Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization
Amphiphilic copolymers are appealing materials because of their interesting architecture and tunable properties. In view of their application in the biomedical field, the preparation of these materials should avoid the use of toxic compounds as catalysts. Therefore, enzymatic catalysis is a suitable...
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ftdoajarticles:oai:doaj.org/article:78df9c1113d740a1beedde673e610fe5 2023-05-15T13:36:56+02:00 Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization Ahmed Abd El-Fattah Elizabeth Grillo Fernandes Federica Chiellini Emo Chiellini 2022-01-01T00:00:00Z https://doi.org/10.3390/ijms23031390 https://doaj.org/article/78df9c1113d740a1beedde673e610fe5 EN eng MDPI AG https://www.mdpi.com/1422-0067/23/3/1390 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms23031390 1422-0067 1661-6596 https://doaj.org/article/78df9c1113d740a1beedde673e610fe5 International Journal of Molecular Sciences, Vol 23, Iss 1390, p 1390 (2022) Candida antarctica lipase B enzyme ring-opening polymerization ε-caprolactone Pluronic morphology Biology (General) QH301-705.5 Chemistry QD1-999 article 2022 ftdoajarticles https://doi.org/10.3390/ijms23031390 2022-12-31T10:40:55Z Amphiphilic copolymers are appealing materials because of their interesting architecture and tunable properties. In view of their application in the biomedical field, the preparation of these materials should avoid the use of toxic compounds as catalysts. Therefore, enzymatic catalysis is a suitable alternative to common synthetic routes. Pentablock copolymers (CUC) were synthesized with high yields by ring-opening polymerization of ε-caprolactone (ε-CL) initiated by Pluronic (EPE) and catalyzed by Candida antarctica lipase B enzyme. The variables to study the structure–property relationship were EPEs’ molecular weight and molar ratios between ε-CL monomer and EPE macro-initiator (M/In). The obtained copolymers were chemically characterized, the molecular weight determined, and morphologies evaluated. The results suggest an interaction between the reaction time and M/In variables. There was a correlation between the differential scanning calorimetry data with those of X-ray diffraction (WAXD). The length of the central block of CUC copolymers may have an important role in the crystal formation. WAXD analyses indicated that a micro-phase separation takes place in all the prepared copolymers. Preliminary cytotoxicity experiments on the extracts of the polymer confirmed that these materials are nontoxic. Article in Journal/Newspaper Antarc* Antarctica Directory of Open Access Journals: DOAJ Articles International Journal of Molecular Sciences 23 3 1390 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Candida antarctica lipase B enzyme ring-opening polymerization ε-caprolactone Pluronic morphology Biology (General) QH301-705.5 Chemistry QD1-999 |
spellingShingle |
Candida antarctica lipase B enzyme ring-opening polymerization ε-caprolactone Pluronic morphology Biology (General) QH301-705.5 Chemistry QD1-999 Ahmed Abd El-Fattah Elizabeth Grillo Fernandes Federica Chiellini Emo Chiellini Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
topic_facet |
Candida antarctica lipase B enzyme ring-opening polymerization ε-caprolactone Pluronic morphology Biology (General) QH301-705.5 Chemistry QD1-999 |
description |
Amphiphilic copolymers are appealing materials because of their interesting architecture and tunable properties. In view of their application in the biomedical field, the preparation of these materials should avoid the use of toxic compounds as catalysts. Therefore, enzymatic catalysis is a suitable alternative to common synthetic routes. Pentablock copolymers (CUC) were synthesized with high yields by ring-opening polymerization of ε-caprolactone (ε-CL) initiated by Pluronic (EPE) and catalyzed by Candida antarctica lipase B enzyme. The variables to study the structure–property relationship were EPEs’ molecular weight and molar ratios between ε-CL monomer and EPE macro-initiator (M/In). The obtained copolymers were chemically characterized, the molecular weight determined, and morphologies evaluated. The results suggest an interaction between the reaction time and M/In variables. There was a correlation between the differential scanning calorimetry data with those of X-ray diffraction (WAXD). The length of the central block of CUC copolymers may have an important role in the crystal formation. WAXD analyses indicated that a micro-phase separation takes place in all the prepared copolymers. Preliminary cytotoxicity experiments on the extracts of the polymer confirmed that these materials are nontoxic. |
format |
Article in Journal/Newspaper |
author |
Ahmed Abd El-Fattah Elizabeth Grillo Fernandes Federica Chiellini Emo Chiellini |
author_facet |
Ahmed Abd El-Fattah Elizabeth Grillo Fernandes Federica Chiellini Emo Chiellini |
author_sort |
Ahmed Abd El-Fattah |
title |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_short |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_full |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_fullStr |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_full_unstemmed |
Amphiphilic Pentablock Copolymers Prepared from Pluronic and ε-Caprolactone by Enzymatic Ring Opening Polymerization |
title_sort |
amphiphilic pentablock copolymers prepared from pluronic and ε-caprolactone by enzymatic ring opening polymerization |
publisher |
MDPI AG |
publishDate |
2022 |
url |
https://doi.org/10.3390/ijms23031390 https://doaj.org/article/78df9c1113d740a1beedde673e610fe5 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_source |
International Journal of Molecular Sciences, Vol 23, Iss 1390, p 1390 (2022) |
op_relation |
https://www.mdpi.com/1422-0067/23/3/1390 https://doaj.org/toc/1661-6596 https://doaj.org/toc/1422-0067 doi:10.3390/ijms23031390 1422-0067 1661-6596 https://doaj.org/article/78df9c1113d740a1beedde673e610fe5 |
op_doi |
https://doi.org/10.3390/ijms23031390 |
container_title |
International Journal of Molecular Sciences |
container_volume |
23 |
container_issue |
3 |
container_start_page |
1390 |
_version_ |
1766085732831592448 |