 e0006205 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Kaitlyn M Harper Maxine Mutasa Andrew J Prendergast Jean Humphrey Amee R Manges Environmental enteric dysfunction pathways and child stunting: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Environmental enteric dysfunction (EED) is commonly defined as an acquired subclinical disorder of the small intestine, characterized by villous atrophy and crypt hyperplasia. EED has been proposed to underlie stunted growth among children in developing countries. A collection of biomarkers, organized into distinct domains, has been used to measure different aspects of EED. Here, we examine whether these hypothesized relationships, among EED domains and between each domain and stunting, are supported by data from recent studies.A systematic literature search was conducted using PubMed, MEDLINE, EMBASE, Web of Science, and CINAHL between January 1, 2010 and April 20, 2017. Information on study objective, design, population, location, biomarkers, and results were recorded, as well as qualitative and quantitative definitions of EED. Biomarkers were organized into five EED domains, and the number of studies that support or do not support relationships among domains and between each domain with stunting were summarized.There was little evidence to support the pathway from intestinal permeability to microbial translocation and from microbial translocation to stunting, but stronger support existed for the link between intestinal inflammation and systemic inflammation and for intestinal inflammation and stunting. There was conflicting evidence for the pathways from intestinal damage to intestinal permeability and intestinal damage to stunting.These results suggest that certain EED biomarkers may require reconsideration, particularly those most difficult to measure, such as microbial translocation and intestinal permeability. We discuss several issues with currently used biomarkers and recommend further analysis of pathogen-induced changes to the intestinal microbiota as a pathway leading to stunting. |
format |
Article in Journal/Newspaper |
author |
Kaitlyn M Harper Maxine Mutasa Andrew J Prendergast Jean Humphrey Amee R Manges |
author_facet |
Kaitlyn M Harper Maxine Mutasa Andrew J Prendergast Jean Humphrey Amee R Manges |
author_sort |
Kaitlyn M Harper |
title |
Environmental enteric dysfunction pathways and child stunting: A systematic review. |
title_short |
Environmental enteric dysfunction pathways and child stunting: A systematic review. |
title_full |
Environmental enteric dysfunction pathways and child stunting: A systematic review. |
title_fullStr |
Environmental enteric dysfunction pathways and child stunting: A systematic review. |
title_full_unstemmed |
Environmental enteric dysfunction pathways and child stunting: A systematic review. |
title_sort |
environmental enteric dysfunction pathways and child stunting: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2018 |
url |
https://doi.org/10.1371/journal.pntd.0006205 https://doaj.org/article/7976463db31c4482ba83497860bbd2fe |
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Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 12, Iss 1, p e0006205 (2018) |
op_relation |
http://europepmc.org/articles/PMC5792022?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0006205 https://doaj.org/article/7976463db31c4482ba83497860bbd2fe |
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https://doi.org/10.1371/journal.pntd.0006205 |
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PLOS Neglected Tropical Diseases |
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12 |
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1 |
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e0006205 |
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