Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach.
BACKGROUND:The World Health Organization identified Uganda as one of the 10 highly endemic countries for schistosomiasis. Annual mass drug administration (MDA) with praziquantel has led to a decline in intensity of Schistosoma mansoni infections in several areas. However, as hotspots with high (re)i...
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ftdoajarticles:oai:doaj.org/article:78ac5d0269324e0b972a20c407a00a6a 2023-05-15T15:16:26+02:00 Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach. Suzan C M Trienekens Christina L Faust Keila Meginnis Lucy Pickering Olivia Ericsson Andrina Nankasi Arinaitwe Moses Edridah M Tukahebwa Poppy H L Lamberton 2020-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0008266 https://doaj.org/article/78ac5d0269324e0b972a20c407a00a6a EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0008266 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008266 https://doaj.org/article/78ac5d0269324e0b972a20c407a00a6a PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008266 (2020) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2020 ftdoajarticles https://doi.org/10.1371/journal.pntd.0008266 2022-12-31T06:00:48Z BACKGROUND:The World Health Organization identified Uganda as one of the 10 highly endemic countries for schistosomiasis. Annual mass drug administration (MDA) with praziquantel has led to a decline in intensity of Schistosoma mansoni infections in several areas. However, as hotspots with high (re)infection rates remain, additional research on risk factors and implementing interventions to complement MDA are required to further reduce disease burden in these settings. Through a mixed-methods study we aimed to gain deeper understanding of how gender may impact risk and reinfection in order to inform disease control programmes and ascertain if gender-specific interventions may be beneficial. METHODOLOGY/PRINCIPAL FINDINGS:In Bugoto, Mayuge District, Eastern Uganda we conducted ethnographic observations (n = 16) and examined epidemiology (n = 55) and parasite population genetics (n = 16) in school-aged children (SAC), alongside a community-wide household survey (n = 130). Water contact was frequent at home, school and in the community and was of domestic, personal care, recreational, religious or commercial nature. Qualitative analysis of type of activity, duration, frequency, level of submersion and water contact sites in children showed only few behavioural differences in water contact between genders. However, survey data revealed that adult women carried out the vast majority of household tasks involving water contact. Reinfection rates (96% overall) and genetic diversity were high in boys (pre-He = 0.66; post-He = 0.67) and girls (pre-He = 0.65; post-He = 0.67), but no differences in reinfection rates (p = 0.62) or genetic diversity by gender before (p = 0.54) or after (p = 0.97) treatment were found. CONCLUSIONS/SIGNIFICANCE:This mixed methods approach showed complementary findings. Frequent water exposure with few differences between boys and girls was mirrored by high reinfection rates and genetic diversity in both genders. Disease control programmes should consider the high reinfection rates among SAC in ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 14 5 e0008266 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Suzan C M Trienekens Christina L Faust Keila Meginnis Lucy Pickering Olivia Ericsson Andrina Nankasi Arinaitwe Moses Edridah M Tukahebwa Poppy H L Lamberton Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
BACKGROUND:The World Health Organization identified Uganda as one of the 10 highly endemic countries for schistosomiasis. Annual mass drug administration (MDA) with praziquantel has led to a decline in intensity of Schistosoma mansoni infections in several areas. However, as hotspots with high (re)infection rates remain, additional research on risk factors and implementing interventions to complement MDA are required to further reduce disease burden in these settings. Through a mixed-methods study we aimed to gain deeper understanding of how gender may impact risk and reinfection in order to inform disease control programmes and ascertain if gender-specific interventions may be beneficial. METHODOLOGY/PRINCIPAL FINDINGS:In Bugoto, Mayuge District, Eastern Uganda we conducted ethnographic observations (n = 16) and examined epidemiology (n = 55) and parasite population genetics (n = 16) in school-aged children (SAC), alongside a community-wide household survey (n = 130). Water contact was frequent at home, school and in the community and was of domestic, personal care, recreational, religious or commercial nature. Qualitative analysis of type of activity, duration, frequency, level of submersion and water contact sites in children showed only few behavioural differences in water contact between genders. However, survey data revealed that adult women carried out the vast majority of household tasks involving water contact. Reinfection rates (96% overall) and genetic diversity were high in boys (pre-He = 0.66; post-He = 0.67) and girls (pre-He = 0.65; post-He = 0.67), but no differences in reinfection rates (p = 0.62) or genetic diversity by gender before (p = 0.54) or after (p = 0.97) treatment were found. CONCLUSIONS/SIGNIFICANCE:This mixed methods approach showed complementary findings. Frequent water exposure with few differences between boys and girls was mirrored by high reinfection rates and genetic diversity in both genders. Disease control programmes should consider the high reinfection rates among SAC in ... |
format |
Article in Journal/Newspaper |
author |
Suzan C M Trienekens Christina L Faust Keila Meginnis Lucy Pickering Olivia Ericsson Andrina Nankasi Arinaitwe Moses Edridah M Tukahebwa Poppy H L Lamberton |
author_facet |
Suzan C M Trienekens Christina L Faust Keila Meginnis Lucy Pickering Olivia Ericsson Andrina Nankasi Arinaitwe Moses Edridah M Tukahebwa Poppy H L Lamberton |
author_sort |
Suzan C M Trienekens |
title |
Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach. |
title_short |
Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach. |
title_full |
Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach. |
title_fullStr |
Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach. |
title_full_unstemmed |
Impacts of host gender on Schistosoma mansoni risk in rural Uganda-A mixed-methods approach. |
title_sort |
impacts of host gender on schistosoma mansoni risk in rural uganda-a mixed-methods approach. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2020 |
url |
https://doi.org/10.1371/journal.pntd.0008266 https://doaj.org/article/78ac5d0269324e0b972a20c407a00a6a |
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Arctic |
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Arctic |
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Arctic |
genre_facet |
Arctic |
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PLoS Neglected Tropical Diseases, Vol 14, Iss 5, p e0008266 (2020) |
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https://doi.org/10.1371/journal.pntd.0008266 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0008266 https://doaj.org/article/78ac5d0269324e0b972a20c407a00a6a |
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https://doi.org/10.1371/journal.pntd.0008266 |
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PLOS Neglected Tropical Diseases |
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e0008266 |
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