Measuring the global burden of chikungunya and Zika viruses: A systematic review.
Throughout the last decade, chikungunya virus (CHIKV) and Zika virus (ZIKV) infections have spread globally, causing a spectrum of disease that ranges from self-limited febrile illness to permanent severe disability, congenital anomalies, and early death. Nevertheless, estimates of their aggregate h...
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ftdoajarticles:oai:doaj.org/article:785cfa9fca1640fb86491620dfdf3952 2023-05-15T15:16:41+02:00 Measuring the global burden of chikungunya and Zika viruses: A systematic review. Christopher J Puntasecca Charles H King Angelle Desiree LaBeaud 2021-03-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0009055 https://doaj.org/article/785cfa9fca1640fb86491620dfdf3952 EN eng Public Library of Science (PLoS) https://doi.org/10.1371/journal.pntd.0009055 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009055 https://doaj.org/article/785cfa9fca1640fb86491620dfdf3952 PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009055 (2021) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2021 ftdoajarticles https://doi.org/10.1371/journal.pntd.0009055 2022-12-31T13:53:10Z Throughout the last decade, chikungunya virus (CHIKV) and Zika virus (ZIKV) infections have spread globally, causing a spectrum of disease that ranges from self-limited febrile illness to permanent severe disability, congenital anomalies, and early death. Nevertheless, estimates of their aggregate health impact are absent from the literature and are currently omitted from the Global Burden of Disease (GBD) reports. We systematically reviewed published literature and surveillance records to evaluate the global burden caused by CHIKV and ZIKV between 2010 and 2019, to calculate estimates of their disability-adjusted life year (DALY) impact. Extracted data on acute, chronic, and perinatal outcomes were used to create annualized DALY estimates, following techniques outlined in the GBD framework. This study is registered with PROSPERO (CRD42020192502). Of 7,877 studies identified, 916 were screened in detail, and 21 were selected for inclusion. Available data indicate that CHIKV and ZIKV caused the average yearly loss of over 106,000 and 44,000 DALYs, respectively, between 2010 and 2019. Both viruses caused substantially more burden in the Americas than in any other World Health Organization (WHO) region. This unequal distribution is likely due to a combination of limited active surveillance reporting in other regions and the lack of immunity that left the previously unexposed populations of the Americas susceptible to severe outbreaks during the last decade. Long-term rheumatic sequelae provided the largest DALY component for CHIKV, whereas congenital Zika syndrome (CZS) contributed most significantly for ZIKV. Acute symptoms and early mortality accounted for relatively less of the overall burden. Suboptimal reporting and inconsistent diagnostics limit precision when determining arbovirus incidence and frequency of complications. Despite these limitations, it is clear from our assessment that CHIKV and ZIKV represent a significant cause of morbidity that is not included in current disease burden reports. These ... Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic Daly ENVELOPE(63.761,63.761,-67.513,-67.513) PLOS Neglected Tropical Diseases 15 3 e0009055 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
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English |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Christopher J Puntasecca Charles H King Angelle Desiree LaBeaud Measuring the global burden of chikungunya and Zika viruses: A systematic review. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Throughout the last decade, chikungunya virus (CHIKV) and Zika virus (ZIKV) infections have spread globally, causing a spectrum of disease that ranges from self-limited febrile illness to permanent severe disability, congenital anomalies, and early death. Nevertheless, estimates of their aggregate health impact are absent from the literature and are currently omitted from the Global Burden of Disease (GBD) reports. We systematically reviewed published literature and surveillance records to evaluate the global burden caused by CHIKV and ZIKV between 2010 and 2019, to calculate estimates of their disability-adjusted life year (DALY) impact. Extracted data on acute, chronic, and perinatal outcomes were used to create annualized DALY estimates, following techniques outlined in the GBD framework. This study is registered with PROSPERO (CRD42020192502). Of 7,877 studies identified, 916 were screened in detail, and 21 were selected for inclusion. Available data indicate that CHIKV and ZIKV caused the average yearly loss of over 106,000 and 44,000 DALYs, respectively, between 2010 and 2019. Both viruses caused substantially more burden in the Americas than in any other World Health Organization (WHO) region. This unequal distribution is likely due to a combination of limited active surveillance reporting in other regions and the lack of immunity that left the previously unexposed populations of the Americas susceptible to severe outbreaks during the last decade. Long-term rheumatic sequelae provided the largest DALY component for CHIKV, whereas congenital Zika syndrome (CZS) contributed most significantly for ZIKV. Acute symptoms and early mortality accounted for relatively less of the overall burden. Suboptimal reporting and inconsistent diagnostics limit precision when determining arbovirus incidence and frequency of complications. Despite these limitations, it is clear from our assessment that CHIKV and ZIKV represent a significant cause of morbidity that is not included in current disease burden reports. These ... |
format |
Article in Journal/Newspaper |
author |
Christopher J Puntasecca Charles H King Angelle Desiree LaBeaud |
author_facet |
Christopher J Puntasecca Charles H King Angelle Desiree LaBeaud |
author_sort |
Christopher J Puntasecca |
title |
Measuring the global burden of chikungunya and Zika viruses: A systematic review. |
title_short |
Measuring the global burden of chikungunya and Zika viruses: A systematic review. |
title_full |
Measuring the global burden of chikungunya and Zika viruses: A systematic review. |
title_fullStr |
Measuring the global burden of chikungunya and Zika viruses: A systematic review. |
title_full_unstemmed |
Measuring the global burden of chikungunya and Zika viruses: A systematic review. |
title_sort |
measuring the global burden of chikungunya and zika viruses: a systematic review. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2021 |
url |
https://doi.org/10.1371/journal.pntd.0009055 https://doaj.org/article/785cfa9fca1640fb86491620dfdf3952 |
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ENVELOPE(63.761,63.761,-67.513,-67.513) |
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Arctic Daly |
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Arctic Daly |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 15, Iss 3, p e0009055 (2021) |
op_relation |
https://doi.org/10.1371/journal.pntd.0009055 https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0009055 https://doaj.org/article/785cfa9fca1640fb86491620dfdf3952 |
op_doi |
https://doi.org/10.1371/journal.pntd.0009055 |
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PLOS Neglected Tropical Diseases |
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15 |
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