Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients.
Background Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remain...
Published in: | PLOS Neglected Tropical Diseases |
---|---|
Main Authors: | , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Public Library of Science (PLoS)
2019
|
Subjects: | |
Online Access: | https://doi.org/10.1371/journal.pntd.0007312 https://doaj.org/article/787982d3bcb449cb8108e1142bede8e6 |
id |
ftdoajarticles:oai:doaj.org/article:787982d3bcb449cb8108e1142bede8e6 |
---|---|
record_format |
openpolar |
spelling |
ftdoajarticles:oai:doaj.org/article:787982d3bcb449cb8108e1142bede8e6 2023-05-15T15:08:34+02:00 Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients. Tushar Shaw Chaitanya Tellapragada Asha Kamath Vandana Kalwaje Eshwara Chiranjay Mukhopadhyay 2019-05-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0007312 https://doaj.org/article/787982d3bcb449cb8108e1142bede8e6 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0007312 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007312 https://doaj.org/article/787982d3bcb449cb8108e1142bede8e6 PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007312 (2019) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2019 ftdoajarticles https://doi.org/10.1371/journal.pntd.0007312 2022-12-31T05:52:39Z Background Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear. Methodology/principal findings Clinical data and B. pseudomallei isolates obtained from 199 culture-confirmed cases of melioidosis diagnosed during 2006-2016 in South India were used to elucidate the host and pathogen specific variable virulence determinants associated with clinical presentations and disease outcome. Further, we determined the temporal variations and the influence of ecological factors on B.pseudomallei Lipopolysaccharide (LPS) genotypes causing infections. Severe forms of the disease were observed amongst 169 (85%) patients. Renal dysfunction and infection due to B.pseudomallei harboring BimABm variant had significant associations with severe forms of the disease. Diabetes mellitus, septicemic melioidosis and infection due to LPSB genotype were independent risk factors for mortality. LPSB (74%) and LPSA (20.6%) were the prevalent genotypes causing infections. Both genotypes demonstrated temporal variations and had significant correlations with rainfall and humidity. Conclusion/significance Our study findings suggest that the pathogen specific virulence traits under the influence of ecological factors are the key drivers for geographical variations in the molecular epidemiology of melioidosis. Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 13 5 e0007312 |
institution |
Open Polar |
collection |
Directory of Open Access Journals: DOAJ Articles |
op_collection_id |
ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
spellingShingle |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Tushar Shaw Chaitanya Tellapragada Asha Kamath Vandana Kalwaje Eshwara Chiranjay Mukhopadhyay Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Background Melioidosis is gaining recognition as an emerging infectious disease with diverse clinical manifestations and high-case fatality rates worldwide. However, the molecular epidemiology of the disease outside the endemic regions such as northeast part of Thailand and northern Australia remains unclear. Methodology/principal findings Clinical data and B. pseudomallei isolates obtained from 199 culture-confirmed cases of melioidosis diagnosed during 2006-2016 in South India were used to elucidate the host and pathogen specific variable virulence determinants associated with clinical presentations and disease outcome. Further, we determined the temporal variations and the influence of ecological factors on B.pseudomallei Lipopolysaccharide (LPS) genotypes causing infections. Severe forms of the disease were observed amongst 169 (85%) patients. Renal dysfunction and infection due to B.pseudomallei harboring BimABm variant had significant associations with severe forms of the disease. Diabetes mellitus, septicemic melioidosis and infection due to LPSB genotype were independent risk factors for mortality. LPSB (74%) and LPSA (20.6%) were the prevalent genotypes causing infections. Both genotypes demonstrated temporal variations and had significant correlations with rainfall and humidity. Conclusion/significance Our study findings suggest that the pathogen specific virulence traits under the influence of ecological factors are the key drivers for geographical variations in the molecular epidemiology of melioidosis. |
format |
Article in Journal/Newspaper |
author |
Tushar Shaw Chaitanya Tellapragada Asha Kamath Vandana Kalwaje Eshwara Chiranjay Mukhopadhyay |
author_facet |
Tushar Shaw Chaitanya Tellapragada Asha Kamath Vandana Kalwaje Eshwara Chiranjay Mukhopadhyay |
author_sort |
Tushar Shaw |
title |
Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients. |
title_short |
Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients. |
title_full |
Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients. |
title_fullStr |
Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients. |
title_full_unstemmed |
Implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients. |
title_sort |
implications of environmental and pathogen-specific determinants on clinical presentations and disease outcome in melioidosis patients. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2019 |
url |
https://doi.org/10.1371/journal.pntd.0007312 https://doaj.org/article/787982d3bcb449cb8108e1142bede8e6 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 13, Iss 5, p e0007312 (2019) |
op_relation |
https://doi.org/10.1371/journal.pntd.0007312 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0007312 https://doaj.org/article/787982d3bcb449cb8108e1142bede8e6 |
op_doi |
https://doi.org/10.1371/journal.pntd.0007312 |
container_title |
PLOS Neglected Tropical Diseases |
container_volume |
13 |
container_issue |
5 |
container_start_page |
e0007312 |
_version_ |
1766339909386240000 |