Candidin: comparison of two antigens for cutaneous delayed hypersensitivity testing Candidina: antígeno para reação de hipersensibilidade de tipo tardio. Comparação de dois antígenos
A candidin, which is a suspension of killed yeast cells, is commonly used for intradermal tests of delayed hypersensitivity, to evaluate the immunological cellular competence of the patient, when the test is applied along with other similar tests. When working with a cellular antigen, the histopatho...
| Published in: | Revista do Instituto de Medicina Tropical de São Paulo |
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| Main Authors: | , , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Universidade de São Paulo (USP)
1996
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| Subjects: | |
| Online Access: | https://doi.org/10.1590/S0036-46651996000600002 https://doaj.org/article/78e780ff218240e68c26888f793f0d2f |
| Summary: | A candidin, which is a suspension of killed yeast cells, is commonly used for intradermal tests of delayed hypersensitivity, to evaluate the immunological cellular competence of the patient, when the test is applied along with other similar tests. When working with a cellular antigen, the histopathology of positive skin tests reveals a cellular infiltrate which not only presents a characteristic hypersensitivity reaction but also a neutrophilic abscess in the central part. This research presents the results of a comparison between the yeast cell suspension and the polysaccharide antigens, both obtained from the same strains of Candida albicans. The results obtained by skin tests in one hundred individuals were 61.0% with the polysaccharide antigen and 69.0% with the yeast cell suspension antigen. Concordant results concerning the two antigens were observed in 82.0% of the individuals. The discussion section presents an assumption to explain the differences of positivity obtained with the two antigens. We conclude that the polysaccharide antigen can be utilized in the intradermal test of delayed hypersensitivity to Candida albicans. Candidina, constituída de suspensão de células leveduriformes mortas, é comumente usada em provas intradérmicas de hipersensibilidade retardada, principalmente na avaliação da competência imunológica do paciente, quando usada conjuntamente com outras provas intradérmicas do mesmo tipo. Considerando-se o estudo histopatológico de reação positiva com este tipo de antígeno, é possível obter uma reação positiva não específica na leitura da prova intradérmica. Esta pesquisa apresenta os resultados obtidos a partir da comparação entre o antígeno de suspensão celular e o antígeno polissacarídico, ambos obtidos a partir das mesmas amostras de Candida albicans. As diferenças observadas no estudo histopatológico de reações positivas com antígeno polissacarídico e com antígeno de suspensão celular podem explicar as diferenças observadas nas porcentagens entre reações intradérmicas positivas com ... |
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