DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions.
Dengue virus (DENV) is a human pathogen and its etiology has been widely established. There are many interactions between DENV and human proteins that have been reported in literature. However, no publicly accessible resource for efficiently retrieving the information is yet available. In this study...
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ftdoajarticles:oai:doaj.org/article:785a2b1ad3424b91916cd61c83bfb53c 2023-05-15T15:07:36+02:00 DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions. Prashanthi Karyala Rahul Metri Christopher Bathula Syam K Yelamanchi Lipika Sahoo Selvam Arjunan Narayan P Sastri Nagasuma Chandra 2016-09-01T00:00:00Z https://doi.org/10.1371/journal.pntd.0004965 https://doaj.org/article/785a2b1ad3424b91916cd61c83bfb53c EN eng Public Library of Science (PLoS) http://europepmc.org/articles/PMC5019383?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004965 https://doaj.org/article/785a2b1ad3424b91916cd61c83bfb53c PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004965 (2016) Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 article 2016 ftdoajarticles https://doi.org/10.1371/journal.pntd.0004965 2022-12-31T02:11:25Z Dengue virus (DENV) is a human pathogen and its etiology has been widely established. There are many interactions between DENV and human proteins that have been reported in literature. However, no publicly accessible resource for efficiently retrieving the information is yet available. In this study, we mined all publicly available dengue-human interactions that have been reported in the literature into a database called DenHunt. We retrieved 682 direct interactions of human proteins with dengue viral components, 382 indirect interactions and 4120 differentially expressed human genes in dengue infected cell lines and patients. We have illustrated the importance of DenHunt by mapping the dengue-human interactions on to the host interactome and observed that the virus targets multiple host functional complexes of important cellular processes such as metabolism, immune system and signaling pathways suggesting a potential role of these interactions in viral pathogenesis. We also observed that 7 percent of the dengue virus interacting human proteins are also associated with other infectious and non-infectious diseases. Finally, the understanding that comes from such analyses could be used to design better strategies to counteract the diseases caused by dengue virus. The whole dataset has been catalogued in a searchable database, called DenHunt (http://proline.biochem.iisc.ernet.in/DenHunt/). Article in Journal/Newspaper Arctic Directory of Open Access Journals: DOAJ Articles Arctic PLOS Neglected Tropical Diseases 10 9 e0004965 |
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Directory of Open Access Journals: DOAJ Articles |
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ftdoajarticles |
language |
English |
topic |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
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Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 Prashanthi Karyala Rahul Metri Christopher Bathula Syam K Yelamanchi Lipika Sahoo Selvam Arjunan Narayan P Sastri Nagasuma Chandra DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions. |
topic_facet |
Arctic medicine. Tropical medicine RC955-962 Public aspects of medicine RA1-1270 |
description |
Dengue virus (DENV) is a human pathogen and its etiology has been widely established. There are many interactions between DENV and human proteins that have been reported in literature. However, no publicly accessible resource for efficiently retrieving the information is yet available. In this study, we mined all publicly available dengue-human interactions that have been reported in the literature into a database called DenHunt. We retrieved 682 direct interactions of human proteins with dengue viral components, 382 indirect interactions and 4120 differentially expressed human genes in dengue infected cell lines and patients. We have illustrated the importance of DenHunt by mapping the dengue-human interactions on to the host interactome and observed that the virus targets multiple host functional complexes of important cellular processes such as metabolism, immune system and signaling pathways suggesting a potential role of these interactions in viral pathogenesis. We also observed that 7 percent of the dengue virus interacting human proteins are also associated with other infectious and non-infectious diseases. Finally, the understanding that comes from such analyses could be used to design better strategies to counteract the diseases caused by dengue virus. The whole dataset has been catalogued in a searchable database, called DenHunt (http://proline.biochem.iisc.ernet.in/DenHunt/). |
format |
Article in Journal/Newspaper |
author |
Prashanthi Karyala Rahul Metri Christopher Bathula Syam K Yelamanchi Lipika Sahoo Selvam Arjunan Narayan P Sastri Nagasuma Chandra |
author_facet |
Prashanthi Karyala Rahul Metri Christopher Bathula Syam K Yelamanchi Lipika Sahoo Selvam Arjunan Narayan P Sastri Nagasuma Chandra |
author_sort |
Prashanthi Karyala |
title |
DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions. |
title_short |
DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions. |
title_full |
DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions. |
title_fullStr |
DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions. |
title_full_unstemmed |
DenHunt - A Comprehensive Database of the Intricate Network of Dengue-Human Interactions. |
title_sort |
denhunt - a comprehensive database of the intricate network of dengue-human interactions. |
publisher |
Public Library of Science (PLoS) |
publishDate |
2016 |
url |
https://doi.org/10.1371/journal.pntd.0004965 https://doaj.org/article/785a2b1ad3424b91916cd61c83bfb53c |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_source |
PLoS Neglected Tropical Diseases, Vol 10, Iss 9, p e0004965 (2016) |
op_relation |
http://europepmc.org/articles/PMC5019383?pdf=render https://doaj.org/toc/1935-2727 https://doaj.org/toc/1935-2735 1935-2727 1935-2735 doi:10.1371/journal.pntd.0004965 https://doaj.org/article/785a2b1ad3424b91916cd61c83bfb53c |
op_doi |
https://doi.org/10.1371/journal.pntd.0004965 |
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PLOS Neglected Tropical Diseases |
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10 |
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9 |
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e0004965 |
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