Course of infection and histopathological lesions in mice infected with seventeen Trypanosoma cruzi strains isolated from chronic patients
Mice were infected with blood forms of 17 Trypanosoma cruzi strains recently isolated from chronic patients, which were dassified as of low, medium or high virulence on grounds of the prepatent period, parasitemia and mortality at the acute phase. A total of 212 mice were studied after 3, 6, 9 and 1...
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Sociedade Brasileira de Medicina Tropical (SBMT)
1983
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ftdoajarticles:oai:doaj.org/article:7961e367177e431a9413a94374820436 2023-05-15T15:18:08+02:00 Course of infection and histopathological lesions in mice infected with seventeen Trypanosoma cruzi strains isolated from chronic patients B R Schlemper Jr C M Ávila J R Coura Z Brener 1983-03-01T00:00:00Z https://doaj.org/article/7961e367177e431a9413a94374820436 EN ES PT eng spa por Sociedade Brasileira de Medicina Tropical (SBMT) http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821983000100004 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/7961e367177e431a9413a94374820436 Revista da Sociedade Brasileira de Medicina Tropical, Vol 16, Iss 1, Pp 23-30 (1983) Trypanosoma cruzi Cepas Histopatologia Camundongo Strains Histopathology Mouse Arctic medicine. Tropical medicine RC955-962 article 1983 ftdoajarticles 2023-01-08T01:26:20Z Mice were infected with blood forms of 17 Trypanosoma cruzi strains recently isolated from chronic patients, which were dassified as of low, medium or high virulence on grounds of the prepatent period, parasitemia and mortality at the acute phase. A total of 212 mice were studied after 3, 6, 9 and 12 months of infection. In the chronic phase, intracellular parasites were detected in 11.0%,27.9%and 54.0,% of mice inoculated, respectively, with the low, medium and high virulent strains (r= 0.98, p < 0.005). Heart fibrosis was also related to virulence, affecting 5.7%, 11.6%and30.8% (r = 0.98, p < 0.001) of the mice inoculated with the above strains; a similar relationship was observed between intensity and frequency of the heart inflammatory reaction and the severity of infection at its early stage. Necrotizing arteritis was detected in 12.2% of the inoculated animals and this lesion was related to the infection duration rather than to strain characteristics. Inflammatory lesions and tissue parasitism were stable within the period of observation, whereas fibrosis was Progressive. The findings suggest that mice may reproduce heart lesions resembling human pathology and that organ damage apparently depends on the parasite virulence. Camundongos foram inoculados com formas sangüíneas de 17 cepas de T. cruzi recentemente isoladas de pacientes chagásicos crônicos e que foram classificadas como de alta, média e baixa virulência através da determinação do período pré-patente, parasitemia e mortalidade na fase aguda da infecção. Cerca de 212 animais inoculados com as diferentes cepas foram estudados após 3,6,9 e 12 meses de in fecção. Na fase crônica da infecção parasitas intracelulares foram observados em 11.0%, 27.0% e 54.0% dos camundongos inoculados respectivamente com as cepas de baixa, médiaealta virulência (r = 0.99, p < 0.001). A fibrose cardíaca também esteve relacionada à virulência sendo encontrada em 5.7%, 11.6% e 30.8% das mesmas cepas (r = 0.98, p < u.005); relação similar foi encontrada entre a ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Alta Aguda ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
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ftdoajarticles |
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English Spanish Portuguese |
topic |
Trypanosoma cruzi Cepas Histopatologia Camundongo Strains Histopathology Mouse Arctic medicine. Tropical medicine RC955-962 |
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Trypanosoma cruzi Cepas Histopatologia Camundongo Strains Histopathology Mouse Arctic medicine. Tropical medicine RC955-962 B R Schlemper Jr C M Ávila J R Coura Z Brener Course of infection and histopathological lesions in mice infected with seventeen Trypanosoma cruzi strains isolated from chronic patients |
