Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole.
The onset of anthelmintic treatment of neurocysticercosis (NCC) provokes an acute immune response of the host, which in human cases is associated with exacerbation of neurological symptoms. This inflammation can occur at the first days of therapy. So, changes in the brain cysts appearance may be det...
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ftdoajarticles:oai:doaj.org/article:790ce88b112a45eda242c81b1df9d656 2023-05-15T15:15:55+02:00 Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole. Carla Cangalaya Javier A Bustos Juan Calcina Ana Vargas-Calla Javier Mamani Diego Suarez Gianfranco Arroyo Armando E Gonzalez Juan Chacaltana Cristina Guerra-Giraldez Siddhartha Mahanty Theodore E Nash Héctor H García Cysticercosis Working Group in Peru 2017-06-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0005624 https://doaj.org/article/790ce88b112a45eda242c81b1df9d656 EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5470720?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005624 https://doaj.org/article/790ce88b112a45eda242c81b1df9d656 PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005624 (2017) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2017 ftdoajarticles https://doi.org/10.1371/journal.pntd.0005624 2022-12-31T02:59:57Z The onset of anthelmintic treatment of neurocysticercosis (NCC) provokes an acute immune response of the host, which in human cases is associated with exacerbation of neurological symptoms. This inflammation can occur at the first days of therapy. So, changes in the brain cysts appearance may be detected by medical imaging. We evaluated radiological changes in the appearance of brain cysts (enhancement and size) on days two and five after the onset of antiparasitic treatment using naturally infected pigs as a model for human NCC.Contrast T1-weighted magnetic resonance imaging with gadolinium was performed before and after antiparasitic treatment. Eight NCC-infected pigs were treated with praziquantel plus albendazole and euthanized two (n = 4) and five (n = 4) days after treatment; another group of four infected pigs served as untreated controls. For each lesion, gadolinium enhancement intensity (GEI) and cyst volume were measured at baseline and after antiparasitic treatment. Volume and GEI quantification ratios (post/pre-treatment measures) were used to appraise the effect of treatment. Cysts from untreated pigs showed little variations between their basal and post treatment measures. At days 2 and 5 there were significant increases in GEI ratio compared with the untreated group (1.32 and 1.47 vs 1.01, p = 0.021 and p = 0.021). Cyst volume ratios were significantly lower at days 2 and 5 compared with the untreated group (0.60 and 0.22 vs 0.95, p = 0.04 and p = 0.02). Cysts with lower cyst volume ratios showed more marked post-treatment inflammation, loss of vesicular fluid and cyst wall wrinkling.A significant and drastic reduction of cyst size and increased pericystic enhancement occur in the initial days after antiparasitic treatment as an effect of acute perilesional immune response. These significant changes showed that early anthelmintic efficacy (day two) can be detected using magnetic resonance imaging. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 11 6 e0005624 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Carla Cangalaya Javier A Bustos Juan Calcina Ana Vargas-Calla Javier Mamani Diego Suarez Gianfranco Arroyo Armando E Gonzalez Juan Chacaltana Cristina Guerra-Giraldez Siddhartha Mahanty Theodore E Nash Héctor H García Cysticercosis Working Group in Peru Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
The onset of anthelmintic treatment of neurocysticercosis (NCC) provokes an acute immune response of the host, which in human cases is associated with exacerbation of neurological symptoms. This inflammation can occur at the first days of therapy. So, changes in the brain cysts appearance may be detected by medical imaging. We evaluated radiological changes in the appearance of brain cysts (enhancement and size) on days two and five after the onset of antiparasitic treatment using naturally infected pigs as a model for human NCC.Contrast T1-weighted magnetic resonance imaging with gadolinium was performed before and after antiparasitic treatment. Eight NCC-infected pigs were treated with praziquantel plus albendazole and euthanized two (n = 4) and five (n = 4) days after treatment; another group of four infected pigs served as untreated controls. For each lesion, gadolinium enhancement intensity (GEI) and cyst volume were measured at baseline and after antiparasitic treatment. Volume and GEI quantification ratios (post/pre-treatment measures) were used to appraise the effect of treatment. Cysts from untreated pigs showed little variations between their basal and post treatment measures. At days 2 and 5 there were significant increases in GEI ratio compared with the untreated group (1.32 and 1.47 vs 1.01, p = 0.021 and p = 0.021). Cyst volume ratios were significantly lower at days 2 and 5 compared with the untreated group (0.60 and 0.22 vs 0.95, p = 0.04 and p = 0.02). Cysts with lower cyst volume ratios showed more marked post-treatment inflammation, loss of vesicular fluid and cyst wall wrinkling.A significant and drastic reduction of cyst size and increased pericystic enhancement occur in the initial days after antiparasitic treatment as an effect of acute perilesional immune response. These significant changes showed that early anthelmintic efficacy (day two) can be detected using magnetic resonance imaging. |
format |
Article in Journal/Newspaper |
author |
Carla Cangalaya Javier A Bustos Juan Calcina Ana Vargas-Calla Javier Mamani Diego Suarez Gianfranco Arroyo Armando E Gonzalez Juan Chacaltana Cristina Guerra-Giraldez Siddhartha Mahanty Theodore E Nash Héctor H García Cysticercosis Working Group in Peru |
author_facet |
Carla Cangalaya Javier A Bustos Juan Calcina Ana Vargas-Calla Javier Mamani Diego Suarez Gianfranco Arroyo Armando E Gonzalez Juan Chacaltana Cristina Guerra-Giraldez Siddhartha Mahanty Theodore E Nash Héctor H García Cysticercosis Working Group in Peru |
author_sort |
Carla Cangalaya |
title |
Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole. |
title_short |
Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole. |
title_full |
Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole. |
title_fullStr |
Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole. |
title_full_unstemmed |
Radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole. |
title_sort |
radiological evolution of porcine neurocysticercosis after combined antiparasitic treatment with praziquantel and albendazole. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2017 |
url |
https://doi.org/10.1371/journal.pntd.0005624 https://doaj.org/article/790ce88b112a45eda242c81b1df9d656 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 11, Iss 6, p e0005624 (2017) |
op_relation |
http://europepmc.org/articles/PMC5470720?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0005624 https://doaj.org/article/790ce88b112a45eda242c81b1df9d656 |
op_doi |
https://doi.org/10.1371/journal.pntd.0005624 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
11 |
container_issue |
6 |
container_start_page |
e0005624 |
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1766346240951320576 |