Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy
The aim of this paper was to evaluate the immune reconstitution of HIV-1 patients subjected to highly active antiretroviral therapy (HAART) for two years or more according to CD45RA and CD45RO cell count; determination of IL-2, IFN-gamma, IL-4, IL-10 and TNF-alpha serum levels; CD4+ T and CD8+ T lym...
Published in: | Journal of Venomous Animals and Toxins including Tropical Diseases |
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ftdoajarticles:oai:doaj.org/article:79060125eaf4492c9ec9606b0fdedefc 2023-05-15T15:19:14+02:00 Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy R. A. M. B. Almeida L. R. Souza S. A. Calvi M. R. V. Ikoma V. A. Silva P. R. Curi D. A. Meira 2006-01-01T00:00:00Z https://doi.org/10.1590/S1678-91992006000100008 https://doaj.org/article/79060125eaf4492c9ec9606b0fdedefc EN eng SciELO http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100008 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000100008 1678-9199 https://doaj.org/article/79060125eaf4492c9ec9606b0fdedefc Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 1, Pp 91-109 (2006) HIV immune reconstitution antiretroviral HAART cytokines CD45RA CD45RO Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 article 2006 ftdoajarticles https://doi.org/10.1590/S1678-91992006000100008 2022-12-30T22:05:40Z The aim of this paper was to evaluate the immune reconstitution of HIV-1 patients subjected to highly active antiretroviral therapy (HAART) for two years or more according to CD45RA and CD45RO cell count; determination of IL-2, IFN-gamma, IL-4, IL-10 and TNF-alpha serum levels; CD4+ T and CD8+ T lymphocyte count; and plasma viral load (VL) determination. For this purpose, a cross sectional study was carried out in the Tropical Diseases Area, Botucatu School of Medicine, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil. Between June 2001 and April 2002, 37 HIV-1 infected patients were evaluated, 13 with treatment indication but untreated (G1), 9 subjected to HAART for 5-7 months (G2), and 15 treated for two years or more (G3); both treated groups used medication regularly and without failure. Forty-nine normal individuals were studied as controls (GC-1 and GC-2). There was a tendency (p<0.10) for the predominance of two nucleoside reverse transcriptase inhibitors (NRTI) associated with one non-nucleoside reverse transcriptase inhibitor (NNRTI) regimen in G2; and two NRTI associated with a protease inhibitor (PI) in G3. Statistical differences between groups were seen for CD45RA (G1<[G3=GC-2]; p<0.05) and CD45RO (G1<GC-2<G3; p<0.01) cells, and CD4+ T lymphocyte count (G1<G3; G2-intermediate; p<0.05), VL determination (G1>[G2=G3]; p<0.001), TNF-alpha serum determination ([G1>G3; G2=intermediate]>GC-1; p<0.001), IL-2 (G1<[G2=G3=GC-1]; p<0.01), IFN-gamma ([G1=GC-1]<[GC-2=G3]; p<0.001), IL-4 and IL-10 ([G1=G2=G3]>GC-1; p<0.001), serum cytokine profiles, with a higher proportion of subtype 2 in G1 and mature subtype 0 in G2 and G3 (p<0.005). There was no statistical difference for CD8+ T lymphocyte counts (G1=G2=G3; p<0.50). Consistency was seen between positive correlations of profile 1 definer cytokines (IL-2 and IFN-gamma), CD45RA and CD45RO cells, and CD4+ T lymphocyte counts and between positive correlations of profile 2 definer cytokines ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Journal of Venomous Animals and Toxins including Tropical Diseases 12 1 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
HIV immune reconstitution antiretroviral HAART cytokines CD45RA CD45RO Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
spellingShingle |
HIV immune reconstitution antiretroviral HAART cytokines CD45RA CD45RO Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 R. A. M. B. Almeida L. R. Souza S. A. Calvi M. R. V. Ikoma V. A. Silva P. R. Curi D. A. Meira Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy |
