Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge.
Intestinal helminth infection can impair host resistance to co-infection with enteric bacterial pathogens. However, it is not known whether helminth drug-clearance can restore host resistance to bacterial infection. Using a mouse helminth-Salmonella co-infection system, we show that anthelmintic tre...
Published in: | PLOS Neglected Tropical Diseases |
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Online Access: | https://doi.org/10.1371/journal.pntd.0009052 https://doaj.org/article/792b9c9ae60d47849dab72b19f7dd5ba |
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ftdoajarticles:oai:doaj.org/article:792b9c9ae60d47849dab72b19f7dd5ba 2023-05-15T15:05:37+02:00 Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge. Tara P Brosschot Katherine M Lawrence Brandon E Moeller Mia H E Kennedy Rachael D FitzPatrick Courtney M Gauthier Dongju Shin Dominique M Gatti Kate M E Conway Lisa A Reynolds 2021-01-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009052 https://doaj.org/article/792b9c9ae60d47849dab72b19f7dd5ba EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009052 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009052 https://doaj.org/article/792b9c9ae60d47849dab72b19f7dd5ba PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0009052 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009052 2022-12-31T11:51:04Z Intestinal helminth infection can impair host resistance to co-infection with enteric bacterial pathogens. However, it is not known whether helminth drug-clearance can restore host resistance to bacterial infection. Using a mouse helminth-Salmonella co-infection system, we show that anthelmintic treatment prior to Salmonella challenge is sufficient to restore host resistance to Salmonella. The presence of the small intestine-dwelling helminth Heligmosomoides polygyrus at the point of Salmonella infection supports the initial establishment of Salmonella in the small intestinal lumen. Interestingly, if helminth drug-clearance is delayed until Salmonella has already established in the small intestinal lumen, anthelmintic treatment does not result in complete clearance of Salmonella. This suggests that while the presence of helminths supports initial Salmonella colonization, helminths are dispensable for Salmonella persistence in the host small intestine. These data contribute to the mechanistic understanding of how an ongoing or prior helminth infection can affect pathogenic bacterial colonization and persistence in the mammalian intestine. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 15 1 e0009052 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tara P Brosschot Katherine M Lawrence Brandon E Moeller Mia H E Kennedy Rachael D FitzPatrick Courtney M Gauthier Dongju Shin Dominique M Gatti Kate M E Conway Lisa A Reynolds Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Intestinal helminth infection can impair host resistance to co-infection with enteric bacterial pathogens. However, it is not known whether helminth drug-clearance can restore host resistance to bacterial infection. Using a mouse helminth-Salmonella co-infection system, we show that anthelmintic treatment prior to Salmonella challenge is sufficient to restore host resistance to Salmonella. The presence of the small intestine-dwelling helminth Heligmosomoides polygyrus at the point of Salmonella infection supports the initial establishment of Salmonella in the small intestinal lumen. Interestingly, if helminth drug-clearance is delayed until Salmonella has already established in the small intestinal lumen, anthelmintic treatment does not result in complete clearance of Salmonella. This suggests that while the presence of helminths supports initial Salmonella colonization, helminths are dispensable for Salmonella persistence in the host small intestine. These data contribute to the mechanistic understanding of how an ongoing or prior helminth infection can affect pathogenic bacterial colonization and persistence in the mammalian intestine. |
format |
Article in Journal/Newspaper |
author |
Tara P Brosschot Katherine M Lawrence Brandon E Moeller Mia H E Kennedy Rachael D FitzPatrick Courtney M Gauthier Dongju Shin Dominique M Gatti Kate M E Conway Lisa A Reynolds |
author_facet |
Tara P Brosschot Katherine M Lawrence Brandon E Moeller Mia H E Kennedy Rachael D FitzPatrick Courtney M Gauthier Dongju Shin Dominique M Gatti Kate M E Conway Lisa A Reynolds |
author_sort |
Tara P Brosschot |
title |
Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge. |
title_short |
Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge. |
title_full |
Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge. |
title_fullStr |
Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge. |
title_full_unstemmed |
Impaired host resistance to Salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge. |
title_sort |
impaired host resistance to salmonella during helminth co-infection is restored by anthelmintic treatment prior to bacterial challenge. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009052 https://doaj.org/article/792b9c9ae60d47849dab72b19f7dd5ba |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 1, p e0009052 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009052 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009052 https://doaj.org/article/792b9c9ae60d47849dab72b19f7dd5ba |
op_doi |
https://doi.org/10.1371/journal.pntd.0009052 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
15 |
container_issue |
1 |
container_start_page |
e0009052 |
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1766337282632056832 |