topic_facet |
Trypanosoma cruzi Cepas Histopatologia Camundongo Strains Histopathology Mouse Arctic medicine. Tropical medicine RC955-962 |
description |
Mice were infected with blood forms of 17 Trypanosoma cruzi strains recently isolated from chronic patients, which were dassified as of low, medium or high virulence on grounds of the prepatent period, parasitemia and mortality at the acute phase. A total of 212 mice were studied after 3, 6, 9 and 12 months of infection. In the chronic phase, intracellular parasites were detected in 11.0%,27.9%and 54.0,% of mice inoculated, respectively, with the low, medium and high virulent strains (r= 0.98, p < 0.005). Heart fibrosis was also related to virulence, affecting 5.7%, 11.6%and30.8% (r = 0.98, p < 0.001) of the mice inoculated with the above strains; a similar relationship was observed between intensity and frequency of the heart inflammatory reaction and the severity of infection at its early stage. Necrotizing arteritis was detected in 12.2% of the inoculated animals and this lesion was related to the infection duration rather than to strain characteristics. Inflammatory lesions and tissue parasitism were stable within the period of observation, whereas fibrosis was Progressive. The findings suggest that mice may reproduce heart lesions resembling human pathology and that organ damage apparently depends on the parasite virulence. Camundongos foram inoculados com formas sangüíneas de 17 cepas de T. cruzi recentemente isoladas de pacientes chagásicos crônicos e que foram classificadas como de alta, média e baixa virulência através da determinação do período pré-patente, parasitemia e mortalidade na fase aguda da infecção. Cerca de 212 animais inoculados com as diferentes cepas foram estudados após 3,6,9 e 12 meses de in fecção. Na fase crônica da infecção parasitas intracelulares foram observados em 11.0%, 27.0% e 54.0% dos camundongos inoculados respectivamente com as cepas de baixa, médiaealta virulência (r = 0.99, p < 0.001). A fibrose cardíaca também esteve relacionada à virulência sendo encontrada em 5.7%, 11.6% e 30.8% das mesmas cepas (r = 0.98, p < u.005); relação similar foi encontrada entre a ... |
format |
Article in Journal/Newspaper |
author |
B R Schlemper Jr C M Ávila J R Coura Z Brener |
author_facet |
B R Schlemper Jr C M Ávila J R Coura Z Brener |
author_sort |
B R Schlemper Jr |
title |
Course of infection and histopathological lesions in mice infected with seventeen Trypanosoma cruzi strains isolated from chronic patients |
title_short |
Course of infection and histopathological lesions in mice infected with seventeen Trypanosoma cruzi strains isolated from chronic patients |
title_full |
Course of infection and histopathological lesions in mice infected with seventeen Trypanosoma cruzi strains isolated from chronic patients |
title_fullStr |
Course of infection and histopathological lesions in mice infected with seventeen Trypanosoma cruzi strains isolated from chronic patients |
title_full_unstemmed |
Course of infection and histopathological lesions in mice infected with seventeen Trypanosoma cruzi strains isolated from chronic patients |
title_sort |
course of infection and histopathological lesions in mice infected with seventeen trypanosoma cruzi strains isolated from chronic patients |
publisher |
Sociedade Brasileira de Medicina Tropical (SBMT) |
publishDate |
1983 |
url |
https://doaj.org/article/7961e367177e431a9413a94374820436 |
long_lat |
ENVELOPE(-26.750,-26.750,-76.150,-76.150) |
geographic |
Arctic Alta Aguda |
geographic_facet |
Arctic Alta Aguda |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Revista da Sociedade Brasileira de Medicina Tropical, Vol 16, Iss 1, Pp 23-30 (1983) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86821983000100004 https://doaj.org/toc/0037-8682 https://doaj.org/toc/1678-9849 0037-8682 1678-9849 https://doaj.org/article/7961e367177e431a9413a94374820436 |
_version_ |
1766348361831546880 |