Apoptosis of the fibrocytes type 1 in the spiral ligament and blood labyrinth barrier disturbance cause hearing impairment in murine cerebral malaria

• Published in: Malaria Journal
• Main Authors: Schmutzhard Joachim, Kositz Christian H, Glueckert Rudolf, Schmutzhard Erich, Schrott-Fischer Annelies, Lackner Peter
• Format: Article in Journal/Newspaper
• Language: English
• Published: BMC 2012
• Subjects: Murine cerebral malaria; Hearing impairment; Apoptosis; Spiral ligament fibrocytes; Blood labyrinth barrier; Arctic medicine. Tropical medicine; RC955-962; Infectious and parasitic diseases; RC109-216; Arctic; Labyrinth
• Online Access: https://doi.org/10.1186/1475-2875-11-30; https://doaj.org/article/787edcb3ac36461b84b68c1ca81efd47

Abstract Background Experimental murine malaria has been shown to result in significant hearing impairment. Microscopic evaluation of the temporal bones of these animals has revealed regular morphology of the cochlea duct. Furthermore, the known vascular pathologic changes being associated with mala...