topic_facet |
HIV immune reconstitution antiretroviral HAART cytokines CD45RA CD45RO Arctic medicine. Tropical medicine RC955-962 Toxicology. Poisons RA1190-1270 Zoology QL1-991 |
description |
The aim of this paper was to evaluate the immune reconstitution of HIV-1 patients subjected to highly active antiretroviral therapy (HAART) for two years or more according to CD45RA and CD45RO cell count; determination of IL-2, IFN-gamma, IL-4, IL-10 and TNF-alpha serum levels; CD4+ T and CD8+ T lymphocyte count; and plasma viral load (VL) determination. For this purpose, a cross sectional study was carried out in the Tropical Diseases Area, Botucatu School of Medicine, São Paulo State University, UNESP, Botucatu, São Paulo, Brazil. Between June 2001 and April 2002, 37 HIV-1 infected patients were evaluated, 13 with treatment indication but untreated (G1), 9 subjected to HAART for 5-7 months (G2), and 15 treated for two years or more (G3); both treated groups used medication regularly and without failure. Forty-nine normal individuals were studied as controls (GC-1 and GC-2). There was a tendency (p<0.10) for the predominance of two nucleoside reverse transcriptase inhibitors (NRTI) associated with one non-nucleoside reverse transcriptase inhibitor (NNRTI) regimen in G2; and two NRTI associated with a protease inhibitor (PI) in G3. Statistical differences between groups were seen for CD45RA (G1<[G3=GC-2]; p<0.05) and CD45RO (G1<GC-2<G3; p<0.01) cells, and CD4+ T lymphocyte count (G1<G3; G2-intermediate; p<0.05), VL determination (G1>[G2=G3]; p<0.001), TNF-alpha serum determination ([G1>G3; G2=intermediate]>GC-1; p<0.001), IL-2 (G1<[G2=G3=GC-1]; p<0.01), IFN-gamma ([G1=GC-1]<[GC-2=G3]; p<0.001), IL-4 and IL-10 ([G1=G2=G3]>GC-1; p<0.001), serum cytokine profiles, with a higher proportion of subtype 2 in G1 and mature subtype 0 in G2 and G3 (p<0.005). There was no statistical difference for CD8+ T lymphocyte counts (G1=G2=G3; p<0.50). Consistency was seen between positive correlations of profile 1 definer cytokines (IL-2 and IFN-gamma), CD45RA and CD45RO cells, and CD4+ T lymphocyte counts and between positive correlations of profile 2 definer cytokines ... |
format |
Article in Journal/Newspaper |
author |
R. A. M. B. Almeida L. R. Souza S. A. Calvi M. R. V. Ikoma V. A. Silva P. R. Curi D. A. Meira |
author_facet |
R. A. M. B. Almeida L. R. Souza S. A. Calvi M. R. V. Ikoma V. A. Silva P. R. Curi D. A. Meira |
author_sort |
R. A. M. B. Almeida |
title |
Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy |
title_short |
Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy |
title_full |
Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy |
title_fullStr |
Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy |
title_full_unstemmed |
Immune reconstitution in HIV-1 infected patients treated for two years with highly active antiretroviral therapy |
title_sort |
immune reconstitution in hiv-1 infected patients treated for two years with highly active antiretroviral therapy |
publisher |
SciELO |
publishDate |
2006 |
url |
https://doi.org/10.1590/S1678-91992006000100008 https://doaj.org/article/79060125eaf4492c9ec9606b0fdedefc |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
Journal of Venomous Animals and Toxins including Tropical Diseases, Vol 12, Iss 1, Pp 91-109 (2006) |
op_relation |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1678-91992006000100008 https://doaj.org/toc/1678-9199 doi:10.1590/S1678-91992006000100008 1678-9199 https://doaj.org/article/79060125eaf4492c9ec9606b0fdedefc |
op_doi |
https://doi.org/10.1590/S1678-91992006000100008 |
container_title |
Journal of Venomous Animals and Toxins including Tropical Diseases |
container_volume |
12 |
container_issue |
1 |
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1766349414934249472 |