Invasive breast cancer among Alaska Native women in Alaska

Female breast cancer is the most common cancer diagnosed among Alaska Native (AN) women. We examined characteristics of and trends for female breast cancer among AN women. We assessed descriptive statistics, incidence trends (1969–2014), and cause-specific survival for female breast cancers recorded...

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Bibliographic Details
Published in:International Journal of Circumpolar Health
Main Authors: Sarah H Nash, Garrett Zimpelman, Barbara Stillwater, Matthew Olnes, Ellen Provost
Format: Article in Journal/Newspaper
Language:English
Published: Taylor & Francis Group 2019
Subjects:
native american
cancer surveillance
breast cancer
tumor registry
seer
Arctic medicine. Tropical medicine
RC955-962
Arctic
Indian
Circumpolar Health
International Journal of Circumpolar Health
Alaska
Online Access:https://doi.org/10.1080/22423982.2019.1633190
https://doaj.org/article/78c21332f9b34557b9a80f3576a9a581
Description
Summary:Female breast cancer is the most common cancer diagnosed among Alaska Native (AN) women. We examined characteristics of and trends for female breast cancer among AN women. We assessed descriptive statistics, incidence trends (1969–2014), and cause-specific survival for female breast cancers recorded in the Alaska Native Tumor Registry. Results indicated that the majority of breast cancers among AN were diagnosed among women aged over 50 years, at local stage, and with Hormone receptor (HR)+/Human Epidermal Growth Factor (HER) 2− subtype. Five-year average incidence (95% CI) in the most recent time-period (2009–2014) was 145.0/100,000 (130.4, 159.5)); this was not statistically different from the previous time-period. Survival from breast cancer was high and varied by stage and cancer subtype. Hazard of death was greater among those diagnosed with regional/distant/unknown disease, relative to local disease (HR (95%CI): 4.65 (1.66, 12.98)), and higher among those with HER2−/HR− cancers, relative to those with HER2-/HR+ cancers (HR (95%CI): 6.59 (2.23, 19.49)). This study provides a comprehensive description of breast cancer among AN women, providing new and updated information on clinical and demographic factors, cancer incidence trends, regional variations and breast cancer survival. Abbreviations: AIAN: American Indian/Alaska Native; AN: Alaska Native; ANMC: Alaska Native Medical Center; ANTR: Alaska Native Tumor Registry; CI: Confidence Interval; HR: Hazard Ratio; ICD-O-3: International Classification of Diseases for Oncology – Third Edition; NHW – Non-Hispanic Whites; SEER: Surveillance, Epidemiology and End Results.